Advances in Parasitology

Advances in Parasitology

1st Edition - July 14, 2022

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  • Editors: David Rollinson, Russell Stothard
  • Hardcover ISBN: 9780323989497
  • eBook ISBN: 9780323989503

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Description

Advances in Parasitology, Volume 118, the latest release in this ongoing series, includes medical studies of parasites of major influence, along with reviews of more traditional areas, such as zoology, taxonomy and life history. New chapters in this release cover topics such as Parasitic and infectious diseases of African wildlife: The Big Five and Improving Translational Power for Antischistosomal Drug Discovery.

Key Features

  • Informs and updates on all the latest developments in the field of parasitology
  • Includes medical studies of parasites of major influence
  • Features reviews of more traditional areas, such as zoology, taxonomy and life history which help shape current thinking and applications

Readership

PhD students, professors, scientists, health workers, government officers, and policy makers at various levels

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Chapter One: The microscopic five of the big five: Managing zoonotic diseases within and beyond African wildlife protected areas
  • Abstract
  • 1: Introduction
  • 2: The ‘Microscopic Five’
  • 3: Challenges of BTb control at the wildlife-livestock interface: The South African case study
  • 4: Drivers of disease: The Kruger National Park case study
  • 5: Disease knowledge gaps and lessons learnt from African protected areas
  • 6: Communities and conservation
  • 7: Conclusions
  • Acknowledgements
  • References
  • Chapter Two: Improving translational power in antischistosomal drug discovery
  • Abstract
  • 1: Filling the drug pipeline for schistosomiasis
  • 2: Evaluating the importance of S. mansoni isolate origin for early antischistosomal drug discovery
  • 3: The S. mansoni mouse model for drug efficacy testing
  • 4: Infection intensity of the patent S. mansoni mouse model
  • 5: Pharmacokinetic/pharmacodynamic (PK/PD) relationship of selected drugs
  • 6: Concluding remarks
  • Acknowledgements and funding
  • References
  • Chapter Three: Unique thiol metabolism in trypanosomatids: Redox homeostasis and drug resistance
  • Abstract
  • 1: Introduction
  • 2: Trypanothione metabolism
  • 3: Effector proteins of the antioxidant defence: Old and new actors
  • 4: Trypanothione metabolism is linked to cysteine, polyamine, and pentose phosphate pathway
  • 5: The role of redox active compounds and their mechanism in parasites survival
  • 6: Role of thiol metabolism in drug resistance
  • 7: Anti-parasitic potential of molecules targeted against redox metabolism
  • 8: Unsolved questions and future prospects
  • References

Product details

  • No. of pages: 166
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: July 14, 2022
  • Imprint: Academic Press
  • Hardcover ISBN: 9780323989497
  • eBook ISBN: 9780323989503

About the Editors

David Rollinson

David Rollinson
Professor David Rollinson is a Merit Research Scientist at the Natural History Museum in London, where he leads a research team in the Wolfson Wellcome Biomedical Laboratories and directs the WHO Collaborating Centre for schistosomiasis. He has had a long fascination with parasites and the diseases that they cause, this has involved him in many overseas projects especially in Africa. He is on the WHO Expert Advisory Panel of parasitic diseases, the editor of Advances in Parasitology and a former President of the World Federation of Parasitologists. His research group uses a multidisciplinary approach, which combines detailed molecular studies in the laboratory with ongoing collaborative studies in endemic areas of disease, to explore the intriguing world of parasites in order to help control and eliminate parasitic diseases.

Affiliations and Expertise

Merit Research Scientist, The Natural History Museum, London, UK

Russell Stothard

Prof. Russell Stothard is Chair in Medical Parasitology at the Liverpool School of Tropical Medicine, UK

Affiliations and Expertise

Chair in Medical Parasitology, Liverpool School of Tropical Medicine, UK

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