Advances in Metabolic Disorders

Advances in Metabolic Disorders, Volume 4 covers the developments in the study of metabolic disorders. The book discusses the intestinal factors in the regulation of insulin secretion; antidiuretic hormone synthesis, release, and action under normal and pathological circumstances; and the symptoms, pathophysiology, diagnosis, and clinical syndromes of disaccharide malabsorption. The text also describes the hormonal control of fetal development and metabolism; the placental carbohydrate, fat, and protein metabolism; as well as the metabolic aspects of obesity. The use of liquid formula diets in metabolic studies is also considered. The book will prove invaluable to physicians, endocrinologists, physiologists, and medical students.

Contributors

Preface

Contents of Previous Volumes

Intestinal Factors in the Regulation of Insulin Secretion

I. Introduction

II. Alimentary Augmentation of Insulin Secretion

III. Morphological Considerations

IV. Humoral Factors in the Control of Insulin Secretion; Intestinal Hormones

V. Nonhumoral Factors in the Control of Insulin Secretion

VI. Clinical Implications

VII. Conclusions

References

Antidiuretic Hormone Synthesis, Release, and Action Under Normal and Pathological Circumstance

I. Introduction

II. Chemistry of Antidiuretic Hormone and Its Accompanying Substances in the Secreting Nerve Cells

III. Chemical Synthesis of Vasopressin and Analogs

IV. Synthetic Analogs as Substitutes or Blocking Substances for Antidiuretic Hormone

V. Preparations of Labeled Vasopressin

VI. Biosynthesis of Vasopressin

VII. Determination

VIII. Classification of the Vasopressin-Secreting Cells as Peptidergic Neurons

IX. Can Release of Vasopressin Take Place Independently of Oxytocin Release?

X. Recent Developments concerning Localization and Function of the Antidiuresis-lnducing Osmoreceptors

XI. Effect of Nonosmotic Stimuli on the Function of the Vasopressinergic Cells

XII. Mechanism of Release of Vasopressin from the Neurohypophysis

XIII. Syndrome of Inappropriate Secretion of Antidiuretic Hormone (SIADH)

XIV. Diabetes Insipidus

XV. Recent Developments concerning the Action of Vasopressin

References

Disaccharidase Deficiency

I. Dietary Carbohydrates and Their Products

II. Normal Disaccharide Absorption

III. Disaccharide Malabsorption

IV. Clinical Syndromes of Disaccharide Malabsorption

References

Hormonal Control of Fetal Development and Metabolism

I. Introduction

II. Reckoning Fetal Stages

III. Critical Stages and Permanent Effects in Testicular and Thyroid Physiology

IV. The Anterior Pituitary in Fetal Development

V. The Hormonal Control of Liver Glycogen

VI. Fetal Lipids in Normal and Diabetic Pregnancies

VII. Significance of Birth in Developmental Endocrinology

References

The Metabolism of the Placenta

I. Introduction

II. Carbohydrate Metabolism

III. Lipid Metabolism

IV. Protein Metabolism

V. Epilogue

References

Metabolic Aspects of Obesity

I. Introduction

II. Basic Physiology of Adipose Tissue

III. Metabolic Abnormalities in Obesity

References

The Use of Liquid Formula Diets in Metabolic Studies: 15 Years’ Experience

I. Introduction

II. Advantages of Formula Feeding

III. Patient's Acceptance of a Formula Regimen

IV. Ingredients

V. Formula Preparation, Storage, and Service

VI. Fecal Excretion on a Formula Regimen

VII. Applications in Animal Studies

VIII. Human Energy Requirements, Judged by the Caloric Intake of 114 Adult Patients in the Metabolic Steady State

References

Author Index

Subject Index