The Molecular Biology of Arrestins

This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.
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Students, researchers, microbiologists, molecular biologists


Book information

  • Published: June 2013
  • ISBN: 978-0-12-394440-5


"Full of interest not only for the molecular biologist-for whom the numerous references will be invaluable-but will also appeal to a much wider circle of biologists, and in fact to all those who are concerned with the living cell."--BRITISH MEDICAL JOURNAL

Table of Contents

Part I: Perspective - The Duality of Arrestin Function

1. Arrestins Come of Age: A Personal Historical Perspective

Part II: The Molecular Biology of Arrestins

    2. True Arrestins and Arrestin-Fold Proteins: A Structure-Based Appraisal

    3. Structural Determinants of Arrestin Functions

    4. Arrestins: Role in the Desensitization, Sequestration and Vesicular Trafficking of G Protein-Coupled Receptors

    5. Arrestins as Regulators of Kinases and Phosphatases

    6. ß-Arrestins: Modulators of Small GTPase Activation and Function

    7. Arrestins and Protein Ubiquitination

    8. Arrestins in Actin Reorganization and Cell Migration

    Part III: The Physiological Roles of Arrestins

      9. The Role of Arrestins in Development

      10. The Role of Arrestins in Visual and Disease Processes of the Eye

      11. b-Arrestins in the Central Nervous System

      12. Arrestins in the Cardiovascular System

      13. Arrestins in Bone

      14. b-Arrestins in the Immune System

      15. The Role of b-Arrestins in Cancer

      16. Arrestins in Metabolic Regulation

      Part IV: The Future - The Potential for Arrestin-based Therapeutics

        17. Systems Analysis of Arrestin Pathway Functions

        18. Arrestin Pathways as Drug Targets