Advances in Immunology

Advances in Immunology

1st Edition - July 27, 2011

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  • Editor: Frederick Alt
  • eBook ISBN: 9780123877048

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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

    • AID Targeting in Antibody Diversity
      • 1. Introduction
      • 2. Features of AID-Mediated Mutation
      • 3. Transcription is Necessary for AID Targeting
      • 4. DNA Elements, Secondary Structure and Trans-Acting Factors in SHM and CSR
      • 5. Insights From in vitro Studies: ssDNA is the Substrate for AID
      • 6. The Role of Transcriptional Stalling in AID Targeting
      • 7. Concluding Remarks
    • The IgH Locus 3′ Regulatory Region
      • 1. Introduction
      • 2. IgH Loci and Regulatory Elements in Evolution
      • 3. The Unique Structure of the IgH 3′RR
      • 4. 3′RR Activity and Chromatin Conformation During B-Cell Ontogeny
      • 5. Transcription Factors Controlling the IgH 3′RR
      • 6. The IgH 3′RR Orchestrates the Expression of IgH C Genes
      • 7. Mechanism for IgH 3′RR-Mediated Effects: Is it All about Transcription?
      • 8. Regulatory Regions in Other Complex Loci: Lessons for IgH Locus Regulation
      • 9. The IgH 3′RR in Pathology
      • 10. Conclusion
    • Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice
      • 1. Introduction: The CD4/CD8 Lineage Choice
      • 2. Regulation of CD4/CD8 Coreceptor Expression
      • 3. Transcription Factors Regulating Cd4/Cd8 Gene Expression and Lineage Choice of DP Thymocytes
      • 4. Other Transcription Factors Involved in Lineage Choice
      • 5. Regulation of ThPOK Gene Expression
      • 6. Conclusion
      • Acknowledgments
    • Modeling a Complex Disease
      • 1. Multiple Sclerosis: a Heterogeneous Disease to Model
      • 2. The Original Model: EAE
      • 3. T Cell Receptor Transgenic Models and Spontaneous Disease
      • 4. CD8 Cells in MS and EAE
      • 5. Variances of MS: IFNγ Versus IL-17-Mediated MS
      • 6. Genetic Models of Myelin Defects with Similarities to MS
      • 7. New Transgenic Oligodendrocyte Degeneration Models
      • 8. Late Neurodegenerative Phase
      • 9. Perspective and Conclusion
      • Acknowledgments
    • Autoinflammation by Endogenous DNA
      • 1. Introduction
      • 2. DNA Degradation in Apoptotic Cell Death
      • 3. Degradation of DNA in Macrophages
      • 4. Interferon-Dependent Lethal Anemia in DNase II-Deficient Embryos
      • 5. Cytokine-Dependent, but Lymphocyte-Independent, Arthritis
      • 6. Signal Transduction From DNA to Cytokine Production
      • 7. Concluding Remarks
      • Acknowledgments

Product details

  • No. of pages: 184
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: July 27, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123877048

About the Editor

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Investigator and Director of the Program in Cellular and Molecular Medicine, Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA

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