Advances in Immunology - 1st Edition - ISBN: 9780123736369, 9780080469157

Advances in Immunology, Volume 92

1st Edition

Editors: Frederick Alt
Hardcover ISBN: 9780123736369
eBook ISBN: 9780080469157
Imprint: Academic Press
Published Date: 6th November 2006
Page Count: 344
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Table of Contents

  • Contributors to Volume 92
    • Publisher Summary
  • Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
    • Abstract
    • 1 Introduction
    • 2 Immunological Alterations in SLE
    • 3 Genetics of SLE Susceptibility in Humans
    • 4 Murine Models of SLE
    • 5 Modeling Disease Development
  • Avian Models with Spontaneous Autoimmune Diseases
    • Abstract
    • 1 Introduction
    • 2 Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders
    • 3 The OS Chicken: Model for Human Hashimoto Disease
    • 4 The UCD‐200 Line of Chickens: A Model for Human Systemic Sclerosis
    • 5 The SL Chicken Model for Human Autoimmune Vitiligo
    • 6 Conclusions and Outlook
    • Acknowledgments
  • Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
    • Abstract
    • 1 Introduction
    • 2 Phenotype of CD4+CD25+ nTreg Cells
    • 3 Factors Regulating the Expansion and Specificity of nTreg Cells
    • 4 Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells
    • 5 Growth Factor–Mediated Control of nTreg Cell Development, Function, and Homeostasis
    • 6 Control of Autoimmune Responses by nTreg Cells
    • 7 Summary and Conclusions
    • Acknowledgments
  • BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation
    • Abstract
    • 1 Overview of BTLA and HVEM Ligand Discovery
    • 2 Structural Characterization of BTLA Bound to HVEM
    • 3 Viral Modulators of the HVEM–BTLA Pathway
    • 4 Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs
    • 5 Mechanisms of the CD28 Family Inhibitory Receptors
    • 6 Consequences of HVEM Ligation
    • 7 BTLA and HVEM in Models of Disease
    • 8 Conclusions
  • The Human T Cell Response to Melanoma Antigens
    • Abstract
    • 1 Introduction
    • 2 Melanoma Antigens
    • 3 Measurement of Antigen‐Specific T Cell Responses
    • 4 Naturally Acquired Tumor Antigen‐Specific T Cell Responses
    • 5 Vaccine‐Induced T Cell Responses
    • 6 Regulation of Tumor Antigen‐Specific T Cell Responses
    • 7 Conclusions
    • Acknowledgments
  • Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions
    • Abstract
    • 1 Host–Pathogen Interactions
    • 2 Manipulation of the Host Response by Pathogens: Some General Considerations
    • 3 Antigen Presentation
    • 4 Class I MHC Antigen Presentation
    • 5 Pathogen Recognition by CD8+ T Cells and NK Cells
    • 6 Class II MHC Antigen Presentation
    • 7 Ubiquitin‐Proteasome System
    • 8 The Ubiquitin Conjugation Cascade
    • 9 Ubiquitin Ligases
    • 10 Ubiquitin Chains and Ubiquitin‐Like Modifiers (Ubls)
    • 11 Deubiquitinating Enzymes
    • 12 The Proteasome
    • 13 ER Quality Control and Degradation
    • 14 ERAD Substrate Recognition
    • 15 ERAD E3 Ligases
    • 16 Mammalian ERAD E3s
    • 17 The Elusive Dislocon
    • 18 Driving Dislocation and the Ub‐Binding Route to the Proteasome
    • 19 Peptide N‐Glycanase
    • 20 Viral Interference with Class I MHC Antigen Presentation
    • 21 Human Cytomegalovirus
    • 22 HCMV Interference with Class I MHC Antigen Presentation
    • 23 Dislocation from the ER: HCMV US11 and US2
    • 24 Signal Peptide Peptidase Is Required for Dislocation from the ER
    • 25 SPP and Generation of HLA‐E Epitopes
    • 26 SPP and Processing of the Hepatitis C Virus Core Protein
    • 27 SPP and Calmodulin Signaling
    • 28 SPP Peptide Peptidase and Development
    • 29 SPP and ER Quality Control
    • 30 Three Routes of Pathogen‐Mediated ER Protein Disposal
    • 31 Pathogen Interference with Class II MHC Antigen Presentation
    • 32 Inhibition of Recognition at the Surface of the APC
    • 33 Class II MHC Downregulation from the Surface of the APC
    • 34 CD4 Downregulation from the Surface of the CD4+ T Cell
    • 35 Pathogen Manipulation of the Ubiquitin‐Proteasome System
    • 36 Interference with Proteasomal Proteolysis
    • 37 Control of Infection
    • 38 Virus Budding
    • 39 Bacterial Chromosome Integration
    • 40 ISGylation and deISGylation
    • 41 Control of Inflammation
    • 42 Posttranscriptional Gene Silencing
    • 43 Downregulation of Cell Surface Receptors by Pathogen‐Encoded E3s
    • 44 Programmed Cell Death in Plants
    • 45 Cytokine Responses
    • 46 Pathogen‐Encoded DUBs
    • 47 Conclusions and Future Directions
    • Acknowledgments
  • Index
    • Publisher Summary
  • Contents of Recent Volumes

