Textbook of Medicinal Chemistry Vol II book cover

Textbook of Medicinal Chemistry Vol II

Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs.

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Published: June 2012

Imprint: Elsevier

ISBN: 978-81-312-3259-0

Contents

  • Preface v

    Acknowledgements vii

    SECTION I Drugs Acting on Inflammation/Allergy 1

    Chapter 1 Antihistamines 3

    • Structure-Activity Relationship-H1 Receptor

    Antagonists • Classification • Synthesis and Drug Profile

    Chapter 2 Prostaglandins 46

    • Functions of PGs • Biosynthesis • Synthesis

    and Drug Profile

    Chapter 3 Analgesics, Antipyretics, and NSAIDs 56

    • Classification • SAR of Salicylates; Synthesis

    and Drug Profile; SAR of p-Amino Phenol

    Derivatives; SAR of 3,5-Pyrazolidine Diones;

    SAR of Anthranilic Acid Derivatives;

    SAR of Aryl Alkanoic Acid Derivatives;

    SAR of Indole Acetic Acid Derivatives; SAR of Oxicams

    SECTION II Drugs Acting on Respiratory System 107

    Chapter 1 Expectorants and Antitussives 109

    • Introduction to Respiratory System • Expectorants and

    Antitussives • Classification • Synthesis and Drug Profile

    Section III Drugs Acting on Digestive System 119

    Chapter 1 Antiulcer Agents 121

    • Classification • Synthesis and Drug

    Profile • SAR of H2-Receptor Antagonists

    Chapter 2 Antidiarrhoeals 137

    • Synthesis and Drug Profile

    SECTION IV Drugs Acting on Blood and Blood-Forming Organs 143

    Chapter 1 Coagulants 145

    • Classification • Anticoagulants;

    Classification; Synthesis and Drug Profile

    Chapter 2 Plasma Expanders 160

    SECTION V Drugs Acting on Endocrine System 163

    Chapter 1 Oral Hypogylcaemic Drugs 165

    • Classification • Synthesis and Drug

    Profile • SAR of Sulphonyl Ureas

    Chapter 2 Steroids 192

    • Steroid Nomenclature and Structure

    • Progestogens • Oestrogens • Androgens and

    Anabolic Agents

    Chapter 3 Antithyroid Drugs 215

    • Classification • Synthesis and Drug Profile

    SECTION VI Chemotherapy 221

    Chapter 1 History and Development of Chemotherapy 223

    • Historical Background • Spectrum of

    Activity of Chemotherapeutic Agents

    Chapter 2 Antibacterial Sulphonamides 229

    • SAR of Sulphonamides • Classification

    • Synthesis and Drug Profile

    Chapter 3 Quinolone Antibacterials 254

    • Effective Antibacterial Quinolone

    Derivatives • Synthesis and Drug Profile • SAR of

    Quinolones

    Chapter 4 Antibiotics 265

    • Classification • Penicillins; Cephalosporins;

    Amino Glycoside Antibiotics; Tetracyclins; Polypeptide

    Antibiotics; Macrolide Antibiotics; Lincomycins; Other

    Antibiotics

    Chapter 5 Antitubercular Agents 331

    • Synthesis and Drug Profile

    Chapter 6 Antifungal Agents 344

    • Classification • Synthesis and Drug Profile

    Chapter 7 Antiviral Agents 364

    • Introduction • Classification • Synthesis and Drug Profile

    • SAR of Amantadine Analogues

    Chapter 8 Antiamoebic Agents 401

    • Classification of Amoebicides • Synthesis

    and Drug Profile

    Chapter 9 Antimalarials 409

    • Life Cycle of Plasmodium • Classification

    • Synthesis and Drug Profile • Structure-Activity

    Relationship

    Chapter 10 Anthelmintics 435

    • Classification • Synthesis and Drug Profile

    Chapter 11 Antineoplastic Agents 455

    • Classification • Synthesis and Drug Profile

    Chapter 12 Antileprotic Drugs 511

    • Classification • Synthesis and Drug Profile

     

     

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