Transgenerational Epigenetics book cover

Transgenerational Epigenetics

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.

Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.

This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.

Audience

Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disorders

Hardbound, 412 Pages

Published: May 2014

Imprint: Academic Press

ISBN: 978-0-12-405944-3

Contents

    1. Transgenerational Epigenetics
    2. Historical Perspective of Transgenerational Epigenetics
    3. Epidemiology of Transgenerational Epigenetics
    4. Metastable Epiallels
    5. Paramutations
    6. Epigenetic Silencing of Transgenes
    7. Epigenetic Inheritance of Repeat Sequences
    8. Histone-mediated Transgenerational Epigenetics
    9. Heritable Generational Effects Through RNA
    10. Animal Models of Transgenerational Epigenetic Effects
    11. Plant Models of Transgnerational Epigenetic Inheritance
    12. Transgenerational Epigenetic Effects in Plants
    13. Maternal Epigenetic Inheritance
    14. Paternal Epigenetic Inheritance
    15. Evolution of Transgenerational Epigenetic Inheritance
    16. Heritable Epigenetics Over Multiple Generations
    17. Maternal Stress Effects on Transgenerational Epigenetics
    18. Preimplantation Environment and Epigenetic Transgenerational Inheritance
    19. Transgenerational Epigenetic Inheritance and Human Disease
    20. Environmental Transgenerational Epigenetic Effects
    21. Transgenerational Epigenetics of Endocrine Disruptors
    22. Effects of Transgenerational Epigenetics on Longevity
    23. Transgenerational Epigenetic Effects of an Environmental Enrichment on Memory Formation
    24. Dietary Effects on Transgenerational Epigenetic Inheritance
    25. Clinical Applications of Transgenerational Epigenetics
    26. Transgenerational Epigenetics: Current Controversies
    27. Future Directions of Transgenerational Epigenetic Research

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