Advances in Nanotechnology-Based Drug Delivery Systems

Advances in Nanotechnology-Based Drug Delivery Systems

1st Edition - June 6, 2022

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  • Editors: Anupam Das Talukdar, Satyajit Sarker, Jayanta Kumar Patra
  • Paperback ISBN: 9780323884501
  • eBook ISBN: 9780323904148

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Description

Advances in Nanotechnology-Based Drug Delivery Systems covers the core concepts and latest research regarding the use of nanoscale materials for the development and application of drug delivery systems. The book introduces the reader to nanotechnology in drug delivery, covering the synthesis, encapsulation techniques, characterization and key properties of nanoscale drug delivery systems. Later chapters review the broad range of target applications, including site-specific delivery of drugs for cardiovascular disease, cancer, bacterial infection, bone regeneration. and much more. This book helps translate advanced research into a clinical setting, analyzing the toxicity and health and safety challenges associated with utilizing nanotechnology in biomedicine. This will be a useful reference for those interested in nano-sized drug delivery in biomedicine, including academics and researchers in materials science, biomedical engineering, pharmaceutical science and related disciplines.

Key Features

  • Provides a clear introduction to nanotechnology in drug delivery, covering key principles, synthesis, characterization and unique properties of nanoscale materials for drug delivery systems<
  • Discusses preclinical, clinical and patented nano-drug delivery systems, enabling the reader to grasp the current state-of-the-art and market
  • Covers a broad range of targets for nanoscale drug delivery systems, such as in neurological disorders, oral disease, renal disease, cancer, skin protection, and much more

