Advances in Immunology

Advances in Immunology

1st Edition - April 23, 2022

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  • Editors: Frederick Alt, Kenneth Murphy
  • eBook ISBN: 9780323989428
  • Hardcover ISBN: 9780323989411

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Description

Advances in Immunology, Volume 153, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology, with this volume covering Regulatory T Cells in Infection and Factor H and Properdin and their regulation.

Key Features

  • Presents current developments and comprehensive reviews in immunology
  • Provides the latest in a longstanding and respected serial on the subject matter
  • Focuses on recent advances in the advancing area of the mechanisms involved in the evolution of regulatory T-cells in infection and Factor H and Properdin and their regulation

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

  • Cover image
  • Title Page
  • Table of Contents
  • Copyright
  • Contributors
  • Chapter One: The role of properdin and Factor H in disease
  • Abstract
  • 1: Introduction
  • 2: Complement system overview
  • 3: Overview of complement regulation
  • 4: Negative regulation of the AP by FH
  • 5: Positive regulation of the AP by properdin
  • 6: Conclusion
  • Acknowledgment
  • References
  • Chapter Two: Becoming aware of γδ T cells
  • Abstract
  • 1: Introduction
  • 2: A TCR-like gene without a known function
  • 3: Activation of γ genes in the thymus
  • 4: Lymphocytes expressing the γ protein on their surface
  • 5: The nature of the δ protein
  • 6: γδ T cells everywhere
  • 7: After the discovery
  • Acknowledgment
  • References

Product details

  • No. of pages: 126
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 23, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323989428
  • Hardcover ISBN: 9780323989411

About the Editors

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Investigator and Director of the Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

Kenneth Murphy

Kenneth M. Murphy works in Washington University School of Medecine, USA.

Affiliations and Expertise

Washington University School of Medecine, USA

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