The Genetics of Cancer

Genes Associated with Cancer Invasion, Metastasis and Cell Proliferation


  • Gajanan Sherbet, School of Electrical Electronic and Computer Engineering,University of Newcastle upon Tyne UK and The Institute for Molecular Medicine, Huntington Beach, CA, USA
  • M. Lakshmi, Cancer Research Unit, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, U.K.

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology.
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Graduates, research scientists, and research clinicians in cancer biology, oncology, pathology, genetics, molecular biology, and biomedicine in general.


Book information

  • Published: June 1997
  • ISBN: 978-0-12-639875-5


"Overall this book provides an excellent and often critical overview of the current state of knowledge of the genes associated with invasion and metastasis and those processes associated with it. It is a very good source of references for seminal papers and reviews, which are quite will make a very useful and readable introduction to the genetics of tumor invasion and metastasis and to the concepts that underlie it."

"The book's greatest strength is in compiling and extensively referencing the massive and often paradoxical clinical literature correlating the expression patterns of cancer genes with different tumor phenotypes."

Table of Contents

Preface.Acknowledgement.Introduction.Clonal Evolution of Metastasis.Inefficiency of the Metastatic Process.Tumor Growth and Metastatic Potential.Cell Cycle Regulation and Metastasis.Apoptosis in Tumor Growth and Metastasis.Angiogenesis in Cancer.Cell Surface Glycoproteins and Their Receptors.Proteinases and Their Inhibitors in Cancer Invasion.Oncogenes and Cancer Metastasis.Developmental Genes and Their Putative Tumor Suppressor Function.Tumor Suppressor Genes.Metastasis Suppressor Genes.Dominant Metastasis Associated Genes.Epilogue.References.