Advances in Molecular Pathology, 2019

1st Edition, Volume 2-1 - September 1, 2019
Editor: Gregory J. Tsongalis
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 7 0 9 5 0 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 0 9 5 1 - 4

This issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology.… Read more

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This issue of Advances in Molecular Pathology will provide a comprehensive review of the most current practices, trends, and developments in the field of Molecular Pathology. Publishing on an annual basis, the volume will be divided into 7 sections: Genetics, Hematopathology, Infectious Disease, Pharmacogenomics, Informatics, Solid tumors, and Identity/HLA. Led by Dr. Gregory Tsongalis of Dartmouth University, a team of experienced pathologists from institutions across the country oversee annual topic and expert author selection.

Advances in Molecular Pathology Volume 2.1 Table of Contents

Preface

Molecular Pathology: Unraveling the Underlying Complexities of Human Disease

By Gregory J. Tsongalis

Genetics

The Evolution of Constitutional Sequence Variant Interpretation

By Jessica Mester and Tina Pesaran

The Future of Clinical Diagnosis: Moving Functional Genomics Approaches to the Bedside

By Rini Pauly and Charles E. Schwartz

Genomic Data in the Electronic Health Record

By Nephi A. Walton, Darren K. Johnson, Thomas N. Person, and Srikar Chamala

Hematopathology

Molecular Genetics in Myelodysplasia Outcomes Prognostication

By Lucas H. Rifkin and Eric Y. Loo

Assessing Measurable Residual Disease in Acute Myeloid Leukemia

By Daniel L. Duncan, Joshua F. Zeidner, and Nathan D. Montgomery

Philadelphia-Like Lymphoblastic Leukemia: Approach to Testing in Clinical Laboratories for Diagnosis, Prognosis, and Therapeutic Risk Assessment

By Michelle Afkhami

Myeloid Gene Panel Testing with Correlation to Updated Clinical Practice Guidelines

By Laura N. Toth and Daniel Babu

Infectious Disease

Impact of Molecular Diagnostics on Antimicrobial Stewardship

By Sheila M. Johnson, Mackenzie E. Collins, and Melissa B. Miller

Application of Next-Generation Sequencing in Public Health Epidemiology and Outbreak Investigation

By Anthony Tran and Marie-Claire Rowlinson

Next-Generation Sequencing Approaches to Predicting Antimicrobial Susceptibility Testing Results

By Rebecca Yee and Patricia J. Simner

Pharmacogenomics

Artificial Intelligence and Pharmacogenomics: A Timely Synergy for Individualizing Medicine

By Ravishankar K. Iyer, Arjun P. Athreya, Liewei Wang, and Richard M. Weinshilboum

The Evolution of DNA Sequencing in Pharmacogenomics

By Steven E. Scherer

Consumer-initiated Genetic Testing and Pharmacogenomics

By Ann M. Moyer and Linnea M. Baudhuin

Informatics

Machine Learning in Biology and Medicine

By Javad Noorbakhsh, Harshpreet Chandok, R. Krishna Murthy Karuturi, and Joshy George

Solid Tumors

Clinical Use of Cell-Free DNA in Tumor Diagnostics

By Tejus A. Bale and Maria E. Arcila

Practical Concepts, Current Challenges, and Technological Advances in Clinical Next- Generation Sequencing Assays for Solid Tumors

By Mir B. Alikhan, Mustafa Al-Kawaaz, Karen Kaul, and Linda Sabatini

Evidence Builds for Tumor Mutation Burden as an Immunotherapy Biomarker

By Andrea Ferreira-Gonzalez

Identity/HLA

Human Leukocyte Antigen Typing Using High- Throughput DNA and RNA Sequencing and Application for Cell Line Identification

By Sebastian Boegel and John C. Castle

Expanding the Connectivity Map Concept as the Functional Look-Up Table for Systems Biology

By Bernard Kok Bang Lee, Sok Ching Cheong, and Aik Choon Tan

Gregory J. Tsongalis

Gregory J. Tsongalis, PhD, HCLD, CC, FNACB., is the Vice Chair for Research and the Director of the Laboratory for Clinical Genomics and Advanced Technology (CGAT) in the Department of Pathology and Laboratory Medicine at the Dartmouth-Hitchcock Medical Center and Norris Cotton Cancer Center (NCCC) in Lebanon, NH. He is a Professor of Pathology and Laboratory Medicine at the Audrey and Theodor Geisel School of Medicine at Dartmouth in Hanover, NH and a member of the NCCC Molecular Therapeutics Program and the gastrointestinal and breast cancer clinical oncology groups. In 2016 he became a member of Dartmouth College’s Program in Experimental and Molecular Medicine (PEMM), and he has served on the advisory board of the Health Care Genetics Professional Science Master’s Degree Program and Diagnostic Genetic Sciences Program at the University of Connecticut (Storrs, CT). His area of expertise is in the development and implementation of clinical molecular diagnostic technologies. His research interests are in the pathogenesis of human cancers, personalized medicine and disruptive technologies. He has authored/edited twelve textbooks in the field of molecular pathology, published more than 230 peer reviewed manuscripts, and has been an invited speaker at both national and international meetings. He has served on numerous committees of the American Association for Clinical Chemistry, the American Society for Investigative Pathology, the Federation for American Societies for Experimental Biology, and the Association for Molecular Pathology (where he is a past President). He is active in the Alliance for Clinical Trials in Oncology, the Association for Molecular Pathology, the American Association for Clinical Chemistry, the American Association of Bioanalysts, and the American Society for Investigative Pathology. He serves on the editorial boards of 8 journals including Clinical Chemistry, Experimental and Molecular Pathology, and the Journal of Molecular Diagnostics. In 2016, Dr. Tsongalis received the Norris Cotton Cancer Center Award for Excellence, in 2017 the Association for Molecular Pathology (AMP) Jeffrey A. Kant Leadership Award, and in 2019 the American Society for Investigative Pathology Robbins Distinguished Educator Award. He also serves on numerous corporate scientific advisory boards.

Affiliations and expertise

Laboratory for Clinical Genomics and Advanced Technology (CGAT), Department of Pathology and Laboratory Medicine, Dartmouth, Hitchcock Medical Center and Dartmouth Cancer Center, Lebanon, NH, United States and the Geisel School of Medicine at Dartmouth, Hanover, NH, United States