Seldin and Giebisch

Seldin and Giebisch's The Kidney

Physiology & Pathophysiology

A classic nephrology reference for over 25years, Seldin & Giebisch’s The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin & Giebisch’s The Kidney is your number one source for information.

Academic and medical librarians in kidney physiology, nephrology and renal medicine. This will also serve as an excellent reference for clinical nephrologists and trainees, graduate students, researchers, academic clinicians and any pharmaceutical company working on renal medications.

Hardbound, 3290 Pages

Published: December 2012

Imprint: Academic Press

ISBN: 978-0-12-381462-3


  • "Ninety-five chapters are arranged across the two volumes under four broad themes: epithelial and nonepithelial transport and regulation; structural and functional organization of the kidney; fluid and electrolyte regulation and dysregulation; and pathophysiology of renal disease."--Reference and Research Book News, August 2013

    Praise for the Previous Edition:
    "This is an excellent in-depth compilation of all aspects of renal physiology in health and disease, presented in well-balanced in chapters with high-quality figures and ample references…This book clearly represents an excellent, useful, usable, and (in view of recent rapid scientific progress) needed update of the previous edition and will have a prominent place on my bookshelf as well as those of many others in the field." - 4 Stars!-- Jens W. Goebel, MD, University of Kentucky, for Doody’s Review


  • Section 1: Epithelial and Nonepithelial Transport and Regulation

    1 Epithelial Cell Structure and Polarity

    Michael Caplan

    2 Mechanisms of Ion Transport Across Cell Membranes & Epithelia

    Luis Reuss and Guillermo Altenberg

    3 Renal Ion-Translocating AT Phases: The P-Type Family

    Eric Feraille

    4 Mechanisms of Water Transport Across Cell Membranes & Epithelia

    Luis Reuss and Guillermo Altenberg

    5 Cell Volume Control

    Florian Lang

    6 Soute Transport, Energy Consumption, and Production in the Kidney

    Hitoshi Endou and Takashi Sekine

    7 Electrophysiological Analysis of Transepithelial Transport

    Lawrence G. Palmer and Henry Sackin

    8 Ion Channels and Electro-physiological Properties of Transport

    James Stockand

    9 Exchange of Fluid and Solutes Across Microvascular Walls

    C. Charles Michel

    10 External Balance of Electrolytes and Acids and Alkali

    Man S. Oh

    11 Cilium

    Bradley Yoder

    12 Inter-cellular Junctions

    Alan S. L. Yu, Jano Peti-Perterdi, Fiona Hanner

    13 Principles of Cell Signaling

    Lloyd Cantley

    14 Scaffolding Proteins in Transport Regulation

    Paul A. Welling

    15 The Renin-Angiotensin System

    Thomas M. Coffman

    16 Neural Control of Renal Function

    Ulla C. Kopp and EJ Johns

    17 Eicosanoids and the Kidney

    Matthew Breyer, Raymond C. Harris, Richard M. Breyer

    18 Extracellular Nucleotides and Renal Function

    Robert J. Unwin and David Shirley

    19 Paracrine Regulation of Renal Function by Dopamine

    Pedro Jose

    Section 2: Structural and Functional Organization of the Kidney

    20 Structural Organization of the Mammalian Kidney

    Wilhelm Kriz and Brigitte Kaissling

    21 Biophysical Basis of Glomerular Filtration

    Roland C. Blantz and Scott Thomson

    22 Glomerular Structure and Cell Biology

    Susan Quaggin

    23 Function of the Juxtaglomerular Apparatus

    Jurgen Schnermann and Hayo Castrop

    24 Renal Cortical & Medullary Microcirculations

    Thomas L. Pallone

    25 Molecular and Cellular Mechanisms of Kidney Development

    Sanjay K. Nigam and Kevin T. Bush

    26 Molecular and Cellular Mechanisms of Glomerular Capilary Development

    Jeffrey H. Miner and Dale R. Abrahamson

    27 Postnatal Renal Development

    Michael Baum

    28 Renal Hyperplasia and Hypertrophy

    Stuart J. Shankland

    29 Stem Cells

    Qais Al-Awqati and Juan Oliver

    Section 3: Fluid and Electrolyte Regulation and Dysregulation

    30 Epithelial Na+ Channels

    Thomas R. Kleyman

    31 Anion Channels

    William B. Guggino

    32 NaCL Co-transporters

    Gerardo Gamba

    33 Sodium and Chlorid Transport

    Alan M. Weinstein

    34 Sodium Chloride Transport in the Loop of Henle, Distal Convoluted Tubule, and Collecting Duct Gerardo Gamba and Laurent Schild

