Accurate Results in the Clinical Laboratory

Accurate Results in the Clinical Laboratory

A Guide to Error Detection and Correction

2nd Edition - July 20, 2019
This is the Latest Edition
  • Editors: Amitava Dasgupta, Jorge Sepulveda
  • eBook ISBN: 9780128137772
  • Hardcover ISBN: 9780128137765

Purchase options

Purchase options
DRM-free (Mobi, EPub, PDF)
Available
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

Accurate Results in the Clinical Laboratory: A Guide to Error Detection and Correction, Second Edition, provides a comprehensive review of the factors leading to errors in all areas of clinical laboratory testing. This trusted guide addresses interference issues in all laboratory tests, including patient epigenetics, processes of specimen collection, enzymes and biomarkers. Clinicians and laboratory scientists will both benefit from this reference that applies discussions to both accurate specimen analysis and optimal patient care. Hence, this is the perfect reference for clinical laboratorians, from trainees, to experienced pathologists and directors.

Key Features

  • Provides comprehensive coverage across endocrine, oncology, hematology, immunohistochemistry, immunology, serology, microbiology, and molecular testing
  • Includes new case studies that highlight clinical relevance and errors to avoid
  • Highlights the best titles published within a variety of medical specialties
  • Reviewed by medical librarians and content specialists, with key selections compiled in their annual list

Readership

Pathologists, clinical chemists, and toxicologists; practicing clinicians, fellows and residents in pathology, internal medicine, emergency medicine and family practice

Table of Contents

  • Section I: Sources of errors in clinical laboratories: An overview
    1. Variation, errors, and quality in the clinical laboratory
    2. Errors in patient preparation, specimen collection, anticoagulant and preservative use: how to avoid such pre-analytical errors
    3. Sample processing and specimen misidentification issues: major sources of pre-analytical errors
    4. Effect of patient-related factors on clinical laboratory test results
    5. Interferences of hemolysis, lipemia and high bilirubin on laboratory tests
    6. Immunoassay design
    7. Overview of other sources of interferences in immunoassays: prozone effect and interferences from heterophilic antibodies and autoantibodies
    8. Biotin interference in clinical laboratory tests: sporadic problem or a serious clinical issue?

    Section II: Sources of errors in clinical chemistry laboratory
    9. Challenges in routine clinical chemistry testing analysis of small molecules
    10. Challenges in routine clinical chemistry analysis: proteins and enzymes
    11. Challenges in endocrinology testing
    12. Pitfalls in testing for common tumor markers

    Section III: Sources of errors in therapeutic drug monitoring and toxicology
    13. Issues of interferences in therapeutic drug monitoring
    14. Limitations of immunoassays for screening of drugs of abuse in urine: issues of false positive and false negative results
    15. Challenges in confirmation testing for drugs of abuse
    16. Issues of false negative results in toxicology: difficult in detecting certain drugs and issues with detection of synthetic cathinone (bath salts), synthetic cannabinoids (spice), and other new psychoactive substances
    17. Ethanol determination using automated analyzers: limitations and pitfalls

    Section IV: Herbal medicines and laboratory testings
    18. Effects of herbal supplements on clinical laboratory test results

    Section V: Sources of errors in immunology laboratory
    19. Critical issues in hemoglobinopathy detection and serology testing for HIV and hepatitis infections
    20. Sources of errors in immunology and serology testing

    Section VI: Sources of errors in molecular, genetic and related testings
    21. Sources of error in molecular diagnostic analyses
    22. Molecular testing for targeted therapies and pharmacogenomics
    23. Challenges and sources of inaccuracy in biochemical genetics testing

    Section VII: Sources of errors in microbiology testings
    24. Sources of pre-analytical, analytical and post-analytical errors in the microbiology laboratory

    Section VIII: Sources of errors in hematology and coagulation testings
    25. Sources of errors in hematology testing
    26. Sources of errors in coagulation testing
    27. Sources of errors in flow cytometry

    Section IX: Sources of errors in transfusion medicine
    28. Interferences in blood bank testing
    29. Errors and adverse effects of blood transfusion
    30. Methodological issues in point of care testing devices
    31. Special concern: sources of inaccuracy in breath alcohol analysis

Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: July 20, 2019
  • Imprint: Elsevier
  • eBook ISBN: 9780128137772
  • Hardcover ISBN: 9780128137765
  • About the Editors

    Amitava Dasgupta

    Amitava Dasgupta
    Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.

    Affiliations and Expertise

    Professor, Pathology and Laboratory Medicine, McGovern Medical School, The University of Texas, Houston, TX, USA

    Jorge Sepulveda

    Jorge Sepulveda received his M.D. from the University of Lisbon, Portugal, and his residency training in Laboratory Medicine and Ph.D. degree in Cell and Molecular Biology from Baylor College of Medicine, Houston, Texas. He is board certified by the American Board of Pathology in Clinical Pathology and Transfusion Medicine. He has published over 35 research articles, review papers and book chapters, and serves as Associate Editor for the Archives of Pathology and Laboratory Medicine. Dr. Sepulveda has broad experience in laboratory medicine as medical director of various clinical laboratories, including at the Houston and Philadelphia Veterans Affairs Medical Centers and at the University of Pittsburgh Presbyterian and Shadyside Hospitals, and currently serves as Associate Medical Director of the Clinical Laboratories at the Columbia University Medical Center Campus of New York-Presbyterian Hospital.

    Affiliations and Expertise

    Associate Professor and Associate Director of Laboratory Medicine, Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY, USA