Regenerative Biology and Medicine book cover

Regenerative Biology and Medicine

Regenerative Biology and Medicine, Second Edition - Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine - discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering.

Audience
Researchers and students in biology, chemistry, and bioengineering; medical students; academic and clinical physicians; and research investigators

Paperback, 474 Pages

Published: May 2012

Imprint: Academic Press

ISBN: 978-0-12-384860-4

Reviews

  • "...a terrific reference for anyone toying with the idea of moving into this field. The text offers an enormous breath of coverage of different systems currently under investigation, and Stocum provides a central theme that pits regenerative ability against fibrosis as a way to conceptually untangle the limited regenerative capacity of humans...Stocum has erected an umbrella large enough for scientists of diverse backgrounds to initiate conceptual cross-talk between those actively involved in the biology of regeneration and those targeting its clinical application." - Ken Muneoka, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana “…of tremendous importance to researchers and clinicians working in the fields of regeneration and stem cell biology.” - Jonathan Henry, University of Illinois at Urbana-Champaign “This text integrates information from cell and developmental biology with regenerative biology, tissue engineering and clinical practice. The breadth and detail of this intellectual landscape are derived from the author’s long commitment to the problems of regeneration, and help to make this volume a landmark publication for regenerative medicine.” - Jeremy Brockes, University College London “This book is a superb in-depth analysis of the existing potential of the tissues of the body to replace cells and tissues and how to promote this ability for the sake of repair….Every institute should have it as their background reading and mission statement. I can't recommend it highly enough, it has been long awaited.” - Malcolm Maden, King’s College London “…wonderful and comprehensive, providing readers with the basis of regeneration biology and medicine. The author emphasizes the necessity of understanding the biology of regeneration for a true appreciation of its practice in clinical medicine.” - Katsutoshi Yoshizato, University of Hiroshima

Contents


  • Preface

    Part I Regenerative Biology

    1. An Overview of Regenerative Biology

    I. Introduction

    II. A Brief History of Regenerative Biology

    III. Regeneration Occurs at All Levels of Biological Organization

    IV. Mechanisms of Vertebrate Regeneration

    V. The Niche Concept in Tissue Repair

    VI. Approaches to the Study of Regeneration

    Summary

    References

    2. Repair of Skin by Fibrosis

    I. Introduction

    II. Structure of Adult Mammalian Skin

    III. Phases of Repair By Fibrosis

    IV. Tattoos and Fetal Skin Have a Minimal Immune Response to Wounding

    V. Comparative Molecular Analysis of Wound Repair

    Summary

    References

    3. Regeneration of Epidermal Structures

    I. Introduction

    II. Maintenance Regeneration of Interfollicular Epidermis and Hair

    III. Regeneration of Nails

    IV. Regeneration of Cornea

    V. Regeneration of the Lens

    VI. Regeneration of Avian and Mammalian Auditory Sensory Cells

    Summary

    References

    4. Regeneration of Neural Tissues

    I. Introduction

    II. Structure of the Nervous System

    III. Regeneration of Axons

    IV. Neurogenesis in the Adult CNS

    Summary

    References

    5. Regeneration of Digestive, Respiratory and Urinary Tissues

    I. Introduction

    II. Regeneration of the Intestinal Epithelium

    III. Regeneration of the Liver

    IV. Regeneration of the Pancreas

    V. Regeneration of Respiratory Epithelium

    VI. Regeneration of Kidney Tubule Epithelium

    Summary

    References

    6. Regeneration of Musculoskeletal Tissues

    I. Introduction

    II. Regeneration of Skeletal Muscle

    III. Regeneration of Bone

    IV. Regeneration of Articular Cartilage, Meniscus, Tendon and Ligament

    V. Regeneration of Dental Tissues

    Summary

    References

    7. Regeneration of Cardiac Muscle and Hematopoietic Tissues

    I. Introduction

    II. Regeneration of Cardiac Muscle

    III. Regeneration of Hematopoietic Cells

    Summary

    References

    8. Regeneration of Appendages

    I. Introduction

    II. Urodele Limb Regeneration

    III. What Inhibits Limb Regeneration in Adult Frogs, Birds and Mammals?

    IV. Regeneration of Mammalian Appendages

    V. Stimulation of Regeneration in Anuran and Mammalian Appendages

    VI. Comparative Analysis as a Tool to Understand Limb Regeneration

    Summary

    References

    Part II Regenerative Medicine

    9. Strategies of Regenerative Medicine

    I. Introduction

    II. Biomimetic Devices and Organ Transplant

    III. Cell Transplants

    IV. Bioartificial Tissue Construction

    V. Chemical Induction of Regeneration in situ

    Summary

    References

    10. Regenerative Medicine of Epidermal Structures

    I. Introduction

    II. Repair of Skin Wounds and Burns

    III. Stimulation of Hair Regeneration

    IV. Limbal Cell Transplants to Regenerate the Cornea

    Summary

    References

    11. Regenerative Medicine of Neural Tissues

    I. Introduction

    II. Therapies for Regeneration of Peripheral Nerves

    III. Therapies for Trauma to the Mammalian Central Nervous System

    IV. Therapies for Neurodegenerative Diseases

    Summary

    References

    12. Regenerative Therapies for Digestive, Respiratory and Urinary Tissues

    I. Introduction

    II. Regenerative Therapies for the Liver

    III. Regenerative Therapies for the Pancreas

    IV. Regenerative Therapies for the Esophagus and Intestine

    V. Regenerative Therapies for the Respiratory System

    VI. Regenerative Therapies for the Urinary System

    Summary

    References

    13. Regenerative Therapies for Musculoskeletal Tissues

    I. Introduction

    II. Therapies for Skeletal Muscle

    III. Regenerative Therapies for Articular Cartilage

    IV. Regenerative Therapies for Meniscus

    V. Regenerative Therapies for Non-Union Fractures and Critical Size Gaps in Bone

    VI. Regenerative Therapies for Teeth and Periodontium

    VII. Regenerative Therapies for Tendon and Ligament

    Summary

    References

    14. Regenerative Therapies for Hematopoietic and Cardiovascular Tissues

    I. Introduction

    II. Therapies for Hematopoietic Disorders

    III. Therapies for Damaged Blood Vessels

    IV. Therapies for Infarcted Myocardium

    Summary

    References

    Part III Perspective

    15. Retrospect and Prospect

    I. Introduction

    II. Achievements and Challenges

    III. Bioethics in Regenerative Medicine

    IV. Exciting Future Prospects for Regenerative Biology and Medicine

    V. Concluding Remarks

    References

    Index








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