Trophic Regulation of the Basal Ganglia
Focus on Dopamine NeuronsEdited by
- K. Fuxe, Karolinska Institutet, Stockholm, Sweden
- L.F. Agnati, University of Modena, Italy
- B. Bjelke, Karolinska Institutet, Stockholm, Sweden
- D. Ottoson, Wenner-Gren Center Foundation, Stockholm, Sweden
Since 1940 brain and pituitary extracts have been known to be capable of stimulating the proliferation of cultured fibroblasts. In 1974, one of these substances was partially purified and named FGF; later it was realised there exists a family of fibroblast growth factors, of which the best characterised are the FGF-1 and FGF-2 (aFGF, bFGF). More recent work has shown that FGFs have many actions and that they are active not only on fibroblasts, but also on a wide range of cell types including those of the central nervous system. This volume represents the state-of-the-art of our understanding of aFGF and bFGF in the basal ganglia. Thus, the localisation of those growth factors, the control mechanisms of their expression, and their trophic actions are analysed in relation to nerve cell survival as well as to the neurodegenerative diseases affecting the basal ganglia. Some of the most advanced research on degenerative and regenerative features of the basal ganglia is also presented. These studies involve the actions of neurotrophins, epidermal growth factors, gangliosides and neuropeptides as well as their localisation and expression in the basal ganglia. These discoveries will help towards understanding the interactions between trophic factors and transmitters in the control of nerve cell function and their phenotypic maintenance; the studies in this work provide the appropriate background knowledge necessary to fully appreciate the impact of present FGF research on the trophic regulation of the basal ganglia.
For neuroscientists, neurologists, psychiatrists and others with an interest in the basal ganglia.
Wenner-Gren International Series
Published: March 1994
- Section headings and selected papers. Fibroblast growth factor-2, ganglioside GM1 and the trophic regulation of the basal ganlia. Focus on the nigrostriatal dopamine neurons (K. Fuxe et al.). Muscle-derived differentiation factor and its regulation of the tyrosine hydroxylase gene in the developing, adult and lesioned rat brain (L. Iacovitti). Oxidative stress and reduced receptor responsiveness in senescence (J.A. Joseph, G.S. Roth). Expression, regulation and receptor distribution of neurotrophins in the mammalian central nervous system. (H. Persson et al.). Localization of neurotrophins and their receptors at the mRNA and protein level (L. Olson et al.). Effects of brain-derived neurotrophic factor on injured dopaminergic neurons (F. Hefti et al.). Neuropeptide synthesis in astrocytes: possible trophic roles (J.P. Schwartz et al.). Neuron-glia interactions: receptor induced events in single astroglial cells and their implications for neuronal excitability and for neurotransmission (E. Hansson et al.). Neurochemical and behavioural studies on L-dopa toxicity in the model of manganese lesioned nigrostriatal pathway in the rat: evidence for a protective effect of the GM1 lactone siagoside (G. Biagini et al.). Compensatory neurobiological changes after partial lesions with 6-hydroxydopamine (M.J. Zigmond). Clearance and diffusion of locally applied dopamine in normal and 6-hydroxydopamine-lesioned rat striatum (B.J. Hoffer et al.). The pharmacotherapy of Parkinson's Disease: current status and future opportunities (T.N. Chase, M.M. Mouradian). Signal transduction mechanisms on striatal dopaminergic neurons: importance in neurotrophism and neuropathology (E. Costa). Author index. Subject index.