The Bioarchaeology of Metabolic Bone Disease book cover

The Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease provides a comprehensive and invaluable source of information on this important group of diseases. It is an essential guide for those engaged in either basic recording or in-depth research on human remains from archaeological sites. The range of potential tools for investigating metabolic diseases of bone are far greater than for many other conditions, and building on clinical investigations, this book will consider gross, surface features visible using microscopic examination, histological and radiological features of bone, that can be used to help investigate metabolic bone diseases.

Audience
A wide range of individuals engaged in the study of physical anthropology, paleopathology, medical history and forensic anthropology.

Hardbound, 350 Pages

Published: April 2008

Imprint: Academic Press

ISBN: 978-0-12-370486-3

Reviews

  • "[Bioarchaeology of Metabolic Bone Disease] takes us along a fascinating exploratory journey of the main (and not so common) metabolic bone diseases identifiable in skeletal remains. Useful supporting tables, and clear photographic images and line drawings, supplement the text, with a concluding chapter providing a view of future research...."

    Professor Charlotte A. Roberts
    Department of Archaeology
    Durham University

    "The authors’ cogent discussion of how elements within a given lifestyle, including diet/nutrition, cultural practices, socio-economic status, and the surrounding environment, can significantly impact the health of individuals and of societies is illustrated with abundant well-chosen anthropological examples. This volume will be of great value to all scholars devoted to accurate, informative reconstructions of past human life."

    Mary Lucas Powell, Ph.D.
    Past Editor, Paleopathology Newsletter
    The Paleopathology Association

Contents


  • Acknowledgments

    Foreword

    Chapter 1. Introduction

    Metabolic Bone Disease: A Definition

    Format of the Book

    Chapter 2. The Study of Metabolic Bone Disease in Bioarchaeology

    Approaches to the Study of Metabolic Bone Disease

    Challenges in the Investigation of Metabolic Bone Disease

    Museum Collections

    Archaeological Human Bone

    Paleopathological Diagnoses

    Demographic Issues

    Modern Medical Data

    Genetics and Anthropology

    Cultural and Social Anthropology

    Nutritional and Medical Anthropology

    Primatology

    Conclusions

    Chapter 3. Background to Bone Biology and Mineral Metabolism

    Bone Tissue: Cortical and Trabecular Bone

    Different Types of Bone Structure: Woven Bone and Lamellar Bone

    Bone Cells

    Modeling and Remodeling: Growth and Adulthood

    Mechanisms of Growth

    Modeling

    Remodeling

    Bone Mineralization: The Extracellular Matrix (osteoid)

    Tooth Formation and Mineralization

    Reasons for Remodeling

    Box Feature 3.1. Bone Biology in Context of the Life Course

    Bone Biology in Fracture Healing

    Mineral Metabolism during Life

    Extracellular Mineral Metabolism

    Conclusions

    Chapter 4. Vitamin C Deficiency Scurvy

    Causes of Vitamin C Deficiency

    Sources of Vitamin C

    Box Feature 4.1. Scurvy and Weaning

    The Role of Vitamin C

    Vitamin C Requirements

    Consequences of Scurvy

    Consequences for Adults

    Consequences for Children

    Scurvy in the Modern Perspective

    Anthropological Perspectives

    Reference to Probable Scurvy in Early Texts

    Box Feature 4.2. Subsistence Change and the Development of Scurvy: The Origins of Agriculture

    A More Recent View of Scurvy in the Past

    Paleopathological Cases of Scurvy

    Diagnosis of Scurvy in Archaeological Bone

    Macroscopic Features of Infantile Scurvy

    Macroscopic Features of Adult Scurvy

    Radiological Features of Infantile Scurvy

    Radiological Features of Adult Scurvy

    Histological Features of Infantile Scurvy

    Histological Features of Adult Scurvy

    Differential Diagnosis

    Box Feature 4.3. Scurvy in Non-Human Primates: A Result of Human Actions

    Conclusions

    Appendix: Summary of Published Archaeological Evidence for Vitamin C Deficiency

    Chapter 5. Vitamin D Deficiency

    The Skeletal Requirement of Vitamin D

    Terminology

    Causes of Vitamin D Deficiency

    Sunlight

    Cultural Practices and Sunlight Exposure

    Skin Pigmentation and Genetic Adaptations

    Food Sources

    Pregnancy and Lactation

    Increased Age

    Age-Related Osteoporosis

    Additional Causes of Vitamin D Deficiency with Effects on Mineral Metabolism

    Rickets

    Consequences of Rickets

    Historical Recognition of Rickets

    Rickets in the Modern Perspective

    Anthropological Perspectives: Rickets

    Box Feature 5.1. Beyond Fighting: The Physiological Impact of Warfare

    Paleopathological Cases of Rickets

    Diagnosis of Rickets in Archaeological Bone

    Macroscopic Features of Rickets

    Radiological Features of Rickets

    Histological Features of Rickets

    Residual Rickets in the Anthropological Perspective: Adult Evidence of Childhood Vitamin D Deficiency

