AID for Immunoglobulin Diversity - 1st Edition - ISBN: 9780123737069, 9780080545929

AID for Immunoglobulin Diversity, Volume 94

1st Edition

Editors: Frederick Alt
eBook ISBN: 9780080545929
Hardcover ISBN: 9780123737069
Imprint: Academic Press
Published Date: 5th June 2007
Page Count: 344
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Table of Contents

Discovery of Activation-Induced Cytidine Deaminase, the Engraver of Antibody Memory DNA Deamination in Immunity: Aid in the Context of Its Apobec Relatives The Role of Activation Induced Deaminase in Antibody Diversification and Chromosome Translocations Targeting of AID-mediated Sequence Diversification by cis-acting Determinants AID-initiated Purposeful Mutations in Immunoglobulin Genes Post-translational AID Regulation Beyond SHM and CSR: AID and Related Cytidine Deaminases in the Host Response to Viral Infection AID expression and tumorigenesis
Pathophysiology of B Cell Intrinsic Immunoglobulin Class Switch Recombination Deficiencies


Description

Advances in Immunology, a long established and highly respected serial, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists


Details

No. of pages:
344
Language:
English
Copyright:
© Academic Press 2007
Published:
Imprint:
Academic Press
eBook ISBN:
9780080545929
Hardcover ISBN:
9780123737069

Ratings and Reviews


About the Editors

Frederick Alt Editor

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA