Systemic Lupus Erythematosus book cover

Systemic Lupus Erythematosus

Systemic lupus erythematosus (S.L.E.), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness. To date, lupus has no known cause or cure. Early detection and treatment is the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, anti-malarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, similar to those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well regarded reference which combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.

Primary audience is basic scientists and clinicians who are interested in SLE including rheumatologists, dermatologists, nephrologists, immunologists and allergists. Secondary audience is residents and fellows in training, primary internists with an interest in the disease and medical libraries.

Hardbound, 1154 Pages

Published: October 2010

Imprint: Academic Press

ISBN: 978-0-12-374994-9


  • "The first edition was published in 1987, and revisions every five or six years have kept this reference up to date. An earlier edition was cited in Brandon-Hill, but, surprisingly, this work is absent from the Medical Library Association's Master Guide.... Like its predecessors, this reference aims for comprehensiveness, and this fifth edition incorporates an abundance of new terms and concepts, key opinions from researchers and clinicians, and, for the first time, ‘...ways to approach, examine and quantify clinical facts from lupus patients.’ Chapters are organized in sections on the basis of disease pathogenesis (e.g. genetics, cellular pathogenesis, humoral pathogenesis, environmental aspects, mechanisms of tissue injury); clinical aspects; anti-phospholipid syndrome; and treatment. Editor Robert G. Lahita (New Jersey Medical School, and Newark Beth Israel Medical Center) is joined for this edition by three associate editors: George Tsokos (Beth Israel Deaconess Medical Center); Jill P. Buyon (NYU Medical Center); and Takao Koike (Hokkaido U. School of Medicine, Japan)."--SciTech Book News


  • Foreword (Evelyn Hess, University of Cincinnati Medical Center)History (Robert G. Lahita)Section I. Basis of Disease Pathogenesis1. GeneticsMHC Class II (J. Reveille, University of Texas at Houston)MHC Class III, Complement(J. Atkinson, Washington University)Constitutive Genes and Lupus (J. Harley, University of Oklahoma Health Sciences Center)Murine Models of SLE and Genetics (A. Theofilopoulos, Scripps Research Institute)2. Cellular PathogenesisDendritic Cells, Antigen Presenting Cells (M Mamula, Yale University School of Medicine)T Cells and SLE (TH 17, TH2, and T-regulatory Cells) (JC Crispin, Mexico)B Cells and SLE (M Doerner, Charity Hospital, Germany)Role of polymorphonuclear leukocytes (B. Cronstein, New York School of Medicine)Apoptosis (P. Cohen, University of Penn)Mitochondrial Damage (Perl, State University of New York)Nitric Oxide (G. Gilkenson) 3. Humoral PathogenesisOrigins of autoantibodies (W. Reeves, University of Florida)Anti DNA (B . Diamond, Albert Einstein College of Medicine, NY)Anti Cytoplasmic Antibody (M. Reichlin, Oklahoma University Health Center)Antihistone, splicesomal Antibody (R. Rubin, University of New Mexico)Cytokines (P. Crow)Interferon alpha and SLE (V. Pascual, Baylor Institute for Immunological Research, Texas)Immune Complexes (M. Wener, University of Washington)4. Environmental Aspects of PathogenesisDrug Induced Lupus ? Basic Science (B. Richardson, University of Michigan)Sex Hormones and Age (R. Lahita)Infections and Lupus TBDTolerance and Autoimmunity TBDNon Murine, Non Human SLE: Dogs, Horses (R. Halliwell, University of Edinburgh) Section II. Clinical Aspects of Disease1. The Clinical PresentationSLE in the Adult (R. Lahita)SLE in the Neonate (J. Buyon, Hospital for Joint Diseases, NY)Childhood Disease (I. Szer, Children's Hospital of San Diego)Drug Induced Disease (B.A. Mongey, University of Cincinnati)Use of Laboratory in Diagnosis (P. Schur, Brigham and Women's Hospital, Boston)Pregnancy (C. Laskin, University of Toronto)Epidemiology of SLE (D. Gladman, Toronto Western Hospital)Overlap Syndromes: Sjogren and MCTD (R. Hoffman, University of Miami)Fibromyalgia and SLE (J. Winfield, University of North Carolina)Imaging of SLE (L. Shapeero, US Military Cancer Institute, Bethesda)Monitoring Disease Activity (M. Liang, Brigham and Women's Hospital, Boston)2. Organ SystemsCNS ? Encephalopathy, Peripheral Nerve Disease (R. Brey, University of Texas Health Center)Cognitive Dysfunction (J. Denburg, McMaster University, Hamilton, Canada)Psychiatric Aspects of SLE (J. Levenson, Virginia Commonwealth University)Skin (C. Nousari, Cleveland Clinic Florida)Kidney (J. Balow, NIH, Bethesda)Heart (S. Manzi, University of Pittsburgh)Vasculitis (G. Hoffman, Cleveland Clinic Foundation)The Lung (E. Clinton Lawrence, Emory University)Gastrointestinal: Hepatic (I. Mackay, Monash University, Australia)Gastrointestinal: Non Hepatic (L. Mayer, Mount Sinai Medical Center, NY)Cellular Hematology: Anemia, thrombocytopenia, Leucopenia (R. Nachman, NY Hospital ? Cornell Medical Center)Musculoskeletal System: articular disease, Bone Metabolism (J. Zuckerman, Hospital for Joint Disease, NY)Eye and Ear and SLE (TBD)Section III. APLS (Antiphospholipid Syndrome)1. Pathogenesis Antiphospholipid_Antibody: Pathogenesis (T. Koike, Hokkaido University, Japan)Endothelial Cell Damage and Atherosclerosis (J. Merrell)Cofactors and Disease (S. Krilis)2. Clinical Laboratory Testing in APLS (TBD)Clinical Presentation (M. Khamashta, St Thomas Hospital, London)Pregnancy and APLS. (L. Sammaritano, Weill-Cornell Medical College, NY)Section IV. Treatment of SLENon Steroidal agents (TBD)Steroids (TBD)Antimalarials (TBD)Cytotoxic Agents (TBD)Biological Agents (TBD)Non-Pharmacological Therapies in SLE (TBD)


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