This volume of Advances in Cancer Research begins with a review by M. Roussel of the key effectors of cytokine and growth factor signaling to the cell cycle block. P 53 and how it controls the cell cycle, genomic stability, and apoptosis are reviewed by M.R.A. Mowat. The third chapter, by T.S. Lewis and colleagues, discusses the effect of MAP kinase cascades as examples of signal transduction mechanisms in signaling pathways. In Chapter 4, Sozi et al. Review the frequent abnormalities found in the FHIT gene in a variety of cancer-derived cell lines. Volume 74 concludes with an overview by J.J. Hsuan and co-workers of the cellular functions of PtdlnsP2 and the regulation of its biosynthesis.
Graduate students and researchers in developmental, molecular, and cell biology as well as genetics, zoology, agriculture, and neuroscience.
Table of Contents
M.F. Roussel, Key Effectors of Signal Transduction and G1 Progression.
M.R.A. Mowat, p53 in Tumor Progression: Life, Death, and Everything.
T.S. Lewis, P.S. Shapiro, and N.G. Ahn, Signal Transduction through MAP Kinase Cascades.
G. Sozzi, K. Huebner, and C.M. Croce, FHIT in Human Cancer.
J.J. Hsuan, S. Minogue, and M. dos Santos, Phosphoinositide 4- and 5-Kinases and the Cellular Roles of Phosphatidylinositol 4,5-Bisphosphate.
@from:Praise for the Serial:
@qu:"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences."
@qu:"Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced."
@source:--JOURNAL OF MEDICINAL CHEMISTRY