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Advances in Cellular Neurobiology - 1st Edition - ISBN: 9780120083039, 9781483266930

Advances in Cellular Neurobiology

1st Edition

Volume 3

Editors: Sergey Fedoroff Leif Hertz
Hardcover ISBN: 9780120083039
eBook ISBN: 9781483266930
Paperback ISBN: 9781483234823
Imprint: Academic Press
Published Date: 28th January 1982
Page Count: 436
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Advances in Cellular Neurobiology, Volume 3 discusses the anatomy and functional relation of the brain and spinal cord. This book is divided into three main sections—cell differentiation and interaction, aging and pathology, and methodologies. The topics discussed include Schwann cells, an in vitro perspective; molecular and cell biological aspects of learning toward a theory of memory; and aging of autonomic synapses. The axonal elongation in peripheral and central nervous system transplants; isolation and characterization of the cells of the cerebral microvessels; and PCI2 pheochromocytoma cultures in neurobiological research are also deliberated in this text. This publication is intended for neurologists, but is also beneficial to students researching on the central nervous system.

Table of Contents

List of Contributors


Contents of Previous Volumes

Section 1. Cell Differentiation and Interaction

Cell Division in the Normal Central Nervous System

I. Introduction

II. Neural Epithelium. Ventricular and Subventricular Layers

III. Mitotic Cells of Ectodermal Origin

IV. Mitotic Cells of Mesodermal Origin

V. Conclusions


Schwann Cells: an In Vitro Perspective

I. Introduction

II. In Vitro Systems

III. Control ofSchwann Cell Proliferation

IV. Myelin-Related Behaviors In Vitro

V. Schwann Cell Influences Directed to Neurons

VI. Conclusions and Projections


Molecular and Cell Biological Aspects of Learning: Toward a Theory of Memory

I. Introduction

II. Studies of Biochemical Correlates of Learning

III. Neurochemical Behavioral Modulating Factors

IV. Long-Term Potentiation as a Model System for Learning

V. Studies of Neuroanatomical Changes

VI. Current Status and Theoretical Concepts


Section 2. Aging and Pathology

Immunocytochemical Studies of Astrocytes in Normal Development and Disease

I. Introduction

II. The GlialFibrillary Acidic Protein

III. Relation ofGlial Filaments to Neurofilaments and Microtubules

IV. Function of GFA Protein

V. Functions of GFA Protein-Containing Cells

VI. GFA Protein Immunocytochemistry and Retrospective Pathology


Aging of Autonomic Synapses

I. Aging of Autonomie Synapses: Some Basic Questions

II. Aging of Autonomie Neurons: A Background

III. Age-Dependent Modifications of Axonal Transport

IV. The Chicken as an Animal Model of Aging

V. Acetylcholine Metabolism in Aging Avian Synapses

VI. Catecholamine Metabolism in Aging Avian Synapses

VII. Aging of Noradrenergic Neurons: A Comparison of CNS and PNS

VIII. Common Characteristics of Cholinergic and Adrenergic Terminals during Aging

IX. Variations in Cholinergic Receptors with Aging. CNS versus PNS

X. Development and Aging of Synapses: A Single Process?

XI. Conclusions: Toward a Pharmacology of Aging Synapses


Axonal Elongation in Peripheral and Central Nervous System Transplants

I. Introduction

II. Regeneration in the Peripheral and Central Nervous Systems

III. Transplants of Nonneuronal Cells

IV. Transplantation of Neurons and Target Tissues

V. Discussion



I. Introduction

II. Myelin

III. Animal Models of Immunologically Mediated Demyelination

IV. Tissue Culture Studies of Demyelination

V. Conclusions


CNS Hypomyelinated Mutant Mice: Morphological and Tissue Culture Studies

I. Introduction

II. Historical Background

III. The Common Clinical Syndrome

IV. Genetics and Morphology of Specific Mutations

V. Experimental Analysis: The Tissue Culture System


Section 3. Methodologies

Progress in Cerebral Micro-vascular Studies Related to the Function of the Blood-Brain Barrier

I. Introduction

II. Endothelial Cell Cultures

III. CerebralMicrovessels

IV. Conclusions


Isolation and Characterization of the Cells of the Cerebral Microvessels

I. Introduction

II. Isolation of Microvessels

III. Culture of Vessels and Derived Cells

IV. Studies on Cells Derived from Microvessels

V. Concluding Remarks


PCI2 Pheochromocytoma Cultures in Neurobiological Research

I. Introduction

II. Historical Background

III. The Classification of PC12 Cells

IV. Chromaffin Cell-like Properties of PC12 Cells

V. Responses to NGF

VI. The Developmental Significance of the PC12 Line

VII. Applications of PC12 Cells

VIII. Practical Aspects of the Growth and Maintenance of PC12 Cells

IX. Addendum




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© Academic Press 1982
28th January 1982
Academic Press
Hardcover ISBN:
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About the Editors

Sergey Fedoroff

Leif Hertz

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