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Advances in Immunology - 1st Edition - ISBN: 9780123736369, 9780080469157

Advances in Immunology, Volume 92

1st Edition

Editor: Frederick Alt
Hardcover ISBN: 9780123736369
eBook ISBN: 9780080469157
Imprint: Academic Press
Published Date: 6th November 2006
Page Count: 344
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Table of Contents

    <li>Contributors to Volume 92<ul><li>Publisher Summary</li></ul></li> <li>Systemic Lupus Erythematosus: Multiple Immunological Phenotypes in a Complex Genetic Disease<ul><li>Abstract</li><li>1 Introduction</li><li>2 Immunological Alterations in SLE</li><li>3 Genetics of SLE Susceptibility in Humans</li><li>4 Murine Models of SLE</li><li>5 Modeling Disease Development</li></ul></li> <li>Avian Models with Spontaneous Autoimmune Diseases<ul><li>Abstract</li><li>1 Introduction</li><li>2 Chicken Genomics and Its Application to the Genetic Dissection of Autoimmune Disorders</li><li>3 The OS Chicken: Model for Human Hashimoto Disease</li><li>4 The UCD&#x2010;200 Line of Chickens: A Model for Human Systemic Sclerosis</li><li>5 The SL Chicken Model for Human Autoimmune Vitiligo</li><li>6 Conclusions and Outlook</li><li>Acknowledgments</li></ul></li> <li>Functional Dynamics of Naturally Occurring Regulatory T Cells in Health and Autoimmunity<ul><li>Abstract</li><li>1 Introduction</li><li>2 Phenotype of CD4<sup>+</sup>CD25<sup>+</sup> nTreg Cells</li><li>3 Factors Regulating the Expansion and Specificity of nTreg Cells</li><li>4 Innate and Adaptive Inflammatory Signals Dictating the Function of nTreg Cells</li><li>5 Growth Factor&#x2013;Mediated Control of nTreg Cell Development, Function, and Homeostasis</li><li>6 Control of Autoimmune Responses by nTreg Cells</li><li>7 Summary and Conclusions</li><li>Acknowledgments</li></ul></li> <li>BTLA and HVEM Cross Talk Regulates Inhibition and Costimulation<ul><li>Abstract</li><li>1 Overview of BTLA and HVEM Ligand Discovery</li><li>2 Structural Characterization of BTLA Bound to HVEM</li><li>3 Viral Modulators of the HVEM&#x2013;BTLA Pathway</li><li>4 Expression and Regulation of BTLA, LIGHT, and HVEM on T Cells and APCs</li><li>5 Mechanisms of the CD28 Family Inhibitory Receptors</li><li>6 Consequences of HVEM Ligation</li><li>7 BTLA and HVEM in Models of Disease</li><li>8 Conclusions</li></ul></li> <li>The Human T Cell Response to Melanoma Antigens<ul><li>Abstract</li><li>1 Introduction</li><li>2 Melanoma Antigens</li><li>3 Measurement of Antigen&#x2010;Specific T Cell Responses</li><li>4 Naturally Acquired Tumor Antigen&#x2010;Specific T Cell Responses</li><li>5 Vaccine&#x2010;Induced T Cell Responses</li><li>6 Regulation of Tumor Antigen&#x2010;Specific T Cell Responses</li><li>7 Conclusions</li><li>Acknowledgments</li></ul></li> <li>Antigen Presentation and the Ubiquitin&#x2010;Proteasome System in Host&#x2013;Pathogen Interactions<ul><li>Abstract</li><li>1 Host&#x2013;Pathogen Interactions</li><li>2 Manipulation of the Host Response by Pathogens: Some General Considerations</li><li>3 Antigen Presentation</li><li>4 Class I MHC Antigen Presentation</li><li>5 Pathogen Recognition by CD8<sup>+</sup> T Cells and NK Cells</li><li>6 Class II MHC Antigen Presentation</li><li>7 Ubiquitin&#x2010;Proteasome System</li><li>8 The Ubiquitin Conjugation Cascade</li><li>9 Ubiquitin Ligases</li><li>10 Ubiquitin Chains and Ubiquitin&#x2010;Like Modifiers (Ubls)</li><li>11 Deubiquitinating Enzymes</li><li>12 The Proteasome</li><li>13 ER Quality Control and Degradation</li><li>14 ERAD Substrate Recognition</li><li>15 ERAD E3 Ligases</li><li>16 Mammalian ERAD E3s</li><li>17 The Elusive Dislocon</li><li>18 Driving Dislocation and the Ub&#x2010;Binding Route to the Proteasome</li><li>19 Peptide N&#x2010;Glycanase</li><li>20 Viral Interference with Class I MHC Antigen Presentation</li><li>21 Human Cytomegalovirus</li><li>22 HCMV Interference with Class I MHC Antigen Presentation</li><li>23 Dislocation from the ER: HCMV US11 and US2</li><li>24 Signal Peptide Peptidase Is Required for Dislocation from the ER</li><li>25 SPP and Generation of HLA&#x2010;E Epitopes</li><li>26 SPP and Processing of the Hepatitis C Virus Core Protein</li><li>27 SPP and Calmodulin Signaling</li><li>28 SPP Peptide Peptidase and Development</li><li>29 SPP and ER Quality Control</li><li>30 Three Routes of Pathogen&#x2010;Mediated ER Protein Disposal</li><li>31 Pathogen Interference with Class II MHC Antigen Presentation</li><li>32 Inhibition of Recognition at the Surface of the APC</li><li>33 Class II MHC Downregulation from the Surface of the APC</li><li>34 CD4 Downregulation from the Surface of the CD4<sup>+</sup> T Cell</li><li>35 Pathogen Manipulation of the Ubiquitin&#x2010;Proteasome System</li><li>36 Interference with Proteasomal Proteolysis</li><li>37 Control of Infection</li><li>38 Virus Budding</li><li>39 Bacterial Chromosome Integration</li><li>40 ISGylation and deISGylation</li><li>41 Control of Inflammation</li><li>42 Posttranscriptional Gene Silencing</li><li>43 Downregulation of Cell Surface Receptors by Pathogen&#x2010;Encoded E3s</li><li>44 Programmed Cell Death in Plants</li><li>45 Cytokine Responses</li><li>46 Pathogen&#x2010;Encoded DUBs</li><li>47 Conclusions and Future Directions</li><li>Acknowledgments</li></ul></li> <li>Index<ul><li>Publisher Summary</li></ul></li> <li>Contents of Recent Volumes</li>


Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.


Immunologists and infectious disease specialists, cell biologists and hematologists


No. of pages:
© Academic Press 2006
6th November 2006
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Editor

Frederick Alt

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.

Affiliations and Expertise

Howard Hughes Medical Institute Research Laboratories, The Children's Hospital, Boston, MA, USA