Description

Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field.

Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

Key Features

  • Cutting-edge reviews by leading workers in the discipline
  • In-depth dissection of molecular aspects of interest to a broad range of scientists, physicians and any student in the allied disciplines
  • Leading edge applications of technological innovations in chemistry, biochemistry and molecular medicine

Readership

For academics in the field of chemistry, biochemistry, toxicology, pharmacology medicine; for Government agencies and those in industry, pharmaceutical and chemical manufacturers

Table of Contents

Contributors

Preface

Chapter One. AHR- and ER-Mediated Toxicology and Chemoprevention

1 Introduction

2 AHR Ligands

3 Aryl Hydrocarbon Receptor

4 Estrogen Receptor α and β

5 Reciprocal AHR–ER Crosstalk

6 ERα-Dependent Regulation of AHR Action

7 Implications for Chemoprevention

8 Summary

References

Chapter Two. Free Radical Metabolites in Arylamine Toxicity

1 Introduction

2 Arylamine Toxicity

3 Arylamines to Nitroaromatics—Six Degrees of Redox Separation

4 Sources and Systems that Generate Free Radical Metabolites from Arylamine Xenobiotics

5 Reactions of Arylamine Radicals with Cellular Antioxidants

6 Reactions Between Arylamine Radicals and DNA

7 Arylamine Drugs and Blood Dyscrasias

8 Diverting Toxic Arylamine Free Radical Generation to Detoxification: Importance of Free Radical Targets

9 Mixtures Toxicology—Application to Arylamine Free Radicals

10 Protein Radicals and Toxicity—Future Prospects

11 Closing Remarks

References

Chapter Three. Genotoxicity of Polycyclic Aromatic Hydrocarbon Metabolites: Radical Cations and Ketones

1 Introduction

2 Exposure to PAHs

3 Exposure Risks of PAH

4 DNA Damage by PAH

5 PAH Metabolism to DNA-Reactive Metabolites

6 Diol-Epoxide Pathway

7 The Radical Cation Pathway

8 Depurinating PAH Adducts and AP Sites

9 Mutagenesis Studies to Address PAH Radical Cations

10 Evidence for AP Site Formation Due to Radical Cations

11 Mutagenicity Studies with B[a]P Radical Cation Products

12 The Quinone Pathway

13 Exposure to OPAHs

14 Biological Relevance of OPAH

15 Conclusion

References

Chapter Four. Nitrogen Oxides Toxicology of the Aerodigestive Tract

Details

No. of pages:
254
Language:
English
Copyright:
© 2013
Published:
Imprint:
Elsevier
Print ISBN:
9780444626455
Electronic ISBN:
9780444626554