Books in Life sciences

51-60 of 15097 results in All results

Vagus Nerve Stimulation

1st Edition
November 1, 2024
Peter Staats + 3 more
English
Hardback
9 7 8 - 0 - 1 2 - 8 1 6 9 9 6 - 4
eBook
9 7 8 - 0 - 1 2 - 8 1 6 9 9 7 - 1

The vagus nerve is one of the most important, yet most under-appreciated structures of the human body. It is the tenth cranial nerve innervating many of the visceral structures of the human body. It has been called the “wandering” nerve, given its ubiquitous and meandering course throughout the body. The major branch of the parasympathetic nervous system, it optimizes the body’s state of rest, relaxation and recovery and is necessary to optimize health. It is a counterbalance to the sympathetic nervous system, which regulates the body’s fight or flight response. Containing over 160,000 fibers, it has both afferent and efferent branches, providing information to the brain on the status of the body’s organs. The brain then sends signals back down the vagus nerve to optimize bodily functions. Vagus nerve stimulation is a new frontier in medicine, tapping into the body’s intrinsic capability to optimize an organ’s function, control systemic inflammation and modify diseases without drugs. The use of non-implanted vagus nerve stimulators has made it possible to move neuromodulation up the treatment continuum, and has facilitated access for clinical evaluation and treatment. Scientists now have the ability to translate the basic science into clinical practice without the need for surgical intervention. Vagus Nerve Stimulation serves as a compendium of current knowledge about stimulating the vagus nerve in many different disease states. Chapters include applications to neurologic conditions, psychiatric conditions, inflammatory conditions, metabolic disease, reperfusion injuries, long covid, cardiac disease and even optimizing performance in healthy individuals.

Site Specific and Global Epigenomic Editing

1st Edition
Volume 33
November 1, 2024
Feng C Zhou + 1 more
English
Paperback
9 7 8 - 0 - 1 2 - 8 1 9 3 9 8 - 3
eBook
9 7 8 - 0 - 1 2 - 8 1 9 3 9 9 - 0

Site Specific and Global Epigenomic Editing: Principles and Applications, Volume 33 highlights the expanding role that epigenetics plays in pathogenesis, the full range of sites for possible epigenetic modification, and the potential to target these sites to modulate disease progression. The book answers key questions, including which of the hundreds of epigenomic marks and features are relevant, and which are likely to serve a role in regulating gene expression, cell behavior and phenotypic outcomes. This volume is the first to provide a thorough, conceptual introduction to epigenetic regulation and a thorough accounting of sites for possible epigenetic edits and disease modulation. Included protocols and applied case studies examine early disease targets and likely pathways of therapeutic significance while also outlining common challenges in the field. The book addresses its topic in a comprehensive, but accessible manner, highlighting practical tools and burning questions remaining in the field to enable fresh research.

Early Detection in Alzheimer's Disease

1st Edition
November 1, 2024
Dennis Chan
English
Paperback
9 7 8 - 0 - 1 2 - 8 2 2 2 4 0 - 9
eBook
9 7 8 - 0 - 1 2 - 8 2 2 2 4 1 - 6

Early Detection of Alzheimer’s Disease: Biological and Technological Advances aims to introduce to a wide audience the high global priority problem of detecting AD prior to dementia onset. According to the Alzheimer’s Association, 5.8 million Americans are living with Alzheimer’s and care costs will cost the nation approximately $290 billion (2019 Alzheimer’s Disease Facts and Figures). With the failure of recent AD drug trials, many hypothesize that by the time symptoms appear, it is too late to be treated. Early detection can offer benefits such as more choice of medications, ability to participate in clinical trials, more time for family and for care planning. This book outlines potential solutions to the above problem using opportunities arising from the technology revolution, advances in neuroscience, and molecular biology. Most importantly, it discusses a paradigm shift from a reactive to a proactive diagnostic approach, aiming to detect disease before occurrence of symptoms. Topics covered include the use of sensing technologies (e.g. smartphones, smartwatches, Internet of Things) to detect early disease-related changes, the application of data science (machine learning/AI) to extract otherwise invisible disease features from these datasets and the potential to personalize diagnosis based on tracking changes in individual behaviours. Advances in blood-based biomarkers, brain imaging, and the potential for early diagnosis to aid interventions (lifestyle, dietary, pharmacological) to delay future development of dementia are also discussed.

Cardiac Sarcoidosis

1st Edition
November 1, 2024
Robert Phillip Baughman + 2 more
English
Paperback
9 7 8 - 0 - 1 2 - 8 2 2 3 3 2 - 1
eBook
9 7 8 - 0 - 1 2 - 8 2 2 3 3 3 - 8

In the past 5 years, there has been a tremendous increase in interest regarding diagnosis and management the cardiac involvement in sarcoidosis. This includes new imaging techniques, new evidence-based guidelines regarding diagnosis and treatment, as well as results of registries providing information regarding the outcome of disease. With this new information, the diagnosis and treatment of cardiac sarcoidosis has become better served. Many centres are now developing multi-disciplinary clinics and conferences to evaluate and treat these patients. These clinics highlight the problem that many different specialities are involved in the care of these patients. A book focusing on the different aspects of the disease will give a reference source for these efforts.Cardiac Sarcoidosis: A Multi-discipline Approach focuses on an important aspect of sarcoidosis: cardiac involvement. From pathology to diagnosis and screening of the disease through treatment options, the book comprehensively reviews known knowledge and explores emerging topics in the field, accompanied by illustrative cases and evidence-based recommendations in outlining the best disease management practices. The book is written by international experts in the field and serves as an essential reference for both clinicians and researchers on cardiac sarcoidosis.

