Textbook of Medicinal Chemistry Vol II

Dr Alagarsamy's Textbook of Medicinal Chemistry is a much-awaited masterpiece in its arena. Targeted mainly to B. Pharm. students, this book will also be useful for M. Pharm. as well as M. Sc. organic chemistry and pharmaceutical chemistry students. It aims at eliminating the inadequacies in teaching and learning of medicinal chemistry by providing enormous information on all the topics in medicinal chemistry of synthetic drugs.
View full description

 

Book information

  • Published: June 2012
  • Imprint: ELSEVIER
  • ISBN: 978-81-312-3259-0


Table of Contents

Preface v

Acknowledgements vii

SECTION I Drugs Acting on Inflammation/Allergy 1

Chapter 1 Antihistamines 3

• Structure-Activity Relationship-H1 Receptor

Antagonists • Classification • Synthesis and Drug Profile

Chapter 2 Prostaglandins 46

• Functions of PGs • Biosynthesis • Synthesis

and Drug Profile

Chapter 3 Analgesics, Antipyretics, and NSAIDs 56

• Classification • SAR of Salicylates; Synthesis

and Drug Profile; SAR of p-Amino Phenol

Derivatives; SAR of 3,5-Pyrazolidine Diones;

SAR of Anthranilic Acid Derivatives;

SAR of Aryl Alkanoic Acid Derivatives;

SAR of Indole Acetic Acid Derivatives; SAR of Oxicams

SECTION II Drugs Acting on Respiratory System 107

Chapter 1 Expectorants and Antitussives 109

• Introduction to Respiratory System • Expectorants and

Antitussives • Classification • Synthesis and Drug Profile

Section III Drugs Acting on Digestive System 119

Chapter 1 Antiulcer Agents 121

• Classification • Synthesis and Drug

Profile • SAR of H2-Receptor Antagonists

Chapter 2 Antidiarrhoeals 137

• Synthesis and Drug Profile

SECTION IV Drugs Acting on Blood and Blood-Forming Organs 143

Chapter 1 Coagulants 145

• Classification • Anticoagulants;

Classification; Synthesis and Drug Profile

Chapter 2 Plasma Expanders 160

SECTION V Drugs Acting on Endocrine System 163

Chapter 1 Oral Hypogylcaemic Drugs 165

• Classification • Synthesis and Drug

Profile • SAR of Sulphonyl Ureas

Chapter 2 Steroids 192

• Steroid Nomenclature and Structure

• Progestogens • Oestrogens • Androgens and

Anabolic Agents

Chapter 3 Antithyroid Drugs 215

• Classification • Synthesis and Drug Profile

SECTION VI Chemotherapy 221

Chapter 1 History and Development of Chemotherapy 223

• Historical Background • Spectrum of

Activity of Chemotherapeutic Agents

Chapter 2 Antibacterial Sulphonamides 229

• SAR of Sulphonamides • Classification

• Synthesis and Drug Profile

Chapter 3 Quinolone Antibacterials 254

• Effective Antibacterial Quinolone

Derivatives • Synthesis and Drug Profile • SAR of

Quinolones

Chapter 4 Antibiotics 265

• Classification • Penicillins; Cephalosporins;

Amino Glycoside Antibiotics; Tetracyclins; Polypeptide

Antibiotics; Macrolide Antibiotics; Lincomycins; Other

Antibiotics

Chapter 5 Antitubercular Agents 331

• Synthesis and Drug Profile

Chapter 6 Antifungal Agents 344

• Classification • Synthesis and Drug Profile

Chapter 7 Antiviral Agents 364

• Introduction • Classification • Synthesis and Drug Profile

• SAR of Amantadine Analogues

Chapter 8 Antiamoebic Agents 401

• Classification of Amoebicides • Synthesis

and Drug Profile

Chapter 9 Antimalarials 409

• Life Cycle of Plasmodium • Classification

• Synthesis and Drug Profile • Structure-Activity

Relationship

Chapter 10 Anthelmintics 435

• Classification • Synthesis and Drug Profile

Chapter 11 Antineoplastic Agents 455

• Classification • Synthesis and Drug Profile

Chapter 12 Antileprotic Drugs 511

• Classification • Synthesis and Drug Profile