Readership

Materials scientists, biomedical engineers and pharmaceutical scientists

Table of Contents

  • Cover Image
  • Title Page
  • Copyright
  • Table of Contents
  • Contributors
  • Preface
  • Chapter 1 Nanotechnology: Scopes and various aspects of drug delivery
  • 1.1 Introduction
  • 1.2 Design of nanotechnology – rooted drug delivery systems
  • 1.3 Liposomes
  • 1.4 Polymeric nanocarriers
  • 1.5 Dendrimer-based nanocarriers
  • 1.6 Quantum dots (QDs)
  • 1.7 Carbon nanotubes (CNTs)
  • 1.8 Miscellaneous types of NPs (e.g., magnetic NPs, silica NPs, metallic NPs)
  • 1.9 Magnetic nanoparticles
  • 1.10 Silica nanoparticles
  • 1.11 Metallic nanoparticles
  • 1.12 Discussion
  • 1.13 Conclusion
  • References
  • Chapter 2 Methods for nanoparticle synthesis and drug delivery
  • 2.1 Introduction
  • 2.2 Classification of techniques for synthesis of nanomaterials
  • 2.3 Functionalization strategies
  • 2.4 Mechanism of functionalization
  • 2.5 Some fabrication techniques for nanodrug delivery system
  • 2.6 Selection of nanomaterials in drug delivery
  • 2.7 Conclusion
  • 2.8 Declaimers
  • References
  • Chapter 3 Characterization of nanoparticles
  • 3.1 Introduction
  • 3.2 Characterization of nanoparticles
  • 3.3 Conclusions
  • Acknowledgment
  • References
  • Chapter 4 Stability of therapeutic nano-drugs during storage and transportation as well as after ingestion in the human body
  • 4.1 Introduction
  • 4.2 Factors contributing to the stability of nanoparticles
  • 4.3 Influence of the type of nanoparticle and core material on the stability
  • 4.4 Improving the stability of nanoparticles by appropriate preparation methods
  • 4.5 Shelf-life of material
  • 4.6 Contribution of stabilizers in the storage of functional nanoparticles
  • 4.7 Ingestion of nanoparticles and their fate
  • 4.8 Transportation of therapeutic nanoparticles
  • 4.9 Influence of biological barriers on nanoparticle transportation
  • 4.10 Receptor-mediated delivery
  • 4.11 Summary
  • Acknowledgments
  • Abbreviations
  • References
  • Chapter 5 Advancements in nanophyto formulations
  • 5.1 Introduction
  • 5.2 Nanomedicine
  • 5.3 Nanoherbal medicine
  • 5.4 Advantages of nanomedicine
  • 5.5 Nanotechnology in various medical disciplines
  • 5.6 Herbal nanomedicines and their advantages
  • 5.7 Conclusions
  • References
  • Chapter 6 Clinical potential of nanotechnlogy as smart therapeutics: A step toward targeted drug delivery
  • 6.1 Inception of nanobiotechnology
  • 6.2 Nanodrug delivery combating various clinical diseases
  • 6.3 Nanodrug and COVID-19 outbreak: Recent highlights into the nanotechnology approach
  • 6.4 Conclusion
  • 6.5 Conflict of Interest
  • Acknowledgement
  • References
  • Chapter 7 Nanotechnology and oral health
  • 7.1 Introduction
  • 7.2 Nanodentistry
  • 7.3 Applications of nanotechnology in oral health
  • 7.4 Conclusions
  • Acknowledgment
  • References
  • Chapter 8 Bone tissue engineering using nanotechnology based drug delivery system
  • 8.1 Introduction
  • 8.2 Types of Nanomaterials
  • 8.3 Inorganic nanomaterials
  • 8.4 Polymeric nanoparticles
  • 8.5 Systems of nanodrugs delivery and its usages in orthopedics
  • 8.6 Nanoparticles-based drug delivery to cure osteodegeneration by improving tissue regeneration
  • 8.7 Prevent infections of bones
  • 8.8 Effect of nanodrugs on immunity and bone implants
  • 8.9 Cytotoxicity of using nanoparticles to bones
  • 8.10 Conclusion
  • References
  • Chapter 9 Nanotechnology based gene delivery strategies towards disease therapy; advances and applications
  • 9.1 Introduction
  • 9.2 Methods of cancer treatment
  • 9.3 Gene therapy
  • 9.4 Nanogene delivery systems
  • 9.5 Use of nanoparticle-based gene delivery in gynecological cancer
  • 9.6 Nanoparticle-based gene delivery in renal diseases
  • 9.7 Nanoparticle-based gene delivery in bone diseases
  • 9.8 Nanoparticle-based gene delivery in the generation of transgenic plants
  • 9.9 Conclusion and future prospects
  • Acknowledgement
  • References
  • Chapter 10 Nanonutrition- and nanoparticle-based ultraviolet rays protection of skin
  • 10.1 Introduction
  • 10.2 Ultraviolet radiation (UVR)
  • 10.3 Human skin – a natural particle barrier
  • 10.4 Sunscreen formulation
  • 10.5 Organic UV filters
  • 10.6 Inorganic UV filters
  • 10.7 Lipid- and surfactant-based nanoparticles for broadband UV protection
  • 10.8 New avenues in UV protection
  • 10.9 Biological and environmental impacts of sunscreen ingredients
  • 10.10 Conclusions
  • 10.11 Future outlooks
  • References
  • Chapter 11 Drug and gene delivery by nanocarriers: Drug delivery process, in brief, using different oxides such as zinc, iron, calcium, polymeric, peptides, and in-vitro drug delivery process by silicon oxide (SiOx) and titanium dioxide (TiO2) nanodots (NDs)
  • 11.1 Introduction
  • 11.2 Glancing angel deposition technique (GLAD)
  • 11.3 Conclusion
  • Uncited references
  • Reference
  • Chapter 12 Uncovering the limitation of nanodrug delivery system: Backdrop to the game changer
  • 12.1 Introduction
  • 12.2 Mechanism of the conventional method of treatment and concept of nanodrugs
  • 12.3 The mechanism of nanodrug delivery
  • 12.4 Cancer and need for nanodrug (present status)
  • 12.5 NPs role cancer therapy
  • 12.6 Challenges in the uptake of the nanodrug
  • 12.7 Conclusion
  • Acknowledgments
  • References
  • Chapter 13 Preclinical, clinical, and patented nanodrug delivery systems
  • 13.1 Background
  • 13.2 Stages of drug development
  • 13.3 Nanomaterials for DDS
  • 13.4 Patented nanodrug delivery systems
  • 13.5 Approved nano-based drug delivery systems
  • 13.6 Conclusion
  • References
  • Chapter 14 Challenges and ­hazards ­associated with ­nanotechnology in agriculture
  • 14.1 Introduction
  • 14.2 Application of NPs in agriculture
  • 14.3 Nanofertilizers
  • 14.4 Nanopesticides
  • 14.5 Using nano weed killer and insecticide in agriculture field
  • 14.6 Future challenges
  • 14.7 Conclusion
  • References
  • Chapter 15 Nanotechnology-based cancer drug delivery
  • 15.1 Introduction
  • 15.2 Nanocarriers used in drug delivery system
  • 15.3 Nanoparticles
  • 15.4 Quantum dots
  • 15.5 Carbon nanotubes
  • 15.6 Liposomes
  • 15.7 Polymeric micelles
  • 15.8 Dendrimers
  • 15.9 Nanowires and nanocantilever
  • 15.10 Conclusion
  • References
  • Chapter 16 Regulatory aspects: Toxicity and safety
  • 16.1 Introduction
  • 16.2 Clinical and toxicological aspects
  • 16.3 Environmental toxicity
  • 16.4 Methodological concerns for evaluating the safety of nanomedicines
  • 16.5 Regulatory aspects
  • 16.6 Future research needs
  • 16.7 Conclusion
  • References
  • Chapter 17 Nanoparticles-based drug delivery to cure osteodegeneration by improving tissue regeneration
  • 17.1 Introduction
  • 17.2 Nanoparticles and its role in osteoporosis
  • 17.3 Conclusion
  • References
  • Chapter 18 Applications of metal oxide nanoparticles in cancer therapy
  • 18.1 Introduction
  • 18.2 Metal oxide nanoparticle synthesis
  • 18.3 Application of metal oxides in different types of cancer
  • 18.4 Conclusion
  • References
  • Chapter 19 Recent approaches of nanodrug delivery and toxicity to untargeted organs
  • 19.1 Introduction
  • 19.2 Routes of nanodrug delivery
  • 19.3 Biodistribution and pharmacokinetics of targeted therapeutics
  • 19.4 Biodistribution
  • 19.5 Cytotoxicity of nanoparticles
  • 19.6 Future of the drug delivery systems
  • 19.7 Conclusion
  • References
  • Chapter 20 Nanomaterials in tissue engineering: Applications and challenges
  • 20.1 Introduction
  • 20.2 Applications of different nanomaterials in the field of tissue engineering
  • 20.3 Application of metallic nanoparticles in tissue engineering
  • 20.4 Conductive polymers
  • 20.5 Carbon nanotubes
  • 20.6 Graphene
  • 20.7 Hydrogels
  • 20.8 Bioceramics
  • 20.9 Different doped elements in biomaterial used for tissue engineering
  • 20.10 Challenges and future perspectives
  • References
  • Chapter 21 Nanocarriers: A boon to the drug delivery systems
  • 21.1 Introduction
  • 21.2 Type/classes of nanocarriers
  • 21.3 Synthesis methods for nanocarriers
  • 21.4 Conclusion
  • References
  • Chapter 22 Nanomaterials in biomedicine: Synthesis and applications
  • 22.1 Introduction
  • 22.2 Conclusion
  • References
  • Chapter 23 Polymeric and metal nanostructures for bone regeneration and osteomyelitis treatment
  • 23.1 Introduction
  • 23.2 Bone regeneration and osteomyelitis treatment
  • 23.2.1 Potential therapeutic agents
  • 23.3 Bone cement structures and material
  • 23.4 Nanostructures for drug release
  • 23.5 Metal antimicrobial bone cements for the therapeutic treatment of osteomyelitis
  • 23.6 Final remarks and future perspectives
  • Acknowledgments and funding
  • References
  • Index