    Diagnosis of Residual Rickets in Archaeological Bone

    Macroscopic Features of Residual Rickets

    Radiological Features of Residual Rickets

    Histological Features of Rickets

    Co-Morbidities

    Differential Diagnosis

    Vitamin D Deficiency Osteomalacia

    Pseudofractures

    Adult Vitamin D Deficiency in the Modern Perspective

    Box Feature 5.2. Physical and Non-Violent Manifestations of Abuse

    Anthropological Perspectives: Osteomalacia

    Paleopathological Cases of Osteomalacia

    Diagnosis of Osteomalacia in Archaeological Bone

    Macroscopic Features of Osteomalacia

    Radiological Features of Osteomalacia

    Histological Features of Osteomalacia

    Conclusions

    Appendix: Summary of Published Archaeological Evidence for Vitamin D Deficiency

    Chapter 6. Age-Related Bone Loss and Osteoporosis

    Definitions of Osteoporosis

    Causes of Age-Related Osteoporosis

    Menopause

    Increased Age

    Peak Bone Mass

    Mechanical Loading

    Extremes of Exercise

    Continuing Sub-Periosteal Apposition

    Genetics and Population Groups

    Nutrition and Lifestyle

    Skeletal Features of Age-Related Osteoporosis

    Consequences of Age-Related Osteoporosis: Fractures

    Distal Radius Fractures (Colles ’ Fractures)

    Vertebral Fractures

    Femoral Fractures

    Osteoporosis in the Modern Perspective

    Anthropological Perspectives

    Box Feature 6.1. Historical and Anthropological Perspectives of Aging

    Age-Related Osteoporosis in Men

    Box Feature 6.2. Animal Studies in Osteoporosis I: Age-Related Bone Loss

    Box Feature 6.3. Problems in the Determination of Age-Related Bone Changes in Biological Anthropology

    Paleopathological Cases of Age-Related Osteoporosis

    Co-Morbidities

    Diagnosis of Age-Related Bone Loss and Osteoporosis in Archaeological Bone

    Macroscopic Features of Osteoporosis

    Radiological Features of Osteoporosis

    Histological Changes of Osteoporosis

    Conclusions

    Chapter 7. Secondary Osteopenia and Osteoporosis

    Causes of Secondary Osteopenia and Osteoporosis

    Osteopenia and Mobility

    Effects of Immobilization

    Box Feature 7.1. Animal Studies in Osteoporosis II: Immobilization-Related Osteopenia

    Trauma and Causes of Immobility

    Non-Long Bone Trauma and Additional Causes of Disuse Osteoporosis

    Bone Loss in Infectious Diseases

    Immobility in Viral Conditions

    Congenital and Developmental Conditions

    Osteopenia in Spinal Cord or Neuromuscular System Afflictions

    Box Feature 7.2. Implications of Immobility and Inferences of Disability

    Osteopenia in Pathological Conditions

    Joint Disease

    Hematopoietic Conditions

    Neoplastic and Malignant Conditions

    The Influence of Diet on Osteoporosis Risk

    Dietary Acid Load and Proposed Mechanisms of Bone Loss

    Calcium

    Protein

    Fatty Acids

    Fruit and Vegetables

    Anthropological Perspectives

    Calcium in the Evolutionary Perspective

    The Effect of Meat Eating on Calcium Adequacy

    Box Feature 7.3. The Health of Adaptive and Transitional Diets: Integrated Approaches?

    Calcium Availability with the Onset of Domestication

    Diagnosis of Secondary Osteopenia in Archaeological Bone

    Conclusions

    Chapter 8. Paget’s Disease of Bone

    POSSIBLE CAUSES OF PAGET’S DISEASE

    Box Feature 8.1. Animal Paleopathology

    Consequences of Paget’s Disease

    Pelvic Changes

    Cranial Changes

    Long Bone Changes

    Other Bones that can be Affected

    Co-Morbidities

    Paget’s Disease in the Modern Perspective

    Age and Sex

    Geographic Variation

    Anthropological Perspectives

    Paleopathological Cases of Paget’s Disease

    Diagnosis of Paget’s Disease in Archaeological Bone

    Macroscopic Features of Paget’s Disease

    Radiological Features of Paget’s Disease

    Histological Features of Paget’s Disease

    Differential Diagnosis

    Box Feature 8.2. The Contribution of Paleopathology to Modern Medicine

    Conclusions

    Chapter 9. Miscellaneous Conditions

    Fluorosis

    Consequences of Fluorosis

    Dental Fluorosis

    Skeletal Fluorosis

    Co-Morbidities

    Fluorosis in the Modern Perspective

    Anthropological Perspectives: Fluorosis

    Paleopathological Cases of Fluorosis

    Other Conditions Linked to Intoxication

    Hyperparathyroidism

    Causes of Hyperparathyroidism

    Primary Hyperparathyroidism

    Secondary Hyperparathyroidism

    Consequences of Hyperparathyroidism

    Anthropological Perspectives: Hyperparathyroidism

    Paleopathological Cases of Hyperparathyroidism

    Diagnosis of Hyperparathyroidism in Archaeological Bone

    Pellagra

    Box Feature 9.1. Anthropological Investigations of Displaced Peoples

    Starvation

    Box Feature 9.2. Malnutrition, Starvation and Osteoporosis

    Rare Metabolic Bone Diseases

    Hyperostosis

    Hypophosphatasia

    Osteogenesis Imperfecta

    Osteopetrosis

    Conclusions

    Chapter 10. Overview and Directions for Future Research

    Bone Biology

    Vitamin C Deficiency, Scurvy

    Vitamin D Deficiency, Rickets and Osteomalacia

    Age-Related Osteoporosis

    Secondary Osteopenia and Osteoporosis

    Paget’S Disease of Bone

    Miscellaneous Metabolic Bone Diseases

    Conclusions

    Bibliography

    Index


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