Research Methods in BIomineralization Science book cover

Research Methods in BIomineralization Science

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.


Biochemists, biophysicists, molecular biologists, analytical chemists, and physiologists.

Included in series
Methods in Enzymology

Hardbound, 704 Pages

Published: November 2013

Imprint: Academic Press

ISBN: 978-0-12-416617-2


  • Determining solution chemistry, structure and nucleation
    1. Development of accurate force fields for the simulation of biomineralisation
      Paolo Raiteri, Raffaella Demichelis and Julian D. Gale
    2. The integration of ion potentiometric measurements with chemical, structural and morphological analysis to follow mineralization reactions in solution.
      Wouter Habraken
    3. Investigating the Early Stages of Mineral Precipitation by Potentiometric Titration and Analytical Ultracentrifugation
      Matthias Kellermeier, Helmut Cölfen, Denis Gebauer
    4. Replica Exchange Methods in Biomineral Simulations
      Adam Wallace
    5. SAXS in inorganic and bio-inspired research
      Tomasz M. Stawski and Liane G. Benning
    6. In situ Solution Study of Calcium Phosphate Crystallization Kinetics
      Haihua Pan, Shuqin Jiang, Tianlan Zhang and Ruikang Tang

    Probing structure and dynamics at surfaces and interfaces
    7. Design, fabrication, and applications of in situ fluid cell TEM to mineralization reactions
      Dongsheng Li, Michael H. Nielsen and James J. De Yoreo
    8. X-ray Absorption Spectroscopy for the Structural Investigation of Self-Assembled-Monolayer-Directed Mineralization
      Jonathan R. I. Lee, Michael Bagge-Hansen, Trevor M. Willey, Robert W. Meulenberg, Michael H. Nielsen, Ich C. Tran and Tony van Buuren
    9. Cryo-TEM Analysis of Collagen Fibrillar Stucture
      Bryan D. Quan and Eli D. Sone

    Biomimetic crystallization techniques in vitro and in silico
    10. Preparation of organothiol self-assembled monolayers for use in templated crystallization
      Michael H. Nielsen and Jonathan R.I. Lee
    11. Experimental techniques for the growth and characterization of silica biomorphs and silica gardens
      Matthias Kellermeier, Fabian Glaab, Emilio Melero-García and Juan Manuel García-Ruiz
    12. Precipitation in liposomes as a model for intracellular biomineralization
      Derk Joester
    13. Polymer Mediated Growth of Crystals and Mesocrystals
      Helmut Coelfen
    14. Phage display for the discovery of hydroxyapatite associated peptides
      Hyo-Eon Jin, Woo-Jae Chung and Seung-Wuk Lee

    Protein structure, interactions and function
    15. Quantitatively and Kinetically Identifying Binding Motifs of Amelogenin Proteins to Mineral Crystals through Biochemical and Spectroscopic Assays
      Li Zhu, Peter Hwang, H. Ewa Witkowska, Haichuan Liu and Wu Li
    16. Using the RosettaSurface Algorithm to Predict Protein Structure at Mineral Surfaces
      Michael S. Pacella, Da Chen Emily Koo, Robin A. Thottungal and Jeffrey J. Gray
    17. Investigating Protein Function in Biomineralized Tissues using Molecular Biology Techniques
      Christopher E. Killian and Fred H. Wilt

    Mapping biomineral morphology and ultrastructure
    18. Imaging the nanostructure of bone and dentin through small- and wide-angle scattering
      Silvia Pabisch, Wolfgang Wagermaier, Thomas Zander, Chenghao Li and Peter Fratzl
    19. Synchrotron X-ray Nanomechanical Imaging of Mineralized Fibre Composites
      A. Karunaratne, N.J. Terrill and H. S. Gupta

    Mapping mineral chemistry
    20. Application of Total X-ray Scattering Methods and Pair Distribution Function Analysis for Study of Structure of Biominerals
      Richard J. Reeder and F. Marc Michel
    21. X-ray Microdiffraction of Biominerals
      Nobumichi Tamura and P.U.P.A Gilbert
    22. FT-IR and Raman studies of structure and bonding in mineral and organic-mineral composites
      Jinhui Tao
    23. A mixed flow reactor method to synthesize amorphous calcium carbonate under controlled chemical conditions
      Christina R. Blue, J. Donald Rimstidt and Patricia M. Dove


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