Advances in Immunology - 1st Edition - ISBN: 9780123859914, 9780123859921

Advances in Immunology, Volume 111

1st Edition

Editors: Frederick Alt
eBook ISBN: 9780123859921
Hardcover ISBN: 9780123859914
Imprint: Academic Press
Published Date: 13th October 2011
Page Count: 240
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Table of Contents


Early Steps of Follicular Lymphoma Pathogenesis

1. Follicular Lymphoma

2. The Classical Model of Follicular Lymphomagenesis

3. Circulating and Resident t(14;18) Cells Detected in Healthy Individuals are not Naive B-Cells

4. The “Allelic Paradox”: A Particular Immuno/Genophenotype of t(14;18)+ Activated B-Cells Which Does Not Match Any of the Physiological Memory Subsets Present in Blood

5. A Fraction of t(14;18) Cells in Healthy Carriers are Developmentally “Blocked” Follicular Lymphoma-Like Cells (FLLC)

6. BCL2, BCL6, Maturation Arrest, and the Role of the IgM Receptor

7. Trafficking, Early Dissemination, and Progression

8. A Protracted Model of Multi-Hit FL Genesis

9. Perspectives


“A Rose is a Rose is a Rose,” but CVID is Not CVID

1. Introduction

2. Definition and Diagnostic Criteria

3. Epidemiology

4. Pathophysiology/Immunopathology

5. Etiology/Genetics

6. CVID Classification Schemes

7. Clinical Presentation and Complications

8. Management

9. Prognosis and Survival

10. Summary

Role of Activation-Induced Cytidine Deaminase in Inflammation-Associated Cancer Development


1. Introduction: Cancer as a Genetic Disease

2. Nucleotide-Editing Enzymes as Inducers of Mutations

3. Physiologic Roles of AID in Antibody Production

4. Regulation of AID Expression in B Cells

5. Excessive AID Activity and Genetic Alterations Leading to Tumorigenesis

6. Roles of AID in Inflammation-Associated Human Carcinogenesis

7. Role of AID in the Development of Hematopoietic Malignancy

8. Conclusion


Comparative Genomics and Evolution of Immunoglobulin-Encoding Loci in Tetrapods

1. Introduction

2. Structur


Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

Key Features

  • Contributions from leading authorities and industry experts
  • Informs and updates on all the latest developments in the field


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2011
Academic Press
eBook ISBN:
Hardcover ISBN:


"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Ratings and Reviews

About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA