Advances in Chemotherapy, Volume 2 provides comprehensive and authoritative surveys of progress in all fields of experimental and applied chemotherapy.
This book is composed of six chapters, and begins with a discussion on the chemical control of nematodes in plants and the chemistry, biochemistry, and anti-infectious properties of cephalosporin group antibiotics. The succeeding chapters describe the antineoplastic activity of olivomycin group antibiotics; the chemotherapeutic action against malignancies of purines and pyrimidines; and the specific relation of these structures to nucleic acids and cell nuclei, which extends the range of activity of these compounds to viral and protozoan infections. These topics are followed by a presentation of the application of chemotherapy to neoplastic diseases of man, with an emphasis on the complex field of drug response in acute leukemia. The final chapters consider the special problems that are involved in the chemotherapy of tuberculosis as applied in developing countries, particularly in India. This book will be of value to chemists and medical biologists.
List of Contributors Preface Systemic Control of Plant Nematodes I. Introduction II. Chemicals Mobile in Plants III. Biochemistry of Nematode Disease IV. Naturally Arising Resistance Factors V. Chemotherapeutic Treatments VI. Conclusions References The Cephalosporins I. Introduction II. History of the Cephalosporins III. Cephalosporin P IV. Penicillin N (Cephalosporin N) and Cephalosporin C V. Conclusions References Metabolic Basis for the Actions of Analogs of Purines and Pyrimidines I. Introduction II. Mechanisms of Drug Action III. Effects of Host on Drug; Drug Metabolism IV. Effects of Drug on Host V. Drugs, Parasites, and Hosts VI. Conclusion References Olivomycin, Mithramycin, Chromomycin: Three Related Cancerostatic Antibiotics I. Introduction II. Microbiology, Chemistry, and Mode of Action III. Pharmacology IV. Antitumor Activity V. Clinical Investigations VI. Conclusions References Recent Advances in the Chemotherapy of Tuberculosis I. Introduction II. Modern Standard Therapy III. The Roles of Sanatorium Treatment and Ambulatory Chemotherapy IV. Isoniazid Alone V. Thiacetazone (Thioacetazone) VI. Intermittent Chemotherapy VII. Reserve Regimens VIII. Conclusion References Progress and Perspectives in the Chemotherapy of Acute Leukemia I. Introduction II. Past Progress in the Chemotherapy of Acute Leukemia III. Current Research and Future Progress References Author Index Subject Index
- No. of pages:
- © Academic Press 1965
- 1st January 1965
- Academic Press
- eBook ISBN:
Clinical Research Centre, Harrow, Middlesex, England