Regenerative Medicine Applications in Organ Transplantation

Edited by

  • Giuseppe Orlando, Marie Curie Fellow Assistant Professor of Surgery Department of General Surgery, Section of Transplantation Wake Forest Baptist Health Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA

Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine.

Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.

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Audience

Basic and clinical researchers in the fields of regenerative medicine, transplantation, tissue engineering, biomaterial sciences, stem cell biology, developmental biology, and related fields

 

Book information

  • Published: November 2013
  • Imprint: ACADEMIC PRESS
  • ISBN: 978-0-12-398523-1

Reviews

"…represents an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive, up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation,November 27,2014

"…an invaluable reference for students, physicians, and researchers who are interested in getting a comprehensive up-to-date snapshot on how regenerative medicine and organ transplantation are reshaping the medical profession."--Transplantation, Nov 27 2014

"Given the implications that a chronic shortage of organs has on public health and society, this book is a valuable resource for students and professionals seeking to do something about this problem by taking advantage of cutting-edge developments in one of those most dynamic scientific disciplines existing today, namely regenerative medicine."--Regenerative Medicine 2014 9(3)
"The text is well organized…Chapters on tracheal reconstruction and bladder reconstruction are impressive in demonstrating proximity to clinical utility and indicate that simple structural elements can be manufactured and implanted in humans to bridge a limited defect…if you want to spark your enthusiasm for what is to come, then this textbook is a fine first step into the future."--American Journal of Transplantation, June 2014
"With beautiful illustrations throughout that greatly enhance the overall reading experience of this book, this book is a must-have for anyone interested in tissue engineering and organ transplantation. This is one of the best textbooks I have come across that combines surgery with science, and it is a must for all surgeon-scientists involved in tissue engineering and organ transplantation."--BCS Online, April 3, 2014
"This book succeeds in providing a detailed and comprehensible description of current and future therapies for solid organ replacement. It is unique in that it encompasses all solid organs and compiles a great deal of research. It will serve as a valuable reference for all those involved in the evolution of transplantation." Rating: 4 Stars--Organ Transplantation review on Doody.com, January 24, 2014




Table of Contents

Meet the Editors
  Giuseppe Orlando
Preface
  Roy Calne
1. Introduction: Regenerative medicine and solid organ transplantation from a historical perspective
  Joseph P. Vacanti, Jean Bernard Otte and Jason A. Wertheim
2. Solid organ transplantation: has the promise been kept and the needs met?
  James Neuberger and Marco Carbone

Principles of Regenerative Medicine and Cell, Tissue, and Organ Bioengineering
3. Strategies for the specification of tissue engineering biomaterials
  David F. Williams
4. Principles of Stem Cell Biology
  Paolo DeCoppi
5. Principles of cell sheet technology
  Teruo Okano
6. Principles of bioprinting technology
  Tao Xu
7. Synthetic biomaterial for regenerative medicine applications
  Mark Van Dyke and Aaron Goldstein
8. Natural biomaterials for regenerative medicine applications
  S Badylak and Stephen F. Badylak
9. Bioartificial biomaterials for regenerative medicine applications
  Gianluca Ciardelli and Valeria Chiono
10. Bioactivated materials for cell and tissue guidance
  Paolo Antonio Netti Sr.
11. Biocompatibility and immune response to biomaterials
  B Brown, S Badylak and Stephen F. Badylak
12. Harnessing regenerative and immunomodulatory properties of stem cells
  Peiman Hematti
13. Bioreactors for tissue engineering purposes
  David A. Vorp and Justin Sol Weinbaum

Kidney
14. Current status of renal transplantation
  Jeffrey Rogers
15. Living related renal transplantation: progress, pitfalls and promise
  Nizam Mamode
16. Machine perfusion of kidneys donated after cardiac death: the Carrel and Lindbergh legacy
  Jacques Pirenne, Ina Jochmans and Ina Jochmans
17. Renal regeneration: the bioengineering approach
  Giuseppe Orlando
18. Renal regeneration: the stem cell biology approach
  Laura Perin
19. Renal regeneration: the developmental approach
  S Nigam

Liver
20. Current status of liver transplantation
  Jan Lerut
21. Living related liver transplantation: progress, pitfalls and promise
  Jan Lerut
22. Donation after cardiac death liver transplantation
  Paolo Muiesan
23. Artificial liver support
  Xavier Wittebole and Pierre-Francois Laterre
24. Liver regeneration: the bioengineering approach
  Basak E. Uygun and K Uygun
25. Liver regeneration: the developmental biology approach
  D A. Rudnick
26. Liver regeneration: the stem cell approach
  Gianfranco Alpini and Shannon Glaser
27. Liver bioengineering using human cells
  Shay Soker

