The Neuroscience of Autism Spectrum Disorders

Edited by

  • Joseph Buxbaum, Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
  • Patrick Hof, Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA

Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder.  New research is leading to greater understanding of and ability to treat the disorder at an earlier age.  It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention.

Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years.  With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models.  Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage.  Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise.

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Neuroscientists at all levels interested in neurodevelopmental disorders and autism, autism specialists looking to expand their expertise


Book information

  • Published: October 2012
  • ISBN: 978-0-12-391924-3

Table of Contents

Section 1: Autism Spectrum Disorders
1.1 Epidemiology of autism spectrum disorders - Eric Fombonne and Lisa R. French
1.2 The behavioral manifestations of autism spectrum disorders - So Hyun Kim and Catherine Lord
1.3 Early manifestations of autism spectrum disorders - Marianne Barton and Deborah Fein
1.4 Asperger Syndrome and Its Relationship to Autism Spectrum Disorders - Fred Volkmar and James McPartland
1.5 Behavioral and Psychosocial Interventions for Individuals with ASD - Latha Soorya
1.6 Current Trends in the Pharmacological Treatment of Autism Spectrum Disorders - Alexander Kolevzon
1.7 Novel therapeutics in autism spectrum disorders - Evdokia Anagnostou

Section 2: Etiology of Autism Spectrum Disorders
2.1 Medical genetics and autism spectrum disorders - Catalina Betancur
2.2 Copy Number Variation in Autism Spectrum Disorders - Stephen Scherer and Christian Marshall
2.3 Common genetic variants in autism spectrum disorders - Richard JL Anney
2.4 Next-Generation Sequencing for Gene and Pathway Discovery and Analysis in Autism Spectrum Disorders - Joseph Buxbaum and Guiqing Cai
2.5 Mitochondria and Autism Spectrum Disorders - Robert Naviaux
2.6 Parental and perinatal risk factors in ASDs - Avi Reichenberg
2.7 The Environment in autism spectrum disorders - Irva Hertz-Picciotto, Kristen Lyall and Rebecca Schmidt
2.8 Hormonal influences in typical development: Implications for autism - Bonnie Auyeung and Simon Baron-Cohen
2.9 Immune abnormalities and autism spectrum disorders - Judy Van de Water

Section 3: Brain Imaging and Neuropatholgy of Autism Spectrum Disorders
3.1 Structural and functional MRI studies of autism spectrum disorders - Kimberly Stigler
3.2 DTI and tractography in the autistic brain - Tim Roberts
3.3 Attentional network deficits in autism spectrum disorders - Jin Fan
3.4 The cerebellum in autism spectrum disorders - Margaret Bauman
3.5 The amygdala in autism spectrum disorders - Cynthia M. Schumann
3.6 Discrete cortical neuropathology in autism spectrum disorders - Patrick R. Hof
3.7 The minicolumnopathy of autism spectrum disorders - Manuel F. Casanova
3.8 Inhibitory and excitatory systems in autism spectrum disorders - Gene J. Blatt
3.9 Clinicopathological Stratification of Idiopathic Autism and Autism Associated with 15q11.2-q13 Duplications - Jerzy Wegiel

Section 4: Model Systems and Pathways in Autism Spectrum Disorders
4.1 Mouse behavioral models for autism spectrum disorders - William C. Wetsel
4.2 Nonhuman primate models for autism spectrum disorders - David Amaral
4.3 Inducible pluripotent stem cells in ASDs - Alysson R. Muotri
4.4 A 15q11-q13 duplication mouse model for autism spectrum disorders - Toru Takumi
4.5 Fragile X syndrome and autism spectrum disorders - W. Ted Brown
4.6 MECP2 and autism spectrum disorders - Janine LaSalle
4.7 SHANK2 and SHANK3 Mutations Implicate Glutamate Signaling Abnormalities in Autism Spectrum Disorders - Joseph Buxbaum and Hala Harony-Nicholas
4.8 PI3K signaling and miRNA regulation in autism spectrum disorders - Mriganka Sur
4.9 Getting from 1000 genes to a triad of symptoms: The emerging role of systems biology in autism spectrum disorders - Joseph Buxbaum