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- Chapter One: Stimuli-Sensitive Liposomes: Lipids as Gateways for Cargo Release
- 1 Introduction
- 2 Currently Available Nanosystems for On-Demand Cargo Release
- 3 Triggering Solely Based on the Properties of the Lipids
- 4 Clinical Status of Triggerable Liposomes and Future Considerations
- Chapter Two: Effect of Lipid Bilayer Composition on Membrane Protein Association
- 1 Introduction
- 2 Computational Methods to Analyze Association
- 3 Association of Single Transmembrane Helices
- 4 GPCR Organization
- 5 A Model for Lipid-Dependent Modulation of Membrane Protein Organization
- Chapter Three: Biomembrane Organization and Function: The Decisive Role of Ordered Lipid Domains
- 1 Why Are Membrane Ordered Domains a Current Research Topic?
- 2 Why Do Lipids Form Ordered Domains?
- 3 What Is the Relevance of Planar Lipid Bilayers and Liposomes for the Study of Ordered Domains?
- 4 How to Better Understand Ordered Domains and Their Function in Cell Membranes?
- 5 What About Bioelectroactive Molecules and Their Redox Behavior?
- 6 Why Study Biomembrane Ordered Domains? An Intriguing Coincidence Between In Vitro and In Vivo Studies
- 7 Concluding Remarks
- Chapter Four: Membrane-Bound Conformations of Antimicrobial Agents and Their Modes of Action
- 1 Introduction
- 2 Models of Antimicrobial Action
- 3 Antimicrobial Agents with Peptide Backbone
- 4 Antimicrobial Agents with Polymer Backbones
- 5 Antimicrobial Polymers with Rigid Backbone
- 6 Discussion
- Chapter Five: Phenomenology Based Multiscale Models as Tools to Understand Cell Membrane and Organelle Morphologies
- 1 Introduction
- 2 Phenomenological Theories for Membranes
- 3 Membrane Remodeling Events as Equilibrium and Nonequilibrium Processes
- 4 Nematic Membrane Model for Protein Driven Membrane Remodeling
- 5 Active Membrane Models for Curvature Fluctuations
- 6 Conclusions
- Chapter Six: Membrane Microvesiculation and its Suppression
- 1 Membrane Curvature and Cell Shape
- 2 Membranous Nanostructures and the Fluid Crystal Mosaic Model
- 3 Mechanisms of Micro and Nanovesiculation
- 4 Observation of Membrane Vesiculation on Giant Phospholipid Vesicles
- 5 Attractive Mediated Interaction Between Membranes is Subject to Bridging Mechanism and Orientational Ordering of Mediating Molecules
- 6 Stability of Narrow Necks
- 7 Suppression of Membrane Vesiculation in Cells
- 8 Clinical Implications of Membrane Budding Suppression
The Elsevier book-series Advances in Planar Lipid Bilayers and Liposomes, provides a global platform for a broad community of experimental and theoretical researchers studying cell membranes, lipid model membranes and lipid self-assemblies from the micro- to the nanoscale. Planar lipid bilayers are widely studied due to their ubiquity in nature and find their application in the formulation of biomimetic model membranes and in the design of artificial dispersion of liposomes. Moreover, lipids self-assemble into a wide range of other structures including micelles and the liquid crystalline hexagonal and cubic phases. Consensus has been reached that curved membrane phases do play an important role in nature as well, especially in dynamic processes such as vesicles fusion and cell communication. Self-assembled lipid structures have enormous potential as dynamic materials ranging from artificial lipid membranes to cell membranes, from biosensing to controlled drug delivery, from pharmaceutical formulations to novel food products to mention a few. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.
- The APLBL book series gives a survey on recent theoretical as well as experimental results on lipid micro and nanostructures.
- In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented.
- An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.
experts in the field of chemistry, physics and biology of lipid micro- and nano-structures and biological membranes, and a podium for non-specialists working on the interdisciplinary front
- No. of pages:
- © Academic Press 2015
- 30th July 2015
- Academic Press
- Hardcover ISBN:
- eBook ISBN:
Aleš Iglič received his B.Sc. and Ph.D. degrees in physics and M.Sc. degree in biophysics from the Department of Physics, and the Ph.D. degree in electrical engineering from the Faculty of Electrical Engineering, all from the University of Ljubljana. He is a Full Professor and the Head of Laboratory of Biophysics of the Faculty of Electrical Engineering at University of Ljubljana. His main research interests are in electrostatics, mechanics and statistical physics of lipid nanostructures and biological membranes. He is devoted to higher education, basic research in biophysics and close contacts to clinical practice. Prof. Iglič was visiting scientist and professor at Åbo Academy University in Turku (Finland), Friedrich Schiller University in Jena (Germany) and Czech Technical University in Prague (Czech Republic). He established collaborations with researchers from different universities across the Europe, USA and India and was supervisor of many M.Sc., Ph.D. and postdoctoral students from Slovenia, Czech Republic, Poland, Iran, Bulgaria, Germany, India and Israel. Since 2009 is the editor of Elsevier book series »Advances in Planar Lipid Bilayers and Liposomes« (APLBL).
Faculty of Electrical Engineering, University of Ljubljana, Slovenia
Michael Rappolt has been appointed as Professor of Lipid Biophysics (School of Food Science and Nutrition) in April 2013. He received his MSc and PhD in physics from the University of Hamburg and achieved his habilitation at the University of Ljubljana in the Faculty of Health Sciences. He was Senior Researcher at the Synchrotron Trieste Outstation (Italy), Institute of Biophysics and Nanosystems Research (Austrian Academy of Sciences), before becoming Assistant Professor at Graz University of Technology. Professor Michael Rappolt is a leading authority on investigating the structure and dynamics of lipid membranes using small-angle X-ray scattering. His recent research activities have concentrated on the study of drug/membrane interactions with potential applications to drug delivery and food. Further research topics concentrate on characterising crystallization processes in food, the investigation of colloid interfaces and the determination of particle structures on the nanoscale. He also seeks to transfer standard measurement techniques applied in food research – such as mechanic (sound and shear) and thermodynamic sample manipulations to synchrotron sites – to understand food on a smaller (nanometre) and faster (microsecond) scale.
University of Leeds, UK
Chandrashekhar V. Kulkarni received his PhD in Chemical Biology from University of London for which he was in receipt of a Marie Curie Early Stage Researcher Fellowship at Imperial College London (2005-2008). Earlier he completed his BSc (1999) and MSc (2001) in Chemistry from Shivaji University Kolhapur, India and started his research career at the National Chemical Laboratory Pune, India. He had a few postdoc stints at University of Graz-Austria, University of Bayreuth-Germany and University of Cambridge-UK during which he worked on a wide range of projects. In March 2013 Dr Kulkarni started ‘Lipid Nanostructures Group’ focussing on highly interdisciplinary and cutting-edge projects. Some of his research interests include complex biomembranes and biomolecule interactions, nanostructured lipid particles as carrier systems, and novel nano-bio-applications of lipid nanostructures. Dr Kulkarni joined the editorial board of APLBL in early 2013 and later as an editor of this book series.
University of Central Lancashire, UK