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Aging - 2nd Edition - ISBN: 9780128186985, 9780128188118


2nd Edition

Oxidative Stress and Dietary Antioxidants

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Editors: Victor Preedy Vinood Patel
Paperback ISBN: 9780128186985
eBook ISBN: 9780128188118
Imprint: Academic Press
Published Date: 27th May 2020
Page Count: 398
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Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this.

Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients.

Key Features

  • Compares information related to mitochondrial oxidative stress in one disease to diet-related strategies in other unrelated diseases
  • Provides an understanding of cell signalling leading to new suggestions of preventative or therapeutic strategies
  • Includes a new section dedicated to animal models of aging


Researchers of aging, gerontologists, geriatricians, nutritionists and dieticians

Table of Contents


I. Oxidative stress and aging

1. Oxidative stress and mir-200c
Alessandra Magenta, Maria Cristina Florio, Marco D’Agostino, Sara Sileno

2. Caloric restriction, reactive oxygen species, and longevity
Miyuki Kobara, Hiroe Toba, Tetsuo Nakata

3. Cardiovascular disease in aging and the role of oxidative stress
Lucie Orliaguet, Vinood B. Patel, Victor R. Preedy, Fawaz Alzaid

4. Aging, oxidative stress, mitochondrial dysfunction, and the liver
Janice G. Lozada-Delgado, Carlos A. Torres-Ramos, Sylvette Ayala-Peña

5. Culprit effect of oxidative stress in the development of parkinson’s disease: a conundrum of senescence
Rahul Saxena, Gladys Rai

6. Linking bone cells, aging, and oxidative stress: osteoblasts, osteoclasts, osteocytes, and bone marrow cells
Juan A. Ardura, Luis Álvarez-Carrión, Arancha R. Gortázar, Verónica Alonso

7. Oxidative stress, senescence and mediterranean diet effects on osteoarthritis
Sergio Ammendola, Anna Scotto D’Abusco

8. Arthritis as a disease of aging and changes in antioxidant status
Rahul Saxena, Jyoti Batra

9. Oxidative stress and sarcopenia
Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale

10. Oxidative stress and hypertension in old age: the role of physical exercise
Clodoaldo Antônio De Sá, Vanessa Corralo, Francielle Garghetti Battiston, Maria Isabel Gonc¸ Alves Da Silva

11. Linking senescence, apoptosis, and oxidative stress in fertility
Mathias Abiodun Emokpae, Osaretin Godwin Igharo

12. Antioxidant capacity and menopausal symptoms
Gity Sotoudeh, Maryam Abshirini

II. Antioxidants and aging

13. Reference dietary requirements of antioxidant vitamins in the older adults
Mina Yamazaki Price, Victor R. Preedy

14. Oxidative stress and antioxidants in elderly women
Brunna Cristina Bremer Boaventura, Patricia Faria Di Pietro, Francieli Cembranel

15. Caffeine and its analogs, antioxidants, and applications
Beata Jasiewicz, Arleta Sierakowska

16. Coenzyme q10 as an antioxidant in the elderly
Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, Antonio Garcia-Rios, Javier Delgado-Lista, Pablo Pérez-Martinez, Antonio Camargo, Francisco Perez-Jimenez, Jose Lopez-Miranda

17. The role of coenzyme q10 in the protection of bone health during aging
José L. Quiles, José M. Romero-Márquez, Mariá D. Navarro-Hortal, Maurizio Battino, Alfonso Varela-López

18. Coenzyme q10 supplementation in aging
Guillermo López-Lluch, Plácido Navas

19. Crocus sativus l. (saffron) extract antioxidant potential and use in aging
Saeed Samarghandian, Tahereh Farkhondeh, Tayebeh Zeinali

20. Pharmacological profile of γ-oryzanol: its antioxidant mechanisms and its effects in age-related diseases
Wiramon Rungratanawanich, Giulia Abate, Daniela Uberti

21. Herbs including shell ginger, antioxidant profiles, aging, and longevity in okinawa, japan: a critical analysis of current concepts
Rolf Teschke, Tran Dang Xuan

22. Lycopene as an antioxidant in the prevention and treatment of postmenopausal osteoporosis
L.G. Rao, E.S. Mackinnon, A.V. Rao

23. Medicinal plants, antioxidant potential, and applications to aging
Waseem Hassan, Mehreen Zafar, Jean Paul Kamdem

24. Antioxidant and anti-inflammatory role of melatonin in alzheimer’s neurodegeneration
Sergio A. Rosales-Corral, Russel J. Reiter, Xiaoyan Liu

25. Murici (byrsonima crassifolia (l.) Kunth): antioxidant effects and application to aging
Mariana Séfora Bezerra Sousa Diego De Souza Buarque

26. Natural products in aging skin
Mahendran Sekar

27. Antioxidant properties and applications of ophiopogon japonicus root for age-related disease
Yumi Kitahiro, Makio Shibano

28. Passion fruit seed: its antioxidative extracts and potency in protection of skin aging
Nattaya Lourith, Mayuree Kanlayavattanakul

29. Phaseolus vulgaris l. As a functional food for aging protection
Eunice Santos, Guilhermina Marques, Teresa Lino-Neto

30. Quercetin and resveratrol, aging and kidney
Mina Hemmati, Maryam Moossavi

31. Rambutan fruits extract in aging skin
Mahendran Sekar

32. Resveratrol, aging, and fatigue
Luana Toniolo, Emiliana Giacomello

33. Resveratrol, sirt1, oxidative stress, and brain aging
Fiorella Sarubbo, Silvia Tejada, Susana Esteban, Manuel Jimenez-Garciá, David Moranta

34. Antioxidants, vegetarian diets, and age-related disease
Andrew C. Bulmer, Shailendra Anoopkumar-Dukie, Iris F.F. Benzie

35. Protective effect of vitamin d on oxidative stress in elderly people
Brunna Cristina Bremer Boaventura, Francieli Cembranel

36. Zinc, oxidative stress in the elderly, and implication for inflammation
Ananda S. Prasad, Bin Bao

37. Oxidative stress and the senescence acceleration in senescence-accelerated mouse p10 (samp10)
Takeshi Saito, Masaaki Kurasaki

38. Recommended resources on aging: oxidative stress and dietary antioxidants
Rajkumar Rajendram, Vinood B. Patel, Victor R. Preedy



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© Academic Press 2020
27th May 2020
Academic Press
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About the Editors

Victor Preedy

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Vinood Patel

Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London (Diabetes and Nutritional Sciences Division and the Department of Nutrition and Dietetics). He presently directs studies on molecular and metabolic pathways involved in organ disease, particularly related to subcellular organelles and cell death. He directs research into the role of nutrients, antioxidants, phytochemicals, minerals, toxins and macronutrients. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of disease and understanding oxidative stress. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized liver researcher and was involved in several NIH-funded biomedical grants. Dr Patel has edited more than 20 biomedical books in the area of nutrition, health and disease and has published over 150 articles In 2014, he was elected as a Fellow to the prestigious Royal Society of Chemistry for bridging the academic and intellectual gap between chemistry and biological function.

Affiliations and Expertise

Department of Biomedical Sciences, Faculty of Science and Technology University of Westminster, London, UK

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