Oxidative Stress and Dietary Antioxidants

2nd Edition - May 24, 2020

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  • Editors: Victor Preedy, Vinood Patel
  • Paperback ISBN: 9780128186985
  • eBook ISBN: 9780128188118

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Aging: Oxidative Stress and Dietary Antioxidants, Second Edition, bridges the trans-disciplinary divide and covers the science of oxidative stress in aging and the therapeutic use of natural antioxidants in the food matrix in a single volume. The second edition covers new trials and investigations used to determine the comprehensive properties of antioxidants, food items and extracts, as well as any adverse properties they may have. It has been updated to include new clinical human trials and a new section dedicated to animal models of aging. Throughtout the book the processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. This will aid in better research, treatment and outcome for patients.

Key Features

  • Compares information related to mitochondrial oxidative stress in one disease to diet-related strategies in other unrelated diseases
  • Provides an understanding of cell signalling leading to new suggestions of preventative or therapeutic strategies
  • Includes a new section dedicated to animal models of aging


Researchers of aging, gerontologists, geriatricians, nutritionists and dieticians

Table of Contents

  • Preface

    I. Oxidative stress and aging

    1. Oxidative stress and mir-200c
    Alessandra Magenta, Maria Cristina Florio, Marco D’Agostino, Sara Sileno

    2. Caloric restriction, reactive oxygen species, and longevity
    Miyuki Kobara, Hiroe Toba, Tetsuo Nakata

    3. Cardiovascular disease in aging and the role of oxidative stress
    Lucie Orliaguet, Vinood B. Patel, Victor R. Preedy, Fawaz Alzaid

    4. Aging, oxidative stress, mitochondrial dysfunction, and the liver
    Janice G. Lozada-Delgado, Carlos A. Torres-Ramos, Sylvette Ayala-Peña

    5. Culprit effect of oxidative stress in the development of parkinson’s disease: a conundrum of senescence
    Rahul Saxena, Gladys Rai

    6. Linking bone cells, aging, and oxidative stress: osteoblasts, osteoclasts, osteocytes, and bone marrow cells
    Juan A. Ardura, Luis Álvarez-Carrión, Arancha R. Gortázar, Verónica Alonso

    7. Oxidative stress, senescence and mediterranean diet effects on osteoarthritis
    Sergio Ammendola, Anna Scotto D’Abusco

    8. Arthritis as a disease of aging and changes in antioxidant status
    Rahul Saxena, Jyoti Batra

    9. Oxidative stress and sarcopenia
    Francesco Bellanti, Aurelio Lo Buglio, Gianluigi Vendemiale

    10. Oxidative stress and hypertension in old age: the role of physical exercise
    Clodoaldo Antônio De Sá, Vanessa Corralo, Francielle Garghetti Battiston, Maria Isabel Gonc¸ Alves Da Silva

    11. Linking senescence, apoptosis, and oxidative stress in fertility
    Mathias Abiodun Emokpae, Osaretin Godwin Igharo

    12. Antioxidant capacity and menopausal symptoms
    Gity Sotoudeh, Maryam Abshirini

    II. Antioxidants and aging

    13. Reference dietary requirements of antioxidant vitamins in the older adults
    Mina Yamazaki Price, Victor R. Preedy

    14. Oxidative stress and antioxidants in elderly women
    Brunna Cristina Bremer Boaventura, Patricia Faria Di Pietro, Francieli Cembranel

    15. Caffeine and its analogs, antioxidants, and applications
    Beata Jasiewicz, Arleta Sierakowska

    16. Coenzyme q10 as an antioxidant in the elderly
    Elena M. Yubero-Serrano, Francisco M. Gutierrez-Mariscal, Antonio Garcia-Rios, Javier Delgado-Lista, Pablo Pérez-Martinez, Antonio Camargo, Francisco Perez-Jimenez, Jose Lopez-Miranda

    17. The role of coenzyme q10 in the protection of bone health during aging
    José L. Quiles, José M. Romero-Márquez, Mariá D. Navarro-Hortal, Maurizio Battino, Alfonso Varela-López

    18. Coenzyme q10 supplementation in aging
    Guillermo López-Lluch, Plácido Navas

    19. Crocus sativus l. (saffron) extract antioxidant potential and use in aging
    Saeed Samarghandian, Tahereh Farkhondeh, Tayebeh Zeinali

    20. Pharmacological profile of γ-oryzanol: its antioxidant mechanisms and its effects in age-related diseases
    Wiramon Rungratanawanich, Giulia Abate, Daniela Uberti

    21. Herbs including shell ginger, antioxidant profiles, aging, and longevity in okinawa, japan: a critical analysis of current concepts
    Rolf Teschke, Tran Dang Xuan

    22. Lycopene as an antioxidant in the prevention and treatment of postmenopausal osteoporosis
    L.G. Rao, E.S. Mackinnon, A.V. Rao

    23. Medicinal plants, antioxidant potential, and applications to aging
    Waseem Hassan, Mehreen Zafar, Jean Paul Kamdem

    24. Antioxidant and anti-inflammatory role of melatonin in alzheimer’s neurodegeneration
    Sergio A. Rosales-Corral, Russel J. Reiter, Xiaoyan Liu

    25. Murici (byrsonima crassifolia (l.) Kunth): antioxidant effects and application to aging
    Mariana Séfora Bezerra Sousa Diego De Souza Buarque

    26. Natural products in aging skin
    Mahendran Sekar

    27. Antioxidant properties and applications of ophiopogon japonicus root for age-related disease
    Yumi Kitahiro, Makio Shibano

    28. Passion fruit seed: its antioxidative extracts and potency in protection of skin aging
    Nattaya Lourith, Mayuree Kanlayavattanakul

    29. Phaseolus vulgaris l. As a functional food for aging protection
    Eunice Santos, Guilhermina Marques, Teresa Lino-Neto

    30. Quercetin and resveratrol, aging and kidney
    Mina Hemmati, Maryam Moossavi

    31. Rambutan fruits extract in aging skin
    Mahendran Sekar

    32. Resveratrol, aging, and fatigue
    Luana Toniolo, Emiliana Giacomello

    33. Resveratrol, sirt1, oxidative stress, and brain aging
    Fiorella Sarubbo, Silvia Tejada, Susana Esteban, Manuel Jimenez-Garciá, David Moranta

    34. Antioxidants, vegetarian diets, and age-related disease
    Andrew C. Bulmer, Shailendra Anoopkumar-Dukie, Iris F.F. Benzie

    35. Protective effect of vitamin d on oxidative stress in elderly people
    Brunna Cristina Bremer Boaventura, Francieli Cembranel

    36. Zinc, oxidative stress in the elderly, and implication for inflammation
    Ananda S. Prasad, Bin Bao

    37. Oxidative stress and the senescence acceleration in senescence-accelerated mouse p10 (samp10)
    Takeshi Saito, Masaaki Kurasaki

    38. Recommended resources on aging: oxidative stress and dietary antioxidants
    Rajkumar Rajendram, Vinood B. Patel, Victor R. Preedy


Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: May 24, 2020
  • Imprint: Academic Press
  • Paperback ISBN: 9780128186985
  • eBook ISBN: 9780128188118

About the Editors

Victor Preedy

Dr. Preedy is a senior member of King's College London and Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy has longstanding academic interests in substance misuse especially in relation to health and well-being. In his career Professor Preedy was Reader at the Addictive Behaviour Centre at The University of Roehampton, and also Reader at the School of Pharmacy (now part of University College London; UCL). Professor Preedy is an extremely experienced book editor, having edited influential works including but not limited to The Handbook of Alcohol Related Pathology, The Neuropathology of Drug Addictions and Substance Misuse, The Handbook of Cannabis and Related Pathologies, The Neuroscience of Cocaine, and upcoming titles The Neuroscience of Alcohol, The Neuroscience of Nicotine, and more (all Elsevier).

Affiliations and Expertise

Professor of Nutritional Biochemistry, Department of Nutrition and Dietetics, Professor of Clinical Biochemistry, Department of Clinical Biochemistry; Director of the Genomics Centre, King’s College, London, UK

Vinood Patel

Dr. Patel is a Reader at the University of Westminster. After completing his PhD at King’s College London, he continued his research experience by undertaking his post-doctoral studies in the laboratory of Professor Cunningham in the Department of Biochemistry at the Wake Forest University School of Medicine, (Winston-Salem, NC, USA). This extensive project involved investigating mechanisms of hepatic mitochondrial ribosome dysfunction in alcoholic liver disease (ALD) using biophysical and proteomic techniques. These studies have led to new avenues in determining the pathology of ALD. His teaching areas at both post-graduate and undergraduate levels include clinical biochemistry, investigative pathology and laboratory investigation.

Affiliations and Expertise

Reader, University of Westminster, London, UK

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