The Roots of Organic DevelopmentEdited by
- J.-R. Desmurs, Rhône-Poulenc Industrialisation, Saint Fons, France
- S. Ratton, Rhône-Poulenc Organic Intermediates Enterprise, Courbevoie, France
The development of organic intermediates requires high performance and original technologies. This book reviews recent work on some fifteen basic technologies in intermediates development including; hydrogenation, fluorination, chlorination, nitration, enzymatic catalysis, hydroxylation, alkylation, carboxylation and the Friedel Crafts reaction. Problems and industrial constraints involved in industrial development are highlighted from a research viewpoint and new technologies with potential for use in industry, particularly catalyst-based technologies clean chemical processes, are described. A chapter dealing with reviews on sodium amidure and polymerisation inhibitors is included.
Industrial Chemistry Library
Published: April 1996
- Foreword (B. Louvet, T. Ziemann). Preface (C. Jeanmart, J.M. Lehn). Acknowledgements. Introduction (J.-R. Desmurs et al.). Synthesis. ACYLATION. Friedel-Crafts acylation: Interactions between Lewis acids/acyl chlorides and Lewis acids/aryl ketones (R. Ashforth, J.-R. Desmurs). Bismuth(III) salts in the Friedel-Crafts acylation (J.-R. Desmurs et al.). Friedel-Crafts acylation of aromatics using zeolites (M. Spagnol et al.). CoCl2 catalyzed trifluoroacetylation of aromatics using trifluoroacetic anhydride (J. Ruiz et al.). ALKYLATION. Catalysis by rare earth phosphate II: Selective O-methylation of phenols by methanol in vapor phase (L. Gilbert et al.). Catalysis by rare earth phosphate III: Characterisation of samarium phosphate and samarium phosphate-cesium hydrogenophosphate as key catalysts for O-alkylation of phenols (A.M. Le Govic et al.). AROMATIC FUNCTIONALISATION. Selective functionalisation of fluoroaromatics via organosilicon intermediates (B. Bennetau et al.). Arylation of amines and alcohols catalyzed by nickel, copper or palladium complexes (H.J. Cristau et al.). The isomerisation of 1,2,4-trichlorobenzene: A theoretical study (S. Firkins). CARBOXYLATION. Carboxylation of hydroxy aromatic compounds (I. Bonneau-Gubelmann et al.). CHLORINATION. Access to polychlorophenols, chemistry of intermediates (J.-R. Desmurs et al.). Diastereoselective halogenations (P. Duhamel). ENZYMATIC CATALYSIS. Enzymatic hydrolysis of adiponitrile into 5-cyanovaleric acid, an intermediate for Nylon 6 (E. Cerbelaud et al.). FLUORINATION. Reagents with trifluoromethyl substituents (H.G. Viehe, Z. Janousek). Fluorination of aromatic compounds by halogen exchange with fluoride anions (
Halexreaction) (B. Langlois et al.). 4-Fluorophenol: A key intermediate for agrochemicals and pharmaceuticals (C. Mercier, P. Youmans). Fluorodecarboxylation of arylchloroformate: A new access to fluoroaromatics (H. Garcia et al.). Mild trifluoromethylation of organic compounds (C. Wakselman, M. Tordeux). FORMYLATION. Formylation of aromatic compounds in superacidic medium (L. Saint-Jalmes et al.). HYDROGENATION. High selectivities in hydrogenation of halogenonitrobenzenes on Pd, Pt or Raney Nickel as catalysts (G. Cordier et al.). HYDROXYALKYLATION. Influence of the cation in condensation of glyoxylic acid on phenols in aqueous hydroxide solution (M.F. Wuthrick, C. Maliverney). HYDROXYLATION. Selective access to hydroquinone
Fuchsoneroute (M. Costantini et al.). NITRATION. The mechanisms of nitration of phenol (P. Métivier, T. Schlama). OXIDATION. Oxidation of alkylphenols to hydroxybenzaldehydes (E. Fache et al.). Large pore Ti-Beta zeolite with very low aluminium content: An active and selective catalyst for oxidations using hydrogen peroxide (M.A. Camblor et al.). PEPTIDE SYNTHESIS. Peptide synthesis by SAPPHO technology (J.M. Bernard et al.). A new and practical removal of allyl and allyloxycarbonyl group promoted by water-soluble Pd(0) catalysts (S. Lemaire-Audoire et al.). Safety. Safety of chlorination reactions (J.L. Gustin, A. Fines). Applications. Sodium amide in organic synthesis (J.M. Poirier). Delivery systems for controlled release of active materials (C. Prud'homme). Anisole: An excellent solvent (J.-R. Desmurs, S. Ratton). The use of phenolic compounds as free-radical polymerization inhibitors (F. Lartigue-Peyrou). Analysis. Tracing back the origin of vanillin by SNIF-NMR (G.J. Martin). NMR under high gas pressure (F. Metz et al.). Lactic derivatives: Methods for determining the optical purity of various intermediates (F. Marcenac et al.). Author Index. Subject Index.