    35 Mineralocorticoid Action in the Aldosterone-Sensitive Distal Nephron

    Johannes Loffing and Oliver Staub

    36 Inherited Disorders of Renal Salt Homeostasis: Insights From Molecular Genetics Studies

    Rick Lifton

    37 Natriuretic Hormones

    David L. Vesely

    38 Physiology & Pathophysiology of Sodium Retention and Wastage

    Biff F. Palmer, Donald W. Seldin and Robert J. Alpern

    39 Physiology of Hypertension

    John E. Hall

    40 Physiology & Pathophysiology of Diuretic Action

    David H. Ellison

    41 Aquaporin Water Channels in Mammalian Kidney

    Soren Nielsen

    42 Thirst and Vasopressin

    Gary L. Robertson

    43 The Urine Concentrating Mechanism and Urea Transporters

    Jeff M. Sands and Harold Layton

    44 Hyponatremia

    Richard H. Sterns

    45 Hypernatremic States

    Laurence Chan and Chris Rivard

    46 Polyuria and Diabetes Insipidus

    Daniel G. Bichet

    47 The Molecular Biology of Renal Potassium Channels

    Wenhui Wang and Chou Long Huang

    48 Extrarenal Potassium Metabolism

    Robert M. Rosa

    49 Regulation of Potassium Excretion

    Gerhard Giebisch and Lisa Satlin

    50 Potassium Deficiency

    Giovambattista Capasso, Miriam Zacchia and Francesco Trepiccione

    51 Clinical Disorders of Hyperkalemia

    Mitchell Halperin and Kamel

    52 Control of Intracellular pH

    Walter F. Boron and Mark Bevensee

    53 Sodium-Coupled Bicarbonate Transporters

    Ira Kurtz

    54 The SLC4 Anion Exchanger Gene Family

    Seth Alper

    55 Cellular Mechanisms of Renal Tubular Acidification

    Patricia Preisig, L. Lee Hamm and Robert Alpern

    56 Chemoreceptors, Breathing, and pH

    Eugene Nattie

    57 Renal Ammonium Ion Production and Excretion

    Norman P. Curthoys

    58 Clinical Syndromes of Metabolic Alkalosis

    Orson Moe, Robert J. Alpern and Donald W. Seldin

    59 Clinical Syndromes of Metabolic Acidosis

    Reto Krapf, Donald W. Seldin and Robert J. Alpern

    60 Respiratory Alkalosis and Acidosis

    Horacio J Adrogue and Nicolaos Madias

    61 Mechanisms and Disorders of Magnesium Metabolism

    Karl P. Schlingmann and Martin Konrad

    62 Calcium Channels

    René J.M. Bindels and Joost Hoenderop

    63 The Calcium-Sensing Receptor

    Edward Brown

    64 Renal Calcium Metabolism

    Peter A. Friedman and Jose Bernardo

    65 The Hormonal Regulation of Calcium Metabolism

    Rajiv Kumar

    66 Disorders of Calcium Metabolism

    John Wysolmerski and Cristina Dumitru

    67 Pathogenesis and Treatment of Nephrolithiasis

    Fredric L. Coe, Elaine Worcester and Andrew Evan

    68 Proximal Tubular Handling of Phosphate

    Heini Murer, Jurg Biber, Nati Hernando, and Ian Forster

    69 Clinical Disturbances of Phosphate Homeostasis

    Rajiv Kumar

    70 Glucose Reabsorption in the Kidney

    Ernest M. Wright

    71 Amino Acids, Oligopeptides, and Hyperaminoacidurias

    Francois Verrey, Simone R. Camargo, Victoria Makrides, Robert Kleta

    72 Organic Anion and Cation Transporters in Renal Elimination of Drugs

    Gerhard Burckhardt and Herman Koepsell

    73 Renal Filtration, Transport, and Metabolism of Albumin and Albuminuria

    Erik I. Christensen, Rikke Nielsen, Henrik Birn

    Section 4: Pathophysiology of Renal Disease

    74 Physiologic Principles in the Clinical Evaluation of Electrolyte, Water, and Acid-Base Disorders Daniel Batlle

    75 Biomarkers of Assessment of Renal Function (AKI/CKD)

    Prasad Devarajan

    76 Pathophysiology of Acute Kidney Injury

    Bruce A Molitoris and Asif Sharfuddin

    77 Ischemic Renal Disease

    William L. Henrich, Lance Dworkin, and Christopher Cooper

    78 Pathophysiology and Pathogenesis of Diabetic Nephropathy

    Fuad N. Ziyadeh

    79 Renal Failure in Cirrhosis

    Robert W. Schrier and Pere Gines

    80 Autosomal Dominant Polycystic Kidney Disease and Inherited Cystic Diseases

    Stefan Somlo

    81 Renal Physiology and Disease in Pregnancy

    Ananth Karunmanchi

    82 Immune-Mediated and Other Glomerular Diseases

    John R. Sedor and Mike Madaio

    83 Immunologic Mechanisms of Vasculitis

    J. Charles Jennette, Jonathan Homeister, Ronald J. Falk

    84 Genetic Abnormalities in Glomerular Function

    Clifford E Kashtan and Yoav Segal

    85 Cellular Mechanisms of Drug Nephrotoxicity

    Zoltán Huba Endre and Robert Walker

    86 Role of Glomerular Pressure in Progression

    Roberto Zatz

    87 Role of Protinuria in Progression

    Giuseppe Remuzzi

    88 The Inflammatory Response to Ischemic Acute Renal Injury

    Christopher Y. Lu

    89 Oxidants in Progressive Kidney Disease

    Sudhir Vithalbhai Shah

    90 Chronic Kidney Disease

    William E. Mitch

    91 Mineral Metabolism and Bone

    L. Darryl Quarles

    92 Hematopoiesis and the Kidney

    Armin Kurtz

    93 Electrolyte Disturbances in Dialysis

    Biff Palmer

    94 Homeostasis of Solute and Water by the Transplanted Kidney

    J. Harold Helderman

    95 Disposition and Dose Requirements of Drugs in renal Insufficiency

    D. Craig Brater, Kathleen Giacomini, Claire Weiss, Par Matsson


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