Advances in Lipid Research

List of Contributors

Preface

Metabolism of Molecular Species of Diacylglycerophospholipids

I. Introduction

II. Chemical Individuality of Molecular Species of Natural Diacylglycerophospholipids

III. Evidence for Specific Metabolic Functions of Individual Molecular Species of Diacylglycerophospholipids

IV. Biosynthesis of Molecular Species of Diacylglycerophospholipids

V. Alterations in Metabolism of Molecular Species of Diacylglycerophospholipids

VI. Summary and Conclusions

References

Fatty Acids and Immunity

I. Introduction

II. Biosynthesis and Uptake of Fatty Acids by Lymphocytes

III. Fatty Acids as Lymphocyte Components

IV. Role of Free Fatty Acids

V. Fatty Acids in Macrophages

VI. Fatty Acids as Prostaglandin Precursors

VII. Modification of the Immune Response in Vitro and in Vivo by Exogenous Fatty Acids

VIII. Dietary Fatty Acids, Immunity, and Disease

IX. Summary

References

Marginal Vitamin C Deficiency, Lipid Metabolism, and Atherogenesis

I. Introduction

II. Disorders of Lipid Metabolism in Acute Scurvy

III. Model of Chronic Latent Vitamin C Deficiency

IV. Model of Alimentary Hypercholesterolemia and Atherosclerosis in Guinea Pig

V. Vitamin C in Regulation of Cholesterol Turnover

VI. Further Effects of Vitamin C on Lipid Metabolism

VII. Vitamin C, Metabolism of Blood Vessel Wall, and Experimental Atherosclerosis

VIII. Vitamin C, Hyperlipemia, and Atherosclerosis in Man

IX. Conclusions

References

Arterial Enzymes of Cholesteryl Ester Metabolism

I. Introduction

II. Origin and Mechanism of Accumulation of Arterial Cholesteryl Esters

III. Cholesteryl Ester Metabolism in Arteries

IV. Enzymes of Cholesteryl Ester Metabolism

V. Arterial Enzymes in Synthesis and Hydrolysis of Cholesteryl Esters

VI. Arterial Enzymes in Age and Atherosclerosis

VII. Enzymes in Species Resistant or Susceptible to Atherosclerosis

VIII. Effect of Pharmacologically Active Agents on the Enzymes

IX. Conclusions

References

Phospholipase D

I. Introduction

II. General Description of the Reaction

III. Methods of Determining Phospholipase D Activity

IV. Purification Procedures

V. Characteristics of the Catalytic Protein

VI. Occurrence, Distribution, and Some Developmental Aspects

VII. Substrate Specificity

VIII. Modifiers of Enzymatic Activity

IX. Transphosphatidylation or Base Exchange

X. Possible Mechanism and Mode of Action

References

Screening for Inhibitors of Prostaglandin and Thromboxane Biosynthesis

I. Introduction

II. Inhibition of Prostaglandin Synthetase

III. Binding to Albumin

IV. Antiaggregatory Activity and Inhibition of Thromboxane A2 Generation in Aggregating Platelets

V. Conclusions

References

Atherosclerosis, Hypothyroidism, and Thyroid Hormone Therapy

I. Introduction

II. Argument

III. Atherosclerosis, Hypothyroidism, and Thyroid Hormone Therapy

IV. Indications of the Common Occurrence of Subclinical Hypothyroidism

V. Preliminary Summary

VI. The Diagnostic Difficulty

VII. Definition of Hypothyroidism

VIII. The Therapeutic Dilemma

IX. The Coronary Drug Project

X. Studies Relating Hypothyroidism to Atherosclerosis

XI. Dextrothyroxine Studies

XII. Therapeutic Experience

XIII. Cardiac Tolerance for Cholesteropenic Doses of Dextrothyroxine

XIV. Discussion

XV. Bastenie's Summary

XVI. Resolution

XVII. Discussion

References

Author Index

Subject Index

Contents of Previous Volumes