Pathology of Laboratory Swine

1st Edition
November 1, 2024
Kris Helke + 3 more
English
Paperback
9 7 8 - 0 - 1 2 - 8 2 3 1 1 6 - 6
eBook
9 7 8 - 0 - 1 2 - 8 2 3 1 2 0 - 3

Pathology of Laboratory Swine is a comprehensive text describing the spontaneous pathology seen in common laboratory pig strains. As the first book collating information on all organ systems in these strains, this resource will serve as a “go to” text for all pathologists working on laboratory pigs in safety assessment studies and for veterinary pathologists who need a diagnostic tool to rule out spontaneous, non-clinical disease pathology when assigning cause of death to these animals which are also kept as domestic pets.

Balancing a Sauropod

1st Edition
November 1, 2024
Brant E Isakson
English
Paperback
9 7 8 - 0 - 1 2 - 8 2 3 3 0 3 - 0
eBook
9 7 8 - 0 - 1 2 - 8 2 3 4 1 9 - 8

Balancing a Sauropod: The Physiology of a Dinosaur provides a sound physiological underpinning for how they may have lived 100 million years ago. The book's topics focus on major organ systems and apply it to potential sauropod physiology. Less emphasis is given to the skeletal system, as that has been discussed extensively in other literature. Each organ system is discussed in terms of function and current understanding of how they work in a comparative environment. This resource is written at a technical level to both inform the lay reader and provide a sound argument to scientists in the field.Sauropods were the largest land animal to ever walk the earth with an incredible distance form heart to brain, begging the question, how did they maintain blood flow in their brain? Also, the climate sauropods lived in was hypoxic compared to what we live in now, so how did the dinosaurs breathe in the hypoxic Jurassic era? These questions and others expand to multiple fascinating questions the book will dissect in order of organ systems.

Insect Anatomy

1st Edition
November 1, 2024
Bernard Moussian
English
Paperback
9 7 8 - 0 - 3 2 3 - 8 5 6 1 9 - 5
eBook
9 7 8 - 0 - 3 2 3 - 8 5 6 2 0 - 1

Insect Anatomy: Structure and Function provides both morphological and anatomical descriptions of insect tissues and organs using updated methods. Insects play important roles in diverse ecosystems, with subsequent, tremendous impacts on human society through disease, agriculture effects, and more. Both beneficial and detrimental insect species continuously challenge agriculture and medicine. Written by international experts of insect morphology and anatomy, this book offers concise descriptions of all part of an insect’s anatomy, including the brain and nervous system, tracheal system, blood, reproductive organs, and kidney system.The book also covers external insect parts such as antennae, wings and different forms of insect epidermis. Insect tissues and organs are analyzed as they relate to gene and protein function in distinct types of cells, tissues, and organs.

Endovascology

1st Edition
November 1, 2024
Zaiping Jing + 2 more
English
Paperback
9 7 8 - 0 - 3 2 3 - 8 9 9 2 7 - 7
eBook
9 7 8 - 0 - 3 2 3 - 8 8 5 9 2 - 8

Vascular diseases have high incidence, disability and mortality rates. Endovascular treatment is an important option as an alternative to open surgery, with the proven ability to counter severe pathologies. China-based research into vascular diseases and endovascular surgery has been proceeding apace. Endovascology presents, for the first time, the latest research, clinical outcomes, and research frontiers from one of the leading institutes in China specializing in endovascular surgery — the Vascular Surgery Department of Changhai Hospital.Specifically, in this book, chapters cover each aspect of vascular disease: Vascular heart disease; Congenital heart disease; Arteriosclerotic heart disease; Thoracic aortic pathology; Thoracoabdominal aortic pathology; Infrarenal abdominal aortic pathology; Cerebral perfusion arteries; Upper limb vessels; Abdominal visceral arteries; Iliac artery; Lower limb artery; Varicose veins; Deep venous thrombosis of the lower limb; Pelvic congestion syndrome; Inferior vena cava and portal vein; Pulmonary artery; and Lymphatic diseases.Endovascology: Endovascular Treatment of Vascular Systematic Pathologies presents a global medical audience with an ambitious, systematic and exhaustive review of vascular diseases, and the state-of-the art in clinical research and practice in endovascology. It will be of use to surgeons, trainees in minimally invasive cardiovascular techniques, vascular disease researchers, and medical students alike.

Engineered Nanomaterials for Agricultural Sustainability

1st Edition
November 1, 2024
Sanghamitra Majumdar + 1 more
English
Paperback
9 7 8 - 0 - 3 2 3 - 9 0 6 1 7 - 3
eBook
9 7 8 - 0 - 3 2 3 - 9 1 4 3 4 - 5

Engineered Nanomaterials for Agricultural Sustainability: Current Status, Methods and Future Strategies addresses the bottleneck between the development and implementation of nanotechnology created by the knowledge gap in the science, regulation and impact on both the environment and consumers. The book presents the latest insights from studies on the mechanisms and fate of nanomaterials in plants in a structured and organized way that enables the reader to design nanomaterials for specific agricultural applications, avoid undesirable effects on those plants, and to identify the most appropriate path forward toward commercial application.With important insights into the regulatory constraints, this volume will be a go-to reference for those seeking to find strategies for using nanomaterials and nanotechnology to improve agricultural output and food security.

Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

1st Edition
November 1, 2024
Theresa Coetzer
English
Paperback
9 7 8 - 0 - 3 2 3 - 9 1 8 0 1 - 5
eBook
9 7 8 - 0 - 3 2 3 - 9 7 2 0 4 - 8

Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolytic Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.