Viral Vectors

Gene Therapy and Neuroscience Applications

Edited By

  • Michael Kaplitt, New York Hospital, Cornell University Medical College and Laboratory of Neurobiology and Behavior, The Rockefeller University, New York, U.S.A.
  • Arthur Loewy, Washington University, St. Louis, Missouri, U.S.A.


Book information

  • Published: August 1995
  • ISBN: 978-0-12-397570-6

Table of Contents

Herpes Simplex Virus as a Gene Delivery Vector for the Central Nervous System. Biology of Herpes Simplex Virus (HSV) Defective Viruses and Development of the Amplicon System. Group C Adenoviruses as Vectors for Gene Therapy. Genetics and Biology of Adeno-Associated Virus. Genetics and Biology of Retroviral Vectors. HSV Vectors in the Mammalian Brain: Molecular Analysis of Neuronal Physiology, Generation of Genetic Models, And Gene Therapy of Neurological Disorders. The Use of Defective Herpes Simplex Virus Amplicon Vectors to Modify Neural Cells and the Nervous System. Viral Vector-Mediated Gene Transfer in the Nervous System: Application to the Reconstruction of Neural Circuits in the Injured Mammalian Brain. The Use of Herpes Simplex Virus Vectors for Protection from Necrotic Neuron Death. In Vivo Promoter Analysis in the Adult Central Nervous Systems Using Viral Vectors. Adenoviral Mediated Gene Transfer: Potential Therapeutic Applications. Transfer and Expression of Potentially Therapeutic Genes Into the Mammalian Central Nervous System in Vivo Using Adeno-Associated Viral Vectors. Genetic Modification of Cells with Retrovirus Vector for Grafting Into the Central Nervous System. Virus Vector-Mediated Transfer of Drug-Sensitivity Genes for Experimental Brain Tumor Therapy. Brain Tumor Therapy Using Genetically Engineered Replication-Competent Virus. Transfer and Expression of Antioncogenes and Paraneoplastic Genes in Normal and Neoplastic Cells in Vitro and in Vivo. Transneuronal Tracing with Alphaherpesviruses: A Review of the Methodology. Pseudorabies Virus Replication and Assembly in the Rodent Central Nervous System. Pseudorabies Virus Replication and Assembly in the Rodent Central Nervous System. Pseudorabies Virus: A Transneuronal Tracer for Neuroanatomical Studies. Molecular Properties of Alphaherpesviruses Used in Transneuronal Pathway Tracing. Molecular Analysis of Rabies and Pseudorabies Neurotropism. The Use of Retroviral Vectors in the Study of Cell Lineage and Migration During the Development of the Mammalian Central Nervous System. Retroviral Vectors for the Study of Neuroembryology: Immortalization of Neural Cells. References. Index.