3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine
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3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine, Second Edition provides an in-depth introduction to bioprinting and nanotechnology and their industrial applications. Sections cover 4D Printing Smart Multi-responsive Structure, Cells for Bioprinting, 4D Printing Biomaterials, 3D/4D printing functional biomedical devices, 3D Printing for Cardiac and Heart Regeneration, Integrating 3D printing with Ultrasound for Musculoskeletal Regeneration, 3D Printing for Liver Regeneration, 3D Printing for Cancer Studies, 4D Printing Soft Bio-robots, Clinical Translation and Future Directions. The book's team of expert contributors have pooled their expertise in order to provide a summary of the suitability, sustainability and limitations of each technique for each specific application. The increasing availability and decreasing costs of nanotechnologies and 3D printing technologies are driving their use to meet medical needs. This book provides an overview of these technologies and their integration.
Key Features
- Includes clinical applications, regulatory hurdles, and a risk-benefit analysis of each technology
- Assists readers in selecting the best materials and how to identify the right parameters for printing
- Includes the advantages of integrating 3D printing and nanotechnology in order to improve the safety of nano-scale materials for biomedical applications
Readership
Engineers, academics, students, clinicians and professionals in biomedical engineering, medical devices, tissue engineering, and biomaterials
Table of Contents
- Cover image
- Title page
- Table of Contents
- Copyright
- List of contributors
- Preface
- Part I: Principles
- Chapter 1. Nanotechnology: A Toolkit for Cell Behavior
- Abstract
- 1.1 Introduction
- 1.2 Nanobiomaterials for Tissue Regeneration
- 1.3 3D Nano/Microfabrication Technology for Tissue Regeneration
- 1.4 Conclusion and Future Directions
- Acknowledgments
- Questions
- References
- Chapter 2. Bioprinting of Biomimetic Tissue Models for Disease Modeling and Drug Screening
- Abstract
- Graphical Abstract
- 2.1 Introduction
- 2.2 Current 3D Bioprinting Approaches to Build Biomimetic Tissue Models
- 2.3 Drug Screening and Disease Modeling Applications in Various Organs
- 2.4 Challenges and Future Outlook
- Acknowledgments
- Declaration of Interests
- References
- Chapter 3. 3D Bioprinting Techniques
- Abstract
- 3.1 Introduction
- 3.2 Definition and Principles of 3D Bioprinting
- 3.3 3D Bioprinting Technologies
- 3.4 Challenges and Future Development of 3D Bioprinting
- 3.5 Conclusion
- References
- Chapter 4. The Power of CAD/CAM Laser Bioprinting at the Single-Cell Level: Evolution of Printing
- Abstract
- 4.1 Introduction
- 4.2 Basics of Laser-Assisted Printing: Overview of Systems and Critical Ancillary Materials
- 4.3 Matrix-Assisted Pulsed-Laser Evaporation Direct-Write Mechanistics
- 4.4 Postprocessing Cell Viability and Function
- 4.5 Case Studies and Applications Illustrating the Importance of Single-Cell Deposition
- 4.6 Conclusion
- References
- Chapter 5. Laser Direct-Write Bioprinting: A Powerful Tool for Engineering Cellular Microenvironments
- Abstract
- 5.1 Introduction
- 5.2 Materials in Laser Direct-Write
- 5.3 Laser Direct-Write Applications in 2D
- 5.4 Laser Direct-Write Applications in 3D
- 5.5 Conclusions and Future Directions
- Acknowledgments
- Questions
- References
- Chapter 6. Bioink Printability Methodologies for Cell-Based Extrusion Bioprinting
- Abstract
- 6.1 Introduction
- 6.2 Definition of Printability
- 6.3 Relationships Between Printing Outcomes and Rheological Properties
- 6.4 Relationships Between Printing Outcomes and Process Parameters
- 6.5 Models for Printability
- 6.6 Current Limitations
- 6.7 Conclusion
- Acknowledgments
- Questions
- References
- Chapter 7. Hydrogels for Bioprinting
- Abstract
- 7.1 Hydrogels in Bioprinting
- 7.2 Considerations for Using Hydrogel in Bioprinting
- 7.3 Strategies Used in Hydrogel-Based Bioprinting
- 7.4 Perspective and Outlook
- References
- Chapter 8. 4D Printing: 3D Printing of Responsive and Programmable Materials
- Abstract
- 8.1 Introduction
- 8.2 Responsive and Programmable Materials for 4D Printing
- 8.3 Realization of 4D Printing
- 8.4 Applications of 4D Printing
- 8.5 Conclusion and Prospective
- Questions
- References
- Part II: Applications: Nanotechnology and 3D Bioprinting for Tissue/Organ Regeneration
- Chapter 9. Blood Vessel Regeneration
- Abstract
- 9.1 Introduction
- 9.2 Cell-Free Scaffolds
- 9.3 Cell-Based Scaffolds
- 9.4 Comparison of the Technologies
- 9.5 Future Directions
- Acknowledgments
- References
- Chapter 10. 3D Printing and Patterning Vasculature in Engineered Tissues
- Abstract
- 10.1 Introduction
- References
- Chapter 11. Craniofacial and Dental Tissue
- Abstract
- 11.1 Introduction
- 11.2 Clinical Need for Craniofacial and Dental Regenerative Medicine
