Pyridines: from lab to production

Edited by

  • Eric F.V. Scriven, University of Florida, Gainesville, FL, USA

Provides a synthetic armory of tools to aid the practicing chemist by reviewing the most reliable historical methods alongside new methods/ Written by scientists who have actually used these in synthesis. By emphasizing tricks and tips to optimize reactions for the best yields and purity, which are often missing from the primary literature, this book provides another dimension for the synthetic chemist. A combined academic and industrial approach evaluates the best methods for different scales of reaction and discusses practical tips (e.g. when to stop a reaction early to maximize purity or when to re-use side products). Chapters also assess whether to make or source starting materials, how to connect them and what are the best synthetic routes. The book is designed to be a stand-alone reference, but also provides cross references to leading reviews and the Comprehensive Heterocyclic Chemistry reference works for those who want to learn more.
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A reference book for organic and pharmaceutical chemists and for those interested in the synthesis and manufacture of pyridine and its derivatives including those working in the polymer and material sciences. It is also appropriate as a reference book for the practical classes on synthetic organic chemistry.


Book information

  • Published: January 2013
  • ISBN: 978-0-12-385235-9


"Editor Scriven…presents this comprehensive reference for academics and industrialists working in the synthesis of pyridine derivatives. Strategic considerations for economizing reagents are discussed in the introduction; in particular, the question of whether to install substituents before or after cyclization is highlighted."--Reference & Research Book News, October 2013

Table of Contents

1. Introduction 
2. Ring synthesis
3. Attachment at ring positions
4. Substituent modifications and cyclizations  
5. Formation of completely or partially reduced pyridines and quinolines  
6. Applications to alkaloid synthesis
7. Fluoropyridines 
8. Pyridine reagents 
9. Application of Flow Reactors in Pyridine Synthesis