Description

  • Contributors to Volume 92
    • Publisher Summary
  • Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease
    • Abstract
    • 1 Introduction
    • 2 Immunological Alterations in SLE
    • 3 Genetics of SLE Susceptibility in Humans
    • 4 Murine Models of SLE
    • 5 Modeling Disease Development
  • Avian Models with Spontaneous Autoimmune Diseases
    • Abstract
    • 1 Introduction
    • 2 Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders
    • 3 The OS Chicken: Model for Human Hashimoto Disease
    • 4 The UCD‐200 Line of Chickens: A Model for Human Systemic Sclerosis
    • 5 The SL Chicken Model for Human Autoimmune Vitiligo
    • 6 Conclusions and Outlook
    • Acknowledgments
  • Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity
    • Abstract
    • 1 Introduction
    • 2 Phenotype of CD4+CD25+ nTreg Cells
    • 3 Factors Regulating the Expansion and Specificity of nTreg Cells
    • 4 Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells
    • 5 Growth Factor–Mediated Control of nTreg Cell Development, Function, and Homeostasis
    • 6 Control of Autoimmune Responses by nTreg Cells
    • 7 Summary and Conclusions
    • Acknowledgments
  • BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation
    • Abstract
    • 1 Overview of BTLA and HVEM Ligand Discovery
    • 2 Structural Characterization of BTLA Bound to HVEM
    • 3 Viral Modulators of the HVEM–BTLA Pathway
    • 4 Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs
    • 5 Mechanisms of the CD28 Family Inhibitory Receptors
    • 6 Consequences of HVEM Ligation
    • 7 BTLA and HVEM in Models of Disease
    • 8 Conclusions
  • The Human T Cell Response to Melanoma Antigens
    • Abstract
    • 1 Introduction
    • 2 Melanoma Antigens
    • 3 Measurement of Antigen‐Specific T Cell Responses
    • 4 Naturally Acquired Tumor Antigen‐Specific T Cell Responses
    • 5 Vaccine‐Induced T Cell Responses
    • 6 Regulation of Tumor Antigen‐Specific T Cell Responses
    • 7 Conclusions
    • Acknowledgments
  • Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions
    • Abstract
    • 1 Host–Pathogen Interactions
    • 2 Manipulation of the Host Response by Pathogens: Some General Considerations
    • 3 Antigen Presentation
    • 4 Class I MHC Antigen Presentation
    • 5 Pathogen Recognition by CD8+ T Cells and NK Cells
    • 6 Class II MHC Antigen Presentation
    • 7 Ubiquitin‐Proteasome System
    • 8 The Ubiquitin Conjugation Cascade
    • 9 Ubiquitin Ligases
    • 10 Ubiquitin Chains and Ubiquitin‐Like Modifiers (Ubls)
    • 11 Deubiquitinating Enzymes
    • 12 The Proteasome
    • 13 ER Quality Control and Degradation
    • 14 ERAD Substrate Recognition
    • 15 ERAD E3 Ligases
    • 16 Mammalian ERAD E3s
    • 17 The Elusive Dislocon
    • 18 Driving Dislocation and the Ub‐Binding Route to the Proteasome
    • 19 Peptide N‐Glycanase
    • 20 Viral Interference with Class I MHC Antigen Presentation
    • 21 Human Cytomegalovirus
    • 22 HCMV Interference with Class I MHC Antigen Presentation
    • 23 Dislocation from the ER: HCMV US11 and US2
    • 24 Signal Peptide Peptidase Is Required for Dislocation from the ER
    • 25 SPP and Generation of HLA‐E Epitopes
    • 26 SPP and Processing of the Hepatitis C Virus Core Protein
    • 27 SPP and Calmodulin Signaling
    • 28 SPP Peptide Peptidase and Development
    • 29 SPP and ER Quality Control
    • 30 Three Routes of Pathogen‐Mediated ER Protein Disposal
    • 31 Pathogen Interference with Class II MHC Antigen Presentation
    • 32 Inhibition of Recognition at the Surface of the APC
    • 33 Class II MHC Downregulation from the Surface of the APC
    • 34 CD4 Downregulation from the Surface of the CD4+ T Cell
    • 35 Pathogen Manipulation of the Ubiquitin‐Proteasome System
    • 36 Interference with Proteasomal Proteolysis
    • 37 Control of Infection
    • 38 Virus Budding
    • 39 Bacterial Chromosome Integration
    • 40 ISGylation and deISGylation
    • 41 Control of Inflammation
    • 42 Posttranscriptional Gene Silencing
    • 43 Downregulation of Cell Surface Receptors by Pathogen‐Encoded E3s
    • 44 Programmed Cell Death in Plants
    • 45 Cytokine Responses
    • 46 Pathogen‐Encoded DUBs
    • 47 Conclusions and Future Directions
    • Acknowledgments
  • Index
    • Publisher Summary
  • Contents of Recent Volumes

Readership

Immunologists and infectious disease specialists, cell biologists and hematologists


Details

No. of pages:
344
Language:
English
Copyright:
© Academic Press 2006
Published:
Imprint:
Academic Press
eBook ISBN:
9780080469157
Hardcover ISBN:
9780123736369

About the Editors

Frederick Alt Editor

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA