Transgenerational Epigenetics

Edited by

  • Trygve Tollefsbol, Professor of Biology, University of Alabama at Birmingham, AL, USA

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes.

Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations.

This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research.

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Audience

Graduate students researching the fundamental basis of epigenetics to therapeutic interventions into epigenetic-based disorders

 

Book information

  • Published: May 2014
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-405944-3

Reviews

"This book is unique in its focus solely on this subject. This is an area destined to become extremely important in the practice of human and medical genetics. This book is without comparison. Score: 99 - 5 Stars"--Doodys.com, January 23, 2015

"...this seminal book on transgenerational epigenetics not only confronts these controversies, but also illuminates many other aspects of transgenerational epigenetics."--Anticancer Research, January 2015




Table of Contents

  1. Transgenerational Epigenetics
  2. Historical Perspective of Transgenerational Epigenetics
  3. Epidemiology of Transgenerational Epigenetics
  4. Metastable Epiallels
  5. Paramutations
  6. Epigenetic Silencing of Transgenes
  7. Epigenetic Inheritance of Repeat Sequences
  8. Histone-mediated Transgenerational Epigenetics
  9. Heritable Generational Effects Through RNA
  10. Animal Models of Transgenerational Epigenetic Effects
  11. Plant Models of Transgnerational Epigenetic Inheritance
  12. Transgenerational Epigenetic Effects in Plants
  13. Maternal Epigenetic Inheritance
  14. Paternal Epigenetic Inheritance
  15. Evolution of Transgenerational Epigenetic Inheritance
  16. Heritable Epigenetics Over Multiple Generations
  17. Maternal Stress Effects on Transgenerational Epigenetics
  18. Preimplantation Environment and Epigenetic Transgenerational Inheritance
  19. Transgenerational Epigenetic Inheritance and Human Disease
  20. Environmental Transgenerational Epigenetic Effects
  21. Transgenerational Epigenetics of Endocrine Disruptors
  22. Effects of Transgenerational Epigenetics on Longevity
  23. Transgenerational Epigenetic Effects of an Environmental Enrichment on Memory Formation
  24. Dietary Effects on Transgenerational Epigenetic Inheritance
  25. Clinical Applications of Transgenerational Epigenetics
  26. Transgenerational Epigenetics: Current Controversies
  27. Future Directions of Transgenerational Epigenetic Research