Volume 68 of Advances in Cancer Research continues the tradition of publishing up-to-date reviews and "hot" topics in cancer research. This volume begins with a "Foundations in Cancer Research" article by Harald zur Hausen that reviews his years of research on the idea that cancer can be triggered by infection. The structure and function of the cytokine receptor superfamily and its association with leukemias are discussed in depth by James Ihle. Marcia Hall and Gordon Peters review the evidence indicating that genetic abnormalities hinder the function of certain cyclins and their inhibitors. The most widely studied protooncogene, c-myc, is reviewed by Marie Henriksson and Bernhard Lüscher; the chapter focuses on the function of c-myc as a transcription factor rather than on the effects of gene translocation and activation on malignancies. Ham Werner and Derek LeRoith present data on the role that insulin-like growth factors play on cell growth and regulation. In the final chapter, Olli-P. Kallioniemi and Tapio Visakorpi investigate the field of prostate cancer and, more importantly, the biological reason and natural history behind the growth of this cancer.


Researchers and students in basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, virology, and molecular biology.

Table of Contents

Foundations in Cancer Research: H. zur Hausen, Viruses in Human Tumors--Reminiscences and Perspectives: Epstein-Barr Virus DNA in Burkitt's Lymphomas and Nasopharyngeal Cancers. Papillomavirus Etiologyof Cancer of the Cervix. Papillomaviruses in Nonanogenital Cancers. Viruses as Tumor Initiators--Their Role as Inducers of Specific DNA Amplifications and as Mutagens. The Search for Other Tumorviruses. References. J.N. Ihle, Signaling by the Cytokine Receptor Superfamily in Normal and Transformed Hematopoietic Cells: Introduction. Structure of the Cytokine Receptor Superfamily. Leukemic Transformation by Structurally Altered Cytokine Receptors. Tyrosine Phosphorylation in Cytokine Receptor Function. Cytoplasmic Tyrosine Kinases Implicated in Specific Cytokine Responses. Janus, Kinases: A Unique Family of Cytoplasmic Protein Tyrosine Kinases: Association of Jaks with Cytokine Receptors and Activation Following Ligand Binding. Activation of ras Signaling Pathway by Cytokine Receptors. Cytokine-Induced Increases in Phosphatidylinositol (PI) 3-Kinase Activity. Cytokine-Induced Tyrosine Phosphorylation of Vav. Hematopoietic Cell Phosphatase: A Negative Growth Regulator. Syp Tyrosine Phosphatase: A Positive Growth Regulator. IRS-1 and 4PS: Signal Transducers Phosphorylated in Response to Cytokines. Stats: A Novel Family of Transcription Factors Identified in Interferon Signaling. Stats: A Common Theme in Cytokine Signaling. Mechanisms of Stat Recruitment to Cytokine Receptor Complexes. Concluding Remarks. References. M. Hall and G.


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@qu:"This classic and essential series presents critical overviews on select aspects of both cancer research and the basic underlying sciences." @source:--AMERICAN SCIENTIST @qu:"Excellent, highly informative, in-depth reviews... expertly written, up-to-date, and well-referenced." @source:--JOURNAL OF MEDICINAL CHEMISTRY