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Alzheimer’s Disease Theranostics discusses the latest information on recent theranostic avenues for both the diagnosis and treatment of Alzheimer’s patients. It presents the pros and cons of the probable mechanistic role of nanoparticles in crossing the blood-brain barrier and improving disease symptoms. Finally, it highlights the merits of existing maneuvers and suggests perspectives to aid in future developments. Despite the difficulty of drug delivery to the brain, there are some nanoparticulate platforms demonstrating promise in treating neurodegenerative disorders such as Alzheimer’s disease. Manifold theranostic maneuvers include antioxidants, natural bioactive compounds, gene therapy, and nanotechnological approaches, all of which are discussed in this important work.
- Examines various theranostic applications for the diagnosis and treatment of Alzheimer’s disease
- Features a comprehensive overview of nanoparticle therapeutics in the area and use of antioxidants
- Assesses the common challenges and lessons learned from blood-brain barrier challenges, viral vector approaches and mitochondria-targeted therapeutics
Neuroscientists, biomedical researchers and graduate students, medical students. Materials and biomaterials scientists/biomedical engineering researchers/students, nutrition professionals
Chapter 1: Introduction: Alzheimer’s Disease Pathology and Therapeutics
Chapter 1 focuses on an overview of Alzheimer’s pathology and current therapeutic strategies. It also highlights the shortcomings of existing therapeutic strategies.
Chapter 2: Early Diagnosis of Alzheimer’s Disease: Pros and Cons
The multitude of theranostic tools employed to diagnose the disease will be highlighted in this chapter.
Chapter 3: Antioxidants in Alzheimer’s Therapy
Chapter 3 highlights the wide range of antioxidants used in the treatment of Alzheimer’s and their associated bioavailability issues, where applicable.
Chapter 4: Natural Compounds in the Treatment of Alzheimer’s Disease
Although various natural compounds have been employed to treat Alzheimer’s, their success is limited by a few shortcomings. This chapter focuses on the pros and cons of compounds currently in use.
Chapter 5: Blood Brain Barrier
A wide range of strategies have been employed to overcome blood brain barrier challenges. A review of more recent findings will be highlighted in this chapter.
Chapter 6: Gene Therapy: The Cornerstone in the Development of Alzheimer’s Disease Therapeutics
More recently, researchers have employed gene therapy strategies to overcome neurodegeneration. This chapter highlights these strategies.
Chapter 7: Viral vector therapeutics against Alzheimer’s Disease
Extensively used viral vector therapeutics for treating Alzheimer’s will be highlighted in this chapter.
Chapter 8: Mitochondria-Targeted Nanoparticles: A Milestone or a Mirage in the Treatment of Alzheimer’s Disease
Mitochondria targeting has been of utmost important for nanotechnology researchers due to its potential to combat several diseases. They are highlighted as are shortcomings and future perspectives.
Chapter 9: Nanoparticles: The Double-Edged Swords
Despite the significant therapeutic efficacy of antioxidants, short systemic circulation impedes their success. This chapter focuses on nanoformulations that have been discovered to overcome these issues.
Chapter 10: Alzheimer Therapeutics: Pros and Cons
Although many therapeutics strategies have been employed since the discovery of the disease, there remain no appropriate therapeutics to overcome it. This chapter highlights current limitations and future perspectives
- No. of pages:
- © Academic Press 2019
- 24th January 2019
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Magisetty Obulesu is a research associate in University of Tsukuba, Tsukuba, Japan. He has 20 years of research and teaching experience. He is also an editorial board of nanotechnology journals including SciFed Nanotech Research Letters, SciFed Drug Delivery Research, Current Updates in Nanotechnology and Journal of Nanotechnology and Materials Science. His research areas include food science, pathology of neurodegenerative diseases such as Alzheimer’s disease, designing polymer-based biomaterials such as hydrogels, and development of metal chelators to overcome metal induced toxicity. He has researched Alzheimer’s disease and developed an aluminium-induced neurotoxicity rabbit model. Mr. Obulesu’s present research focuses on development of redox-active injectable hydrogels of polyion complex. He has written three books and edited two more; he is also the first and corresponding author for majority of his articles.
University of Tsukuba, Tsukuba, Japan
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