Advances in Radiation Biology V14

Relative Radiation Sensitivities of Human Organ Systems. Part II

1st Edition - April 28, 1990
Editor: John Lett
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 5 5 4 6 - 5

Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The… Read more

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Advances in Radiation Biology, Volume 14: Relative Radiation Sensitivities of Human Organ Systems, Part II focuses on radiation sensitivities of particular human organ systems. The sensitivities are then assessed based on the severity and the rapidity in which the effects of radiation manifest. The opening chapter surveys the clinical and experimental data on approaches toward the prevention of bladder complications in clinical radiotherapy. A discussion on HeLa cells, which are of special importance in human cervical cancer therapy, is then presented. In presenting this topic, this book emphasizes radiation sensitivity and radiobiology of tumors of the cervix of the female genital tract. Chapter 3 briefly covers imaging techniques for hypothalamic-pituitary dysfunction diagnosis and introduces hormonal therapy for remarkable improvements in both physical and mental status of patients. The subsequent chapters discuss basic radiobiology of the thyroid in experimental animal and the late effects of therapeutic and low-level radiation in humans. The radiation damages in bone and cartilage and the changes occurring in the various types of vessels during radiation therapy are also discussed. Chapter 7 presents the basic biology of spermatogenesis, as it applies to the understanding of radiation effects. This chapter also explains the studies of rodents, as it applies to subhuman primates and to man. Moreover, it considers as well the mechanisms of radiation damage to the testis, as elucidated by experimental studies of rodents and subhuman primates. Finally, it presents the limited data available on man and discusses these data in terms of the biology of the system known from experimental studies. The concluding chapter describes the features of radiation-induced hepatic injury, ranging from asymptomatic biochemical or a radiographic abnormality to fulminant, fatal hepatic failure. Radiation biologists will greatly benefit from this book, especially those who are involved in dose fractionation in radiation therapy.

Preface

Contents of Volume 12

Relative Radiosensitivity of the Urinary Bladder in Cancer Therapy

I. Introduction

II. Clinical Syndromes in Radiation-Induced Bladder Injury

III. Pathology

IV. Pathophysiology

V. Technical Factors in Prevention of Bladder Injury following Radiotherapy

VI. Neutrons and the Bladder

VII. Chemotherapy and the Bladder

VIII. Radioprotecting Drugs and Pelvic Irradiation

IX. Treatment of Radiation Injuries to the Bladder

X. Conclusion

References

Relative Radiosensitivities of the Female Genital Tract: Tumors of the Cervix Uteri

I. Introduction

II. History of Cervical Cancer Therapy

III. HeLa Cells for Cervical Cancer Experimental Radiotherapy

IV. Cytological and Cell Kinetics Studies of Cervical Cancer

V. Experimental Methods Directed at Tumor Radioresistance

VI. Chemotherapy of Cervical Cancer

VII. Hyperthermia

VIII. Adjuvant Immunotherapy

IX. Histogenesis and Radiosensitivity of Cervical Cancer

X. Prospects for the Future of Cervical Cancer Therapy

References

Hypothalamic-Pituitary Failure after Radiotherapy for Tumors

of the Head and Neck

I. Introduction

II. Diagnostic Tests for the Hypothalamic-Pituitary-Thyroid Axis

III. Comments

References

Radiation Effects on the Thyroid Gland

I. Introduction

II. Thyroid Physiology

III. Radiobiology of the Thyroid Gland in Experimental Animals

IV. Radiation Effects of Radioiodine in Humans

V. Radiation Effects of External-Beam Radiotherapy

VI. Summary

References

Radiation Effects on Bone and Cartilage

I. Introduction

II. Cartilage

III. Bone

IV. Summary and Conclusions

References

The Vascular System

I. Introduction

II. Classification of Blood Vessels

III. Radiation Injury of the Vascular System

IV. Radiation Injury of Lymphatic Vessels

V. Factors Modifying Vascular Injury

VI. Summary

References

Radiation Sensitivity of the Human Testis

I. Introduction

II. Structure of the Testis and Accessory Ducts

III. Proliferative Behavior of Cells in the Normal Testis

IV. Effects of Irradiation on Spermatogenesis

V. Human Studies

References

Radiation Sensitivity of the Liver

I. Introduction

II. Liver Anatomy

III. Pathogenesis

IV. Clinical Results

V. Hepatocarcinogenesis

VI. Experimental Results

VII. Conclusions

References

Index