The Somatotrophic Axis in Brain Function
- Fred Nyberg, Uppsala University, Sweden
The somatotropic axis is one of the major hormonal systems regulating postnatal growth in mammals. It interacts with the central nervous system on several levels. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) receptors are expressed in many brain areas including the hippocampus, pituitary and hypothalamus. GH and IGF-I are important factors in the development and differentiation of the CNS and have protective properties in dementia, as well as in traumatic and ischaemic injury of the CNS. Also GH has an important impact on mood and well-being with GH secretory capacity being reduced in depression.This volume will include chapters (1) on basic knowledge on GH/IGF-1, (2) on localization of GH/IGF-1 and their receptors in the CNS, including blood brain barrier transport of both hormones, (3) on actions of the two hormones on CNS function (basic science), (4) on clinical aspects of GH/IGF-1 in relation to various CNS functions and disorders, and finally (5) on some future perspectives in this area of science.View full description
Basic scientists and clinical researchers in neurology, endocrinology, and neuroscience.
- Published: November 2005
- Imprint: ACADEMIC PRESS
- ISBN: 978-0-12-088484-1
"Because of its breadth, this book will be a useful resource for both research scientists and clinicians. For the established scientist, the chapters provide a good brush-up and ready source of references; whereas for the new clinician or scientist entering the GH-CNS field, it will provide a strong and broad introduction to the field and a fairly comprehensive basis to build upon." --BRAIN, BEHAVIOR AND IMMUNITY (September 2006)
Table of ContentsI. Biosynthesis of GH and IGF-I and Regulation of Their Secretion.II. GH and IGF-I and their Function at Receptor Level.III. Growth Hormone and Insulin-like Growth Factors and Their Receptors in the Central Nervous System.IV. CNS Action of Growth Hormone: Basic Studies Using Animal Models.V. Immediate and Long-Term Benefits on the CNS and GH Replacement Therapy.VI. GH Replacement and Related Therapies in CNS Disorders: A Future Perspective.