Serpin Structure and Evolution book cover

Serpin Structure and Evolution

Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems.

Audience
Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists

Included in series
Methods in Enzymology

Hardbound, 552 Pages

Published: November 2011

Imprint: Academic Press

ISBN: 978-0-12-385950-1

Contents

  • 1. Development of inhibitors of PAI-1

    Daniel Lawrence

    2. Kinetics of Serpin interactions with cofactors and proteases

    Steven Olson

    3. Fluorescence Correlation Spectroscopy (FCS) or Single molecule FRET

    Anne Gershenson

    4. Serpin-enzyme receptors (LRP)

    Dudley Strickland

    5. Predicting serpin / protease interactions

    Jiangning Song

    6. Serpins and autophagy

    David Perlmutter

    7. Plant Serpins

    Tom Roberts

    8. High throughput Drug discovery

    Bibek Gooptu

    9. Use of mouse models to study maspin function

    Ming Zhang

    10. The study of antitrypsin deficiency using animal models

    Jeffrey Teckman

    11. Use of Mouse Models to study PAI-1

    Paul Declerck

    12. Production of serpins using cell free systems

    Clifford Luke

    13. Studying serpin polymerisation in vitro

    James Huntington

    14. Serpins and neural function

    Denis Monard

    15. Probing serpin conformational change using mass spectrometry and related methods

    Patrick Wintrode

    16. Studying Serpin conformational change

    Randy Read

    17. Production of serpins in bacteria

    Mary Pearce

    18. Inhibition of cysteine proteases by serpins

    Jan Potempa

    19. Post transcriptional regulation of serpins

    Rob Medcalf

    20. Serpins and the complement system

    Rob Pike & Lakshmi Wijeyewickrema

    21. Serpins in Caenorhabditis elegans

    Stephen Pak & Gary Silverman

    22. PEDF and angiogenesis

    Patricia Becerra

    23. The Serpinb1 knockout mouse

    Charaf Benarafa

    24. Biophysical approaches to studying serpin folding

    Steve Bottomley

    25. TALS for studying the proteases inhibited by Serpins

    Chris Overall

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