A New Look at Mechanisms in Bioenergetics

1st Edition - January 1, 1976
Author: Efraim Racker
Language: English
eBook ISBN:
9 7 8 - 1 - 4 8 3 2 - 6 8 4 2 - 2

A New Look at Mechanisms in Bioenergetics is a collection of lectures given at the Robbins Lectures at Pomona College in April, 1973. The lectures contained in the book are based… Read more

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A New Look at Mechanisms in Bioenergetics is a collection of lectures given at the Robbins Lectures at Pomona College in April, 1973. The lectures contained in the book are based on laboratory works on oxidative phosphorylation. The text starts by defining oxidative phosphorylation, and after which, began a series of discussions on the biochemical approach to the problem of photophosphorylation; functions and structure of membranes and the mechanism of phosphorylation coupled to electron transport; and the basic principle of the control that governs both glycolysis and oxidation. Biochemists and biologists will find the book interesting and amusing.

ContentsPrefaceAbbreviationsLecture 1 Troubles Are Good for You How It All Started What Is Oxidative Phosphorylation? How Do We Measure Oxidative Phosphorylation? First Approaches to the Resolution of the Membrane Allotopic Properties of F1 Electron Microscopy Isolation of Resolved Particles Reconstitution of Oxidative Phosphorylation Lecture 2 Photophosphorylation On the Origin of Life Electron Pathway in Photophosphorylation Further Similarities with Mitochondria Resolution of a Coupling Factor Proton Movements in Chloroplasts Asymmetric Assembly of the Chloroplast Membrane Reversal of Photophosphorylation Lecture 3 Functions and Structure of Membranes and the Mechanism of Phosphorylation Coupled to Electron Transport General Comments Function and Structure of Membranes Mechanism of Phosphorylation Coupled to Electron Transport Experimental Approaches Lecture 4 The Coupling Device Partial Reactions and Components of the Coupling Device The ATP-Driven Proton Pump Lecture 5 The Oxidation Chain and the Topography of the Inner Mitochondrial Membrane Analysis of the Oxidation Chain Isolation of Complexes and Individual Catalysts The Three Segments of the Oxidation Chain The Topography of the Oxidation Chain Lecture 6 Resolution and Reconstitution of Oxidative Phosphorylation General Comments Reconstitutions of Mitochondrial and Chloroplast Membrane Functions Reconstitution of the Proton Pump of Halobacterium halobium and of Rhodopsin-Catalyzed Photophosphorylation Lecture 7 Reconstitution and Mechanism of Action of Ion Pumps General Comments Reconstitution of Ion Pumps What Can We Learn from Resolution and Reconstitution Experiments? Lecture 8 Control of Energy Metabolism Oxidation Control The Pasteur Effect The Competition Mechanism High Aerobic Glycolysis in Tumor (The Warburg Effect) ATPases in Tumor Cells Repair of Ion Pumps in Tumor CellsBibliographyIndex