Advanced Free Radical Reactions for Organic Synthesis

1st Edition

Print ISBN: 9780444544711
eBook ISBN: 9780080524252
Imprint: Elsevier Science
Published Date: 14th January 2004
Page Count: 270
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Free radical reactions have become increasingly important and a very attractive tool in organic synthesis in the last two decades, due to their powerful, selective, specific, and mild reaction abilities. Advanced Free Radical Reactions for Organic Synthesis reviews information on all types of practical radical reactions, e.g. cyclizations, additions, hydrogen-atom abstractions, decarboxylation reactions. The book usefully provides experimental details for the most important reactions as well as numerous references to the original literature. By covering both the fundamentals and synthetic applications it is therefore suitable for both new and experienced researchers, chemists, biochemists, natural product chemists and graduate students. This title is the definitive guide to radical chemistry for all scientists.

Key Features

  • Introduces and reviews the use of radicals to perform synthetic transformations.
  • Practical details are provided for the most important methods.
  • Numerous references to the original literature.


for new and experienced researchers, chemists, biochemists, natural product chemists and graduate students.

Table of Contents

1. What are Free Radicals? General Aspects of Free Radicals. -Aspects of free radicals. -Types of free radicals. -Reaction style of radicals. -Orientation in radical additions. -Reactivity in radical additions. -Reaction patterns of radicals. -Generation of radicals. Familiar and Close Radicals in Our Lives. Stable Free Radicals. Physical and Chemical Characteristics of Free Radicals. -Orbital interactions between radicals and olefins. -Baldwin's rule. -Rate constants in radical reactions.

2. Functional Group Conversion Radical Coupling Reactions. Radical Reduction. Conversion to Hydroxy Group and Other Functional Groups.

3. Intramolecular Radical Cyclizations Cyclization to Small-Sized Rings. -Cyclization onto olefinic group and acetylenic group by sp3 carbon-centered radicals. -Cyclization onto Olefinic Group and Aromatic Group by sp2 Carbon-Centered Radicals. -Generation of sp carbon-centered radicals. -Cyclization onto carbonyl group by sp3 or sp2 carbon-centered radicals and other related cyclizations. Cyclization to Medium-Sized and Large-Sized Rings. Ring Expansions. Cyclization to Spiro Skeleton. Tandem Cyclization to Polycyclic Rings.

4. Intermolecular Radical Addition Reactions Addition to Olefins. -Reductive conditions. -Oxidative conditions. -Photochemical conditions. -Addition-elimination reactions. Allylation Reactions. Additi


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@qu: The author has succeeded in presenting many facets of this very interesting area of chemistry in a highly engaging manner. As a result, anyone who wishes to familiarize themselves with the field of radical chemistry should take the time to look through "Advanced Free Radical Reactions for Organic Synthesis". @source: ORGANIC CHEMISTRY, 2005