Serpin Structure and Evolution

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems.
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Audience

Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

 

Book information

  • Published: November 2011
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-385950-1


Table of Contents

1. Development of inhibitors of PAI-1

Daniel Lawrence

2. Kinetics of Serpin interactions with cofactors and proteases

Steven Olson

3. Fluorescence Correlation Spectroscopy (FCS) or Single molecule FRET

Anne Gershenson

4. Serpin-enzyme receptors (LRP)

Dudley Strickland

5. Predicting serpin / protease interactions

Jiangning Song

6. Serpins and autophagy

David Perlmutter

7. Plant Serpins

Tom Roberts

8. High throughput Drug discovery

Bibek Gooptu

9. Use of mouse models to study maspin function

Ming Zhang

10. The study of antitrypsin deficiency using animal models

Jeffrey Teckman

11. Use of Mouse Models to study PAI-1

Paul Declerck

12. Production of serpins using cell free systems

Clifford Luke

13. Studying serpin polymerisation in vitro

James Huntington

14. Serpins and neural function

Denis Monard

15. Probing serpin conformational change using mass spectrometry and related methods

Patrick Wintrode

16. Studying Serpin conformational change

Randy Read

17. Production of serpins in bacteria

Mary Pearce

18. Inhibition of cysteine proteases by serpins

Jan Potempa

19. Post transcriptional regulation of serpins

Rob Medcalf

20. Serpins and the complement system

Rob Pike & Lakshmi Wijeyewickrema

21. Serpins in Caenorhabditis elegans

Stephen Pak & Gary Silverman

22. PEDF and angiogenesis

Patricia Becerra

23. The Serpinb1 knockout mouse

Charaf Benarafa

24. Biophysical approaches to studying serpin folding

Steve Bottomley

25. TALS for studying the proteases inhibited by Serpins

Chris Overall