Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

Key features:

* Contributions from leading authorities
* Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

  • Contributors
  • Chapter One Classical and Alternative End-Joining Pathways for Repair of Lymphocyte-Specific and General DNA Double-Strand Breaks
    • 1 Introduction
    • 2 V(D)J Recombination
    • 3 IgH Class-Switch Recombination
    • 4 Classical Nonhomologous DNA End Joining
    • 5 Alternative End Joining
    • 6 Perspective
  • Chapter Two The Leukotrienes: Immune-Modulating Lipid Mediators of Disease
    • 1 Introduction
    • 2 Biosynthesis of LTs
    • 3 LT Receptors
    • 4 LTs in Immune Responses
    • 5 5-LO and LTs in Human Diseases
    • 6 Antileukotriene Drugs
    • 7 Conclusions
  • Chapter Three Gut Microbiota Drives Metabolic Disease in Immunologically Altered Mice
    • 1 Gut Microbiota: The Organ Within the Organ
    • 2 Localization and Restricted Signaling of PRRs Protects against Aberrant Gut Inflammation
    • 3 Role of Microbiota in Metabolic Disease
    • 4 Increased Energy Harvesting by Microbiota in the Development of Metabolic Disease
    • 5 Microbiota-Induced Sub-Clinical Gut Inflammation Causes Metabolic Disease
    • 6 Microbiota Generates Toxic Metabolites from the Diet, Resulting in Metabolic Disease
    • 7 Microbiota-Mediated Metabolic Disease in Absence of Inflammasome Signaling
    • 8 Microbiota-Mediated Metabolic Disease in Absence of Adaptative Immunity
    • 9 Manipulating the Gut Microbiome, Therapeutic Strategies for Obesity
    • 10 Unanswered Questions, Future Directions, and Conclusions
  • Chapter Four What is Unique About the IgE Response?
    • 1 Effector Functions of IgE Antibodies
    • 2 Control of Class Switch Recombination to IgE
    • 3 Direct and Sequential Switching to IgE
    • 4 IgE+ Cells and Germinal Centers
    • 5 Germinal Center Versus Plasma Cell Fates: Bcl6 and Blimp1
    • 6 Studying IgE Responses In Vivo


No. of pages:
© 2012
Academic Press
Print ISBN:
Electronic ISBN:

About the editor

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA


"The series which all immunologists need."--The Pharmaceutical Journal
"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions."--Science
"Deserves a permanent place in biomedical libraries as an aid in research and in teaching."--Journal of Immunological Methods