Aging and Other Model Systems

Aging and Other Model Systems

1st Edition - January 1, 1980

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  • Editor: Bert M. Zuckerman
  • eBook ISBN: 9781483259642

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Nematodes as Biological Models, Volume 2: Aging and Other Model Systems contains discussions on free-living nematodes as biological models for pharmacologic and toxicant testing, and for studies on gerontology and nutrition. The book presents specific chapters that cover topics on nematodes as models to study aging; nematodes as nutritional models; physiology and morphology of nematodes; and models and mechanisms on longevity and survival in nematodes. Geneticists, cell and developmental biologists, neurologists, endocrinologists, toxicologists, nutritionists, and gerontologists will find the book invaluable.

Table of Contents

  • Contents

    List of Contributors


    Contents of Volume 1

    Part 1. Aging, Nutritional, and Toxicant Testing Models

    1 Nematodes as Models to Study Aging

    I. Introduction

    II. Aging Studies in Axenic and Monoxenic Culture

    III. Mass Cultures for Aging Research

    IV. Age Pigment

    V. Sex Factors in Longevity and Reproduction

    VI. Influence of Environment on Development and Aging

    VII. Behavioral Changes during Aging

    VIII. Longevity Increases

    IX. Other Aging Parameters

    X. Nematodes to Study Biological Aging in Outer Space

    XI. Summary and Future Research Directions


    2 Effects of Aging on Enzymes

    I. Methods of Aging Nematodes

    II. Alteration of Enzymes in Aged Nematodes

    III. Evaluation of the Nematode Model System


    3 Nematodes as Nutritional Models

    I. Introduction

    II. Nutritional Requirements in the Basal Medium

    III. The Growth Factor

    IV. Nutrient Absorption

    V. Possible Contaminants of Axenic Culture

    VI. Nutrition and Development

    VII. Conclusions and Prospects


    4 Action of Chemical and Physical Agents on Free-Living Nematodes

    I. Introduction

    II. Methods of Assay and Probes

    III. Prospects


    Part 2. Physiology and Morphology

    5 Respiration in Nematodes

    I. Introduction

    II. Diffusion of Oxygen into Nematodes

    III. Oxygen and the Mitochondrion

    IV. Oxygenases

    V. Factors Influencing Oxygen Demand

    VI. Oxygen Availability

    VII. Respiration in Low Oxygen Regimes

    VIII. Hemoglobin

    IX. Anaerobiosis

    X. Conclusions


    6 Osmotic and Ionic Regulation in Nematodes

    I. Introduction

    II. Techniques

    III. Mechanisms in Nematode Osmoregulation and Possible Structures Involved in Transport Processes in Nematodes

    IV. Specialized Aspects of Osmotic and Ionic Regulation in Nematodes

    V. Conclusions


    7 Nematode Energy Metabolism

    I. Introduction

    II. Energy Storage Molecules

    III. Utilization of Energy Reserves

    IV. End Products of Metabolism

    V. Glycolysis and the Tricarboxyclic Acid Cycle

    VI. Other Pathways of Energy Metabolism

    VII. Energy Production and Regulation of Metabolism

    VIII. Conclusions


    8 Longevity and Survival in Nematodes: Models and Mechanisms

    I. Introduction

    II. Model Nematodes for Studying Longevity and Survival

    III. Physiological Aspects of Desiccation Survival

    IV. Conclusions


    9 The Nematode Cuticle and Its Surface

    I. Introduction

    II. Whole Cuticle Structure

    III. The Epicuticle

    IV. Dynamic State of the Epicuticle

    V. Development of the Epicuticle

    VI. Summary and Conclusions


    10 Nematode Sense Organs

    I. Introduction

    II. Cuticular Sense Organs

    III. Internal Sensory Receptors

    IV. Conclusions



Product details

  • No. of pages: 320
  • Language: English
  • Copyright: © Academic Press 1980
  • Published: January 1, 1980
  • Imprint: Academic Press
  • eBook ISBN: 9781483259642

About the Editor

Bert M. Zuckerman

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