Advances in Cellular Neurobiology

List of Contributors

Preface

Contents of Previous Volumes

Section 1. Cell Differentiation and Interaction

Cell Division in the Normal Central Nervous System

I. Introduction

II. Neural Epithelium. Ventricular and Subventricular Layers

III. Mitotic Cells of Ectodermal Origin

IV. Mitotic Cells of Mesodermal Origin

V. Conclusions

References

Schwann Cells: an In Vitro Perspective

I. Introduction

II. In Vitro Systems

III. Control ofSchwann Cell Proliferation

IV. Myelin-Related Behaviors In Vitro

V. Schwann Cell Influences Directed to Neurons

VI. Conclusions and Projections

References

Molecular and Cell Biological Aspects of Learning: Toward a Theory of Memory

I. Introduction

II. Studies of Biochemical Correlates of Learning

III. Neurochemical Behavioral Modulating Factors

IV. Long-Term Potentiation as a Model System for Learning

V. Studies of Neuroanatomical Changes

VI. Current Status and Theoretical Concepts

References

Section 2. Aging and Pathology

Immunocytochemical Studies of Astrocytes in Normal Development and Disease

I. Introduction

II. The GlialFibrillary Acidic Protein

III. Relation ofGlial Filaments to Neurofilaments and Microtubules

IV. Function of GFA Protein

V. Functions of GFA Protein-Containing Cells

VI. GFA Protein Immunocytochemistry and Retrospective Pathology

References

Aging of Autonomic Synapses

I. Aging of Autonomie Synapses: Some Basic Questions

II. Aging of Autonomie Neurons: A Background

III. Age-Dependent Modifications of Axonal Transport

IV. The Chicken as an Animal Model of Aging

V. Acetylcholine Metabolism in Aging Avian Synapses

VI. Catecholamine Metabolism in Aging Avian Synapses

VII. Aging of Noradrenergic Neurons: A Comparison of CNS and PNS

VIII. Common Characteristics of Cholinergic and Adrenergic Terminals during Aging

IX. Variations in Cholinergic Receptors with Aging. CNS versus PNS

X. Development and Aging of Synapses: A Single Process?

XI. Conclusions: Toward a Pharmacology of Aging Synapses

References

Axonal Elongation in Peripheral and Central Nervous System Transplants

I. Introduction

II. Regeneration in the Peripheral and Central Nervous Systems

III. Transplants of Nonneuronal Cells

IV. Transplantation of Neurons and Target Tissues

V. Discussion

References

Demyelination

I. Introduction

II. Myelin

III. Animal Models of Immunologically Mediated Demyelination

IV. Tissue Culture Studies of Demyelination

V. Conclusions

References

CNS Hypomyelinated Mutant Mice: Morphological and Tissue Culture Studies

I. Introduction

II. Historical Background

III. The Common Clinical Syndrome

IV. Genetics and Morphology of Specific Mutations

V. Experimental Analysis: The Tissue Culture System

References

Section 3. Methodologies

Progress in Cerebral Micro-vascular Studies Related to the Function of the Blood-Brain Barrier

I. Introduction

II. Endothelial Cell Cultures

III. CerebralMicrovessels

IV. Conclusions

References

Isolation and Characterization of the Cells of the Cerebral Microvessels

I. Introduction

II. Isolation of Microvessels

III. Culture of Vessels and Derived Cells

IV. Studies on Cells Derived from Microvessels

V. Concluding Remarks

References

PCI2 Pheochromocytoma Cultures in Neurobiological Research

I. Introduction

II. Historical Background

III. The Classification of PC12 Cells

IV. Chromaffin Cell-like Properties of PC12 Cells

V. Responses to NGF

VI. The Developmental Significance of the PC12 Line

VII. Applications of PC12 Cells

VIII. Practical Aspects of the Growth and Maintenance of PC12 Cells

IX. Addendum

References

Index