
100 Years of Human Chorionic Gonadotropin
Reviews and New Perspectives
Description
Key Features
- Provides updated information on a complex and changing subject in five sections
- Reviews historical perspectives and developments over the last 100 years
- Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer
- Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests
- Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment
- Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer.
- Includes chapters on the development and use of hCG vaccines
- Includes a section on hCG and in subunits in cancer
Readership
Researchers in reproductive medicine and endocrinology; Oncology
Table of Contents
Forward- 100 Years of hCG
Introduction - 100 Years of hCG - Meet the Editors and the Authors
Section 1 - Genes and Structure
Chapter 1.1 - Isolating C5 and B152 - Anecdote
Chapter 1.2 - Evolutionary, structural and physiological differences between hCG and LH
Chapter 1.3 - hCG and Human Evolution - The Master Molecule
Chapter 1.4 - Human Chorionic Gonadotropin: Different Origins, Glycoforms and Functions during Pregnancy
Chapter 1.5 - Molecular Modelling of hCG: influence of glycosylation and nicking on molecular folding and epitope recognition
Chapter 1.6 - Why is hCG Glycosylated
Section 2 - Detection and Quantitation
Chapter 2.1 - Detecting hCG that’s not there - Annecdote
Chapter 2.2 - Quantification of hCG by MALDI ToF Mass Spectrometry
Chapter 2.3 - Pregnancy failures and false positive hCG tests
Chapter 2.4 - Home Pregnancy Tests
Chapter 2.5 - Human Chorionic Gonadotropin determination using mass spectrometry
Chapter 2.6 - Beta core fragment as a standard quality control in MALDI
Section 3 - Pregnancy and Fertility
Chapter 3.1 - hCG as an LH analogue - Anecdote
Chapter 3.2 - The role of hCG in endometrial receptivity and embryo implantation
Chapter 3.3 - Qualitative Analysis of hCG Variants and Glycoforms in Urine
Chapter 3.4 - Phenotypic characterization of a transgenic mouse model overproducing hCG
Chapter 3.5 - The Role of Human Chorionic Gonadotropin in Reproductive Medicine
Chapter 3.6 - Pregnancy and hCG
Chapter 3.7 - My Journey with Human Chorionic Gonadotropin: development of a Unique Vaccine for control of fertility
Chapter 3.8 - Evaluation of Delivery Vectors for Active Immunisation with Synthetic Peptides of hCG as a Fertility Control Method
Section 4 - Cancer and Therapy
Chapter 4.1 - How hCG and a failed experiment changed my life - Anecdote
Chapter 4.2 - Human chorionic gonadotropin in cancer – where are we?
Chapter 4.3 - LH/hCG-receptor independent activities of hCG and hCGβ
Chapter 4.4 - The Role of the Free Beta Subunit of Human Chorionic Gonadotropin in Human Malignancy
Chapter 4.5 - hCG and Gestational Trophoblastic Diseases - Hydatidiform Mole and Choriocarcinoma
Chapter 4.6 - Immunotherapy of Advanced Stage, Invariably Drug Resistant Cancer Expressing ectopically hCG
Chapter 4.7 – A Potential Cure for Cancer
Section 5 - Conclusion
Chapter 5.1 - Where has hCG research been? What is hCG research doing? Which direction will it go in the future?
Product details
- No. of pages: 358
- Language: English
- Copyright: © Elsevier 2020
- Published: February 7, 2020
- Imprint: Elsevier
- Paperback ISBN: 9780128200506
- eBook ISBN: 9780128216095
About the Editors
Laurence Cole
Affiliations and Expertise
Stephen Butler
Affiliations and Expertise
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