The Mitochondrion in the Germline and Early Development

Series Editor:

  • Gerald Schatten, University of Pittsburgh School of Medicine, PA, U.S.A.

Edited by

  • Justin St. John, The Medical School, The University of Birmingham, U.K.

Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. These volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology.
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Developmental biologists, cell biologists, genetics researchers, molecular biologists, and plant and animal biologists


Book information

  • Published: January 2007
  • ISBN: 978-0-12-373662-8

Table of Contents

Section I. The mitochondrion and gametesChapter 1The role of the mitochondrion in sperm function. Is there a place for oxidative phosphorylation or is this a purely glycolytic process?Eduardo Ruiz-Pesini, Carmen Díez-Sánchez, Manuel José López-Pérez and José Antonio EnríquezChapter 2The role of mitochondrial function in the oocyte and embryoRemi Dumollard, Michael Duchen, John CarrollChapter 3Mitochondrial DNA in the Oocyte and the developing embryoPascale May-Panloup, Marie-Françoise Chretien, Yves Malthier, Pascal ReynierSection II. TransmissionChapter 4Mitochondrial DNA and the mammalian oocyteEric A. Shoubridge and Timothy WaiChapter 5Mitochondrial disease - its impact, aetiology and pathologyMcFarland R, Taylor RW and Turnbull DMChapter 6Cybrid models of mtDNA disease and transmission, from cells to miceIan A. Trounce, Carl A. Pinkert Section III. The use of ARTs to regulate mtDNA disease.Chapter 7The use of Micromanipulation Methods as a Tool to Prevention of Transmission of Mutated Mitochondrial DNAHelena Fulka, Josef Fulka, Jr.Chapter 8Difficulties and possible solutions in the Genetic Management of mtDNA disease in the pre-implantation embryoJoanna Poulton, Pippa Oakeshott, Stephen H. KennedySection IV. The effects of invasive ARTs on mtDNA transmissionChapter 9Impact of assisted reproductive techniques: a mitochondrial perspective from the cytoplasmic transplantion Carol Brenner, A. J. Harvey, T. C. GibsonChapter 10Nuclear Transfer – preservation of a nuclear genome at the expense of its associated mtDNA genome(s)Emma J. Bowles, Keith H. S. Campbell, Justin C. St. John