Heart
28. Current status of heart transplantation
  Mandeep Mehra and Sunu Thomas
29. Artificial heart support
  Oliver Van Caenegem and Luc Marie Jacquet
30. Heart regeneration: the bioengineering approach
  Dror Seliktar
31. Heart regeneration: the developmental and stem cell biology approach
  Timothy Nelson

Small Bowel
32. Current status of intestinal transplantation
  Gennaro Selvaggi and Andreas Tzakis
33. Living related small bowel transplantation: progress, pitfalls and promise
  Ivo G. Tzvetanov, Lorena Bejarano-Pineda and Enrico Benedetti
34. Intestinal regeneration: the bioengineering approach
  Khalil N. Bitar
35. Intestinal regeneration: the developmental biology approach
  Jose E. Garcia-Arraras
36. Intestinal regeneration: stem cell approach
  T C. Grikscheit
37. Building blocks for engineering the small intestine
  M Wong

Endocrine pancreas and islets of Langerhans
38. Current status of pancreas transplantation
  George W. Burke III, Gaetano Ciancio and M Chavez
39. Living related pancreas transplantation: progress, pitfalls and promise
  Rainer W. Gruessner
40. Current status of islet transplantation
  Giuseppe Remuzzi
41. Pancreatic islets regeneration: the bioengineering approach
  Giuseppe Orlando and Shay Soker
42. Pancreatic islet regeneration: the developmental and stem cell biology approach
  Juan Dominguez-Bendala, Camillo Ricordi, Giacomo Lanzoni and Luca Inverardi
43. Microencapsulation technology
  E C. Opara
44. Autologous islets transplantation
  Alan C. Farney

Lung
45. Current status of lung transplantation
  Dirk Emiel Van Raemdonck and Toni Lerut
46. Living related lung transplantation: progress, pitfalls and promise
  Hiroshi Date, T Horacic and S Seiko
47. Artificial Lung Support
  Shaf Keshavjee
48. Lung regeneration: the bioengineering approach
  Joan E. Nichols
49. Lung regeneration: the developmental biology approach
  S Janes
50. Lung regeneration: stem cell approach
  Shigeo Masuda

Composite tissues allotransplantation
51. Current status of CTA
  Jean-Michel Dubernard and Palmina Petruzzo
52. The Neourinary Conduit
  Anthony Atala
53. Upper airways bioengineering
  Paolo Macchiarini
54. Skin regeneration and bioengineering
  Dennis P. Orgill and Ryan Gobble
55. The Use of Skin Substitutes in the Treatment of Burns
  Alexander Marcus Seifalian
56. Bone regeneration and bioengineering
  Ranieri Cancedda
57. Nerve regeneration and bioengineering
  Tina Sedaghati and Alexander Marcus Seifalian
58. Vessel bioengineering
  Toshiharu Shinoka and Christopher Kane Breuer
59. Corneal bioengineering
  Michele De Luca and Graziella Pellegrini
60. Esophagus bioengineering
  Paolo DeCoppi

Immunosuppression-free transplantation in the regenerative medicine era
61. Stem cell-based approach to immunomodulation
  Kathryn Wood
62. Immunosuppression-free renal transplantation
  Fred Faendrich
63. Immunosuppression-free liver transplantation
  Tommaso Maria Manzia, Giuseppe Tisone and Leonardo Baiocchi
64. Biomarkers of tolerance in liver transplantation
  Takaaki Koshiba
65. Biomarkers of tolerance in renal transplantation
  Jean-Paul Soulillou, Sophie Brouard and Faouzi Braza
66. Immunocloacking
  Lauren Brasile
67. The need for immune modulation despite regenerative medicine
  Lucienne Chatenoud
68. Stem cells approach to I/R injury
  Eiji Kobayashi and Takumi Teratani
69. Xenotransplantation: past, present and future
  Pierre Gianello
70. Regenerative medicine as an industry
  Paolo Antonio Netti Sr. and Alessandro Sannino
71. Ethics in regenerative medicine and transplantation
  Nancy M P King
Epilogue: Organ Bioengineering and Regeneration as the new Holy Grail of Organ Transplantation
  Giuseppe Orlando