Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists

Table of Contents

  • AID Targeting in Antibody Diversity
    • 1. Introduction
    • 2. Features of AID-Mediated Mutation
    • 3. Transcription is Necessary for AID Targeting
    • 4. DNA Elements, Secondary Structure and Trans-Acting Factors in SHM and CSR
    • 5. Insights From in vitro Studies: ssDNA is the Substrate for AID
    • 6. The Role of Transcriptional Stalling in AID Targeting
    • 7. Concluding Remarks
  • The IgH Locus 3′ Regulatory Region
    • 1. Introduction
    • 2. IgH Loci and Regulatory Elements in Evolution
    • 3. The Unique Structure of the IgH 3′RR
    • 4. 3′RR Activity and Chromatin Conformation During B-Cell Ontogeny
    • 5. Transcription Factors Controlling the IgH 3′RR
    • 6. The IgH 3′RR Orchestrates the Expression of IgH C Genes
    • 7. Mechanism for IgH 3′RR-Mediated Effects: Is it All about Transcription?
    • 8. Regulatory Regions in Other Complex Loci: Lessons for IgH Locus Regulation
    • 9. The IgH 3′RR in Pathology
    • 10. Conclusion
  • Transcriptional and Epigenetic Regulation of CD4/CD8 Lineage Choice
    • 1. Introduction: The CD4/CD8 Lineage Choice
    • 2. Regulation of CD4/CD8 Coreceptor Expression
    • 3. Transcription Factors Regulating Cd4/Cd8 Gene Expression and Lineage Choice of DP Thymocytes
    • 4. Other Transcription Factors Involved in Lineage Choice
    • 5. Regulation of ThPOK Gene Expression
    • 6. Conclusion
    • Acknowledgments
  • Modeling a Complex Disease
    • 1. Multiple Sclerosis: a Heterogeneous Disease to Model
    • 2. The Original Model: EAE
    • 3. T Cell Receptor Transgenic Models and Spontaneous Disease
    • 4. CD8 Cells in MS and EAE
    • 5. Variances of MS: IFNγ Versus IL-17-Mediated MS
    • 6. Genetic Models of Myelin Defects with Similarities to MS
    • 7. New Transgen


No. of pages:
© 2011
Academic Press
eBook ISBN:
Print ISBN:

About the editor

Frederick Alt

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA


"The series which all immunologists need." --The Pharmaceutical Journal

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"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods