Advances in Chemotheraphy

List of Contributors

Preface

Historical Perspectives in Chemotherapy

Quantitative Concepts in the Clinical Study of Drugs

I. Introduction

II. Preclinical Studies

III. Clinical Considerations

IV. Summary

References

Mechanisms of Action of Phenanthridine and Aminoquinaldine Trypanocides

I. Introduction

II. Trypanosomiasis in Africa: Present-Day Aspects

III. Problems Peculiar to Studies of the Mode of Action of Trypanocides: Blood-Stream and Culture Forms of Trypanosomes

IV. Use of an Insect Flagellate as a Test System for Studies on Drug Action: Advantages and Limitations

V. Drugs in Use for Treatment of Trypanosomiasis in Cattle

VI. Characteristics of the Trypanocidal Action of Phenanthridines and Aminoquinaldines: In Vivo Studies

VII. In Vitro Studies Using Crithidia oncopelti as Test Organism

VIII. Effects of Phenanthridines on Other Cell Systems

IX. Drug Resistance to Phenanthridines and Aminoquinaldines

X. Mechanisms of Action and the Problem of Selective Toxicity: Conclusions and Speculations

References

Chemoprophylaxis and Chemotherapy of Viral Diseases

I. Introduction

II. Factors Influencing Recovery from Viral Diseases

III. Materials with Chemoprophylactic or Chemotherapeutic Activity

IV. Tumor Viruses

V. Comment

References

The Vinca Alkaloids


1. General Introduction

II. Preparation, Chemistry, and Structural Relationships

III. Experimental Biological Properties

IV. Clinical Experiences

V. Summary

References

Cell Culture and Cancer Chemotherapy

I. Introduction

II. Methods

III. Cell Lines

IV. Nutritional and Biochemical Studies

V. Growth-Regulatory Factors

VI. Maintenance and Loss of Specific Functional Capacities

VII. Mammalian Cell Cultures as an Assay for Potential Antitumor Activity

VIII. Organ Culture

IX. Comment

References

Immunoreactions in Antiparasitic Chemotherapy

I. Introduction

II. Components of the Drug-Host-Parasite Complex

III. Immunoreactions in Experimental Antiparasitic Chemotherapy

IV. Immunoreactions in Antiparasitic Chemotherapy in the Clinic and in the Field

References

Drug Synergism in Antineoplastic Chemotherapy

I. The Concept of Therapeutic Synergism

II. Parameters of Response to Therapy of Neoplastic Disease

III. The Pharmacological and Therapeutic Bases for Synergism

IV. The Biochemical Basis for Antitumor Synergism

V. Combination Chemotherapy of Cancer Patients

VI. Conclusions

References

New Concepts of the Use of Inhibitors in Chemotherapy

I. The Classical Antimetabolite Approach

II. New Inhibitors Based on Allosteric Inhibition

III. Enzyme Subunits and Allosteric Phenomena

IV. Multiple Forms of Enzymes

V. Sulfanilamide Inhibition and Folic Acid Synthesis

VI. Virus-Induced Enzymes

VII. Lethal Synthesis and Feedback Inhibition

VIII. DPN Analogs

IX. Homofolate

X. New Inhibitors that Interfere with or Redirect Information Transfer

XI. Mechanism of Actinomycin Inhibition

XII. Hormone Effects

XIII. Specific Inhibition of DNA Replication

XIV. Drugs that Directly Influence Mitotic Processes

XV. Conclusion

References

Author Index

Subject Index