Description

Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Protein Aggregation.

Key Features

  • Covers reviews of methodology and research in all aspects of protein chemistry
  • Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics

Readership

Biochemists, biophysicists, cell biologists, protein chemists, structural geneticists, and structural biologists

Table of Contents

Nucleic acid-mediated protein aggregation and assembly

I. Introduction

II. Nucleic Acid-Mediated Aggregation of Amyloid Proteins

III. Nucleic Acid Sequestration to Pathological Tissues

IV. Self-Assembly of Protein Nanostructures in the Presence of Nucleic Acids

V. Summary

Aggregation, stability, and formulation of human antibody therapeutics

I. Introduction

II. Expression of Human Monoclonal Antibodies and Antibody Fragments

III. Methods for Analyzing Solubility, Aggregation and Stability of Monoclonal Antibodies

IV. Addressing Aggregation and Increasing Stability of Monoclonal Antibodies

Lysozyme

I. Introduction

II. Amyloid and Amyloidosis

III. Human Lysozyme

IV. Aggregation of Hen Lysozyme In Vitro

V. Recovery and Purification of Lysozyme from Inclusion Bodies

VI. Inhibition of Lysozyme Aggregation

VII. Future Perspectives

Protein aggregation in a membrane environment

I. Introduction

II. The Role of Electrostatics in Membrane-Mediated Protein Aggregation

III. Hydrophobic Effect as Driving Force for Protein Aggregation

IV. Hydrogen-Bonding as Determinant of Protein Aggregation Propensity

V. Experimental Techniques Used to Study Protein Aggregation

VI. Concluding Remarks

Contactins

I. Introduction

II. Genetic Implication of CNTN4, CNTN5, and CNTN6 in Neurodevelopment

III. Expression of Contactins During Brain Development

IV. Phenotypes in Contactin Null-Mutants

V. Structural Architecture of Contactins

VI. Protein–Protein Interactions Mediated by Contactins

VII. Final Remarks

Author Index

Subject Index

Details

No. of pages:
216
Language:
English
Copyright:
© 2011
Published:
Imprint:
Academic Press
Electronic ISBN:
9780123864840
Print ISBN:
9780123864833

About the serial-volume-editor

Rossen Donev

Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2010 Dr. Donev was appointed Lecturer in Swansea University. Currently he is Director of Biomed Consult Ltd, UK. His major research interests include signalling pathways involved in neuropsychiatric disorders and tumour escape from the immune system, and development of therapeutic strategies for treatment. He has published more than 50 research papers, has chaired scientific meetings in Molecular Medicine and given plenary talks at Attention Deficit/Hyperactivity Disorder meetings. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals.

Reviews

"The authority, originality, and editing of the reviews are first class." --Nature