A New Look at Mechanisms In Bioenergetics

A New Look at Mechanisms In Bioenergetics

1st Edition - January 1, 1976

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  • Author: Efraim Racker
  • eBook ISBN: 9780323160117

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Description

A New Look at Mechanisms in Bioenergetics features eight lectures based on the Robbins Lectures given at Pomona College in April 1973. These lectures are based mainly on the author's own laboratory work and are intended for students of biology and biochemistry who want to devote their lives to research. Lecture 1 presents some of the general lessons learned from research in the field of bioenergetics. It also discusses methods for measuring oxidative phosphorylation and the resolution of soluble multienzyme systems. Lecture 2 explains the biochemical approach to the problem of photophosphorylation. Lecture 3 considers the intersection of oxidative phosphorylation and membranology. Lecture 4 discusses the coupling device and its partial reactions. Lecture 5 focuses on the oxidation chain in mitochondria. Lecture 6 discusses the resolution and reconstitution of oxidative phosphorylation. Lecture 7 examines the reconstitution of ion pumps. Finally, Lecture 8 covers oxidation control in glycolysis; the high aerobic glycolysis of tumor cells; ATPases in tumor cells; and the repair of ion pumps in tumor cells.

Table of Contents


  • Preface

    Abbreviations

    Lecture 1 Troubles Are Good for You

    How It All Started

    What Is Oxidative Phosphorylation?

    How Do We Measure Oxidative Phosphorylation?

    First Approaches to the Resolution of the Membrane

    Alio topic Properties of F1

    Electron Microscopy

    Isolation of Resolved Particles

    Reconstitution of Oxidative Phosphorylation

    Lecture 2 Photophosphorylation

    On the Origin of Life

    Electron Pathway in Photophosphorylation

    Further Similarities with Mitochondria

    Resolution of a Coupling Factor

    Proton Movements in Chloroplasts

    Asymmetric Assembly of the Chloroplast Membrane

    Reversal of Photophosphorylation

    Lecture 3 Functions and Structure of Membranes and the Mechanism of Phosphorylation Coupled to Electron Transport

    General Comments

    Function and Structure of Membranes

    Mechanism of Phosphorylation Coupled to Electron Transport

    Experimental Approaches

    Lecture 4 The Coupling Device

    Partial Reactions and Components of the Coupling Device

    The ATP-Driven Proton Pump

    Lecture 5 The Oxidation Chain and the Topography of the Inner Mitochondrial Membrane

    Analysis of the Oxidation Chain

    Isolation of Complexes and Individual Catalysts

    The Three Segments of the Oxidation Chain

    The Topography of the Oxidation Chain

    Lecture 6 Resolution and Reconstitution of Oxidative Phosphorylation

    General Comments

    Reconstitutions of Mitochondrial and Chloroplast Membrane Functions

    Reconstitution of the Proton Pump of Halobacterium halobium and of Rhodopsin-Catalyzed Photophosphorylation

    Lecture 7 Reconstitution and Mechanism of Action of Ion Pumps

    General Comments

    Reconstitution of Ion Pumps

    What Can We Learn from Resolution and Reconstitution Experiments?

    Lecture 8 Control of Energy Metabolism

    Oxidation Control

    The Pasteur Effect

    The Competition Mechanism

    High Aerobic Glycolysis in Tumor Cells (The Warburg Effect)

    ATPases in Tumor Cells

    Repair of Ion Pumps in Tumor Cells

    Bibliography

    Index




Product details

  • No. of pages: 212
  • Language: English
  • Copyright: © Academic Press 1976
  • Published: January 1, 1976
  • Imprint: Academic Press
  • eBook ISBN: 9780323160117

About the Author

Efraim Racker

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