A New Look at Mechanisms In Bioenergetics

1st Edition - January 1, 1976
Author: Efraim Racker
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 6 0 1 1 - 7

A New Look at Mechanisms in Bioenergetics features eight lectures based on the Robbins Lectures given at Pomona College in April 1973. These lectures are based mainly on the… Read more

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A New Look at Mechanisms in Bioenergetics features eight lectures based on the Robbins Lectures given at Pomona College in April 1973. These lectures are based mainly on the author's own laboratory work and are intended for students of biology and biochemistry who want to devote their lives to research. Lecture 1 presents some of the general lessons learned from research in the field of bioenergetics. It also discusses methods for measuring oxidative phosphorylation and the resolution of soluble multienzyme systems. Lecture 2 explains the biochemical approach to the problem of photophosphorylation. Lecture 3 considers the intersection of oxidative phosphorylation and membranology. Lecture 4 discusses the coupling device and its partial reactions. Lecture 5 focuses on the oxidation chain in mitochondria. Lecture 6 discusses the resolution and reconstitution of oxidative phosphorylation. Lecture 7 examines the reconstitution of ion pumps. Finally, Lecture 8 covers oxidation control in glycolysis; the high aerobic glycolysis of tumor cells; ATPases in tumor cells; and the repair of ion pumps in tumor cells.

PrefaceAbbreviationsLecture 1 Troubles Are Good for You How It All Started What Is Oxidative Phosphorylation? How Do We Measure Oxidative Phosphorylation? First Approaches to the Resolution of the Membrane Alio topic Properties of F1 Electron Microscopy Isolation of Resolved Particles Reconstitution of Oxidative PhosphorylationLecture 2 Photophosphorylation On the Origin of Life Electron Pathway in Photophosphorylation Further Similarities with Mitochondria Resolution of a Coupling Factor Proton Movements in Chloroplasts Asymmetric Assembly of the Chloroplast Membrane Reversal of PhotophosphorylationLecture 3 Functions and Structure of Membranes and the Mechanism of Phosphorylation Coupled to Electron Transport General Comments Function and Structure of Membranes Mechanism of Phosphorylation Coupled to Electron Transport Experimental ApproachesLecture 4 The Coupling Device Partial Reactions and Components of the Coupling Device The ATP-Driven Proton PumpLecture 5 The Oxidation Chain and the Topography of the Inner Mitochondrial Membrane Analysis of the Oxidation Chain Isolation of Complexes and Individual Catalysts The Three Segments of the Oxidation Chain The Topography of the Oxidation ChainLecture 6 Resolution and Reconstitution of Oxidative Phosphorylation General Comments Reconstitutions of Mitochondrial and Chloroplast Membrane Functions Reconstitution of the Proton Pump of Halobacterium halobium and of Rhodopsin-Catalyzed PhotophosphorylationLecture 7 Reconstitution and Mechanism of Action of Ion Pumps General Comments Reconstitution of Ion Pumps What Can We Learn from Resolution and Reconstitution Experiments?Lecture 8 Control of Energy Metabolism Oxidation Control The Pasteur Effect The Competition Mechanism High Aerobic Glycolysis in Tumor Cells (The Warburg Effect) ATPases in Tumor Cells Repair of Ion Pumps in Tumor CellsBibliographyIndex