- 11.3 Craniofacial and Dental Regenerative Medicine Research
- 11.4 Bone Tissue Engineering Strategies
- 11.5 Conclusions
- Acknowledgment
- References
- Chapter 12. 3D Printing for Craniofacial Bone Regeneration
- Abstract
- 12.1 Introduction
- 12.2 Anatomy and Mechanics of Craniofacial Bone
- 12.3 Materials for Craniofacial Scaffold
- 12.4 3D-Printing Techniques for Craniofacial Scaffold
- 12.5 Enhancing the Regenerative Capability of Biomaterials in Craniofacial Bone Regeneration
- 12.6 Case Studies: Application of Porous Scaffold Design for Clinical Applications
- 12.7 Conclusion
- References
- Chapter 13. Additive Manufacturing for Bone Load Bearing Applications
- Abstract
- 13.1 Need for Bone Substitutes
- 13.2 Compositional, Structural and Mechanical Properties of Bone
- 13.3 Difficulties in Achieving an Ideal Bone Substitute
- 13.4 Metallic Bone Substitutes
- 13.5 Bioceramic Bone Substitutes
- 13.6 Nanocomposite Bone Substitutes
- 13.7 Conclusions
- References
- Chapter 14. 3D Printing of Cartilage and Subchondral Bone
- Abstract
- 14.1 Background
- 14.2 Applications of 3D Printing
- 14.3 Major Challenges and Pitfalls
- 14.4 Future Directions
- Acknowledgments
- References
- Chapter 15. Bioprinting for Skin
- Abstract
- 15.1 Skin, Skin Substitutes, Possible Applications for Printed Skin
- 15.2 Skin Substitutes, Applications for Printed Skin
- 15.3 Skin Substitutes Generated by Bioprinting
- 15.4 Discussion of the Different Bioprinting Techniques and Clinical Applicability
- 15.5 Conclusion
- Acknowledgments
- References
- Chapter 16. Nanotechnology and 3D/4D Bioprinting for Neural Tissue Regeneration
- Abstract
- 16.1 Introduction
- 16.2 Nanotechnology for Neural Tissue Regeneration
- 16.3 3D/4D Bioprinting for Neural Tissue Regeneration
- 16.4 Conclusion and Future Directions
- Acknowledgments
- Questions
- References
- Chapter 17. 3D Bioprinting for Liver Regeneration
- Abstract
- 17.1 Introduction
- 17.2 Structural and Functional Complexity of the Liver
- 17.3 Liver Diseases
- 17.4 Regeneration of the Liver
- 17.5 Liver Tissue Engineering and 3D Bioprinting
- 17.6 3D-Bioprinted Liver Tissues
- 17.7 Challenges and Future Perspectives
- Acknowledgments
- Questions
- References
- Chapter 18. Organ Printing
- Abstract
- 18.1 Introduction
- References
- Chapter 19. 3D Bioprinting, Nanotechnology, and Intellectual Property
- Abstract
- 19.1 Introduction
- 19.2 Why is Intellectual Property Important?
- 19.3 Types of Intellectual Property
- 19.4 Where Does Intellectual Property Law Originate?
- 19.5 What Aspects of 3D Bioprinting and Nanotechnology are Protectable?
- 19.6 Intellectual Property Protection Limitations for Engineered Tissue
- 19.7 Ethical Considerations of Engineered Tissue Intellectual Property
- 19.8 Intellectual Property Infringement
- 19.9 Conclusion
- Questions
- Answers to Questions
- Index
Product details
- No. of pages: 562
- Language: English
- Copyright: © Academic Press 2022
- Published: February 18, 2022
- Imprint: Academic Press
- eBook ISBN: 9780128245538
- Hardcover ISBN: 9780128245521
About the Editors
Lijie Zhang
Dr. Zhang is the Director of the Bioengineering Laboratory for Nanomedicine and Tissue Engineering. Her research interests include 3D/4D bioprinting, nanotechnology, complex tissue engineering, cancer metastasis model, and soft bio-robotics. She is a Fellow of the American Institute for Medical and Biological Engineering and has received many prestigious awards including NIH Director’s New Innovator Award. Dr. Zhang is currently the Editor-in-Chief of Biomedical Engineering Advances and Associate Editors for several high-impact international journals.
Affiliations and Expertise
Professor and Associate Dean for Research, School of Engineering and Applied Science, The George Washington University, USA
Kam Leong
Dr. Leong is the Director of Nanotherapeutics and Stem Cell Engineering Laboratory. His research focuses on the development of innovative biomaterials for drug and delivery, nonviral gene editing, and regenerative medicine. He is a member of the National Academy of Engineering, National Academy of Medicine, and National Academy of Inventors, and the Editor-in-Chief of Biomaterials.
Affiliations and Expertise
Samuel Y. Sheng Professor, Department of Biomedical Engineering, Columbia University
John Fisher
Dr. Fisher is the Director of the Tissue Engineering and Biomaterials Laboratory and investigates biomaterials, stem cells, and bioreactors for the regeneration of lost tissues, particularly bone, cartilage, vasculature, and skeletal muscle. In 2012 Dr. Fisher was elected Fellow of the American Institute for Medical and Biological Engineering. Dr. Fisher is currently the co-Editor-in-Chief of the journal Tissue Engineering.
Affiliations and Expertise
Fischell Family Distinguished Professor and Chair, Fischell Department of Bioengineering, University of Maryland
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