Advances in Cancer Research - 1st Edition - ISBN: 9780120066643, 9780080562469

Advances in Cancer Research, Volume 64

1st Edition

Serial Volume Editors: George Vande Woude George Klein
eBook ISBN: 9780080562469
Imprint: Academic Press
Published Date: 7th November 1994
Page Count: 305
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Table of Contents

Interactions between Papillomavirus Proteins and tumor Suppressor Gene Products, K.H. Vousden. The Retinoblastoma Tumor Suppressor Protein, J.Y.J. Wange, E.S. Knudsen, and P.J. Welch. SH2 and SH3 Domains in Signal Transduction, T. Pawson. Activation of the Src Family of Tyrosine Kinases in Mammary Tumorigenesis, S.K. Muthuswamy and W.J. Muller. Oncogenic Properties of the Middle T Antigens of Polyomaviruses, F. Kiefer, S.A. Courtneidge, and E.F. Wagner. Selective Involvement of Protein Kinase C Isozymes in Differentiation and Neoplastic Transformation, J.Goodnight, H. Mischark, and J.F. Mushinski. FCg Receptors in Malignancies: Friends of Enemies? J. Gergely and G. Sármay. Dissecting Molecular Carcinogenesis: Development of Transgenic Mouse Models by Epidermal Gene Targeting, D.A. Greenhalgh and D.R. Roop. Index.


This volume contains reviews highlighting some of the most important achievements in understanding the molecular basis of cancer. Included are reviews on human papilloma virus and tumor suppressor gene products, the function of SH2 and SH3 domains in tyrosine kinase signal transduction, oncogene activation in mammary tumors, the phenotypes of polyoma middle T antigen in transgenic animals, and the role of protein kinase C and FCg receptors in neoplastic disease. Transgenic animal models for the study of molecular events in cancer are especially featured in these reviews.

Key Features

  • Highlights of Volume 64:
  • Interactions of papilloma virus proteins with tumor suppressors
  • Retinoblastoma tumor suppressor protein
  • SH2 and SH3 domains in tyrosing kinase signal transduction
  • Oncogene activation in mammary tumors
  • Polyomavirus middle T antigen phenotypes in transgenic animals
  • Protein kinase C and FCg receptors in neoplastic disease
  • Transgenic mouse models for molecular carcinogenesis


No. of pages:
© Academic Press 1994
Academic Press
eBook ISBN:


@qu:"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." @source:--AMERICAN SCIENTIST @qu:"Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." @source:--JOURNAL OF MEDICINAL CHEMISTRY @qu:"Oncologists as well as other researchers and clinicians employing interferon will find this survey of interest." @source:--BIOLOGICAL ABSTRACTS

Ratings and Reviews

About the Serial Volume Editors

George Vande Woude Serial Volume Editor

Affiliations and Expertise

Director, Van Andel Research Institute, Grand Rapids, MI, USA NCI-Frederick Cancer Research Facility Frederick, Maryland ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland

George Klein Serial Volume Editor

Affiliations and Expertise

Karolinska Insitutet, Stockholm, Sweden