Product details

  • No. of pages: 670
  • Language: English
  • Copyright: © Elsevier 2022
  • Published: June 6, 2022
  • Imprint: Elsevier
  • Paperback ISBN: 9780323884501
  • eBook ISBN: 9780323904148

About the Editors

Anupam Das Talukdar

Dr Anupam Das Talukdar, MSc PhD is an Assistant Professor at the Department of Life Science and Bioinformatics at Assam University, Silchar, India and have 12 years of teaching experience in the area of Phytochemistry He is an Editorial Board member and reviewer for the journal, Phytochemical Analysis. His research focuses on medicinal plants, and bioactive compounds for drug delivery and computer aided drug designing.. Dr Talukdar has edited 4 books and written 24 book chapters on the topic of natural products for medicinal purposes.He has published more than 80 articles in national and international peer reviewed journals covering medicinal plants of North Eastern part of India, bioactivity of phytochemicals , antimicrobial , anticancancer activity and insilico drug designing.Dr.Talukdar has supervised 12 PhD scholar in the area of phytochemistry and CADD and have 4 ongoing research projects funded by different Indian agencies like DBT,UGC and SERB.

Affiliations and Expertise

Assistant Professor,Department of Life Science and Bioinformatics, Assam University, Silchar, India

Satyajit Sarker

Satyajit Sarker
Prof Satyajit Sarker, the Editor-in-Chief of Phytochemical Analysis, and the former President of the Phytochemical Society of Europe (2018-20), is the Director of School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University. He has recently been awarded with an Honorary Professorship at the University of East Anglia (2020-24). He obtained BPharm (Hons) and MPharm degrees from Dhaka University, and completed his PhD in Phytochemistry from Strathclyde University, Glasgow, UK. His research focuses on anticancer, anti-inflammatory, antimalarial, antimicrobial, chemopreventive and wound-healing properties of phytochemicals. Prof Sarker is in the Editorial Board of >35 international journals.

Affiliations and Expertise

Director, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK

Jayanta Kumar Patra

Dr Jayanta Kumar Patra, MSc, PhD, PDF, is an Associate Professor at Dongguk University, Republic of Korea. He has around 14 years of research and teaching experience in the fields of pharmacology and nano-biotechnology. His current research focuses on nanoparticle synthesis by green technology methods and associated biomedical applications: green synthesis of silver, gold, iron, calcium, phosphorous nanoparticles using food waste, agricultural waste and plant materials and evaluation of their antibacterial, antioxidant and cytotoxicity potential. He also focuses on the antibacterial synergistic potential of nanoparticles and conjugation with different antibiotics, drugs etc. along with ethno-medicinal potential of plants. Dr Patra has published >150 articles in various national and international peer-reviewed journals, including Materials Science and Engineering C, Nanomedicine: Nanotechnology, Biology, and Medicine, International Journal of nanomedicine and Journal of Nanobiotechnology and around 35 book chapters. He is editor of 16 books covering nanotechnology in pharmacology, biomedicine and food sciences, including titles published with Apple Academic Press, CRC Press and Springer. He is currently also an editorial board member of >10 international journals, including BMC Complementary and Alternative Medicine, Frontiers in Nanotechnology, Frontiers in Cellular and Infection Microbiology, and Frontiers in Microbiology.

Affiliations and Expertise

Associate Professor, Research Institute of Integrative Life Sciences, Dongguk University, South Korea

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