Advances in Immunology, Volume 122

1st Edition

Editors: Frederick Alt
Print ISBN: 9780128002674
eBook ISBN: 9780128003640
Imprint: Academic Press
Published Date: 14th January 2014
Page Count: 310
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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

Chapter One: Regulation of Immunoglobulin Class-Switch Recombination

1 Overview of Genomic Alterations in B Cells

2 Initiation of CSR: S Regions and Germline Transcription

3 Induction of DNA Lesions in CSR: Essential Requirement of AID

4 Processing of Deaminated DNA: Requirements for BER and MMR Proteins

5 Completion of CSR: Synapsis and End-Joining

6 AID Phosphorylation at Serine-38 and a Role Beyond DNA Deamination

7 Multifaceted Regulation of AID Expression and Activity

8 Targeting of AID to the Ig Loci

9 AID Activity Beyond the Ig Loci

10 Perspectives


Chapter Two: Two Forms of Adaptive Immunity in Vertebrates

1 Introduction

2 Discovery of VLR

3 Structure of VLR Proteins and Genes

4 Functions of VLR and Lymphocyte Lineages

5 Interplay of VLRB and the Complement System

6 Similarities and Differences in the Two Forms of Adaptive Immunity

7 Evolution of Antigen Receptors

8 Concluding Remarks


Chapter Three: Recognition of Tumors by the Innate Immune System and Natural Killer Cells

1 Introduction

2 Innate Cells and Effector Molecules in Tumor Surveillance

3 Germline-Encoded Receptors Implicated in Tumor Surveillance

4 The Immunogenicity of Cancer: How Alterations Common to Cancer Can Result in Detection by Innate Immune Cells

5 Interplay Between Tumors and Innate Lymphocytes

6 Concluding Remarks


Chapter Four: Signaling Circuits in Early B-Cell Development

1 Introduction

2 Moving from the pro-B to the pre-B Stage

3 The Interleukin 7 Receptor

4 The preBCR and Its Autonomous Signaling

5 Lessons from Transgenic and Knockout Mouse Studies

6 Signaling Pathways Controlling pre-B-


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© Academic Press 2014
Academic Press
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About the Editor